Description of Research Expertise
Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.
Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination
Techniques: multiphoton imaging
Selected Publications
Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurol. 2024 Feb;271(2):733-747. doi: 10.1007/s00415-023-12058-6. Epub 2023 Oct 27. PMID: 37891417. : 2024.
Hannah Loo and Jennifer L Orthmann-Murphy: How do deep cortical microglia impair remyelination? Gordon Research Conference Poster - Glial Biology : 2023.
Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani: Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource Molecular Genetics and Metabolism : 2023.
Joseph Gallegos, Hannah Loo, Thomas Malloy, Jennifer L Orthmann-Murphy: Does a toxic reactive astrocyte subtype influence oligodendrocyte recovery in the cortex? ACTRIMS Annual Meeting Poster 434 : 2023.
Al-alya Alsabah, Zehra Isik Hasiloglu, Rami Massie, Bernard Brais, *Jennifer Orthmann Murphy, *Roberta La Piana: Prevalence of Peripheral Nervous System Involvement in Adult Leukodystrophies AAN annual meeting : 2023.
Alexandra Kornbluh and Jennifer L Orthmann-Murphy: A Practical Approach to Longitudinal Neurological Care of Adults With X-linked Adrenoleukodystrophy and Adrenomyeloneuropathy (X-ALD/AMN) American Academy of Neurology Annual Meeting Poster P17-4.009 : 2022.
Papapetropoulos S, Pontius A, Finger E, Karrenbauer V, Lynch DS, Brennan M, Zappia1 S, Koehler W, Schoels L, Hayer SN, Konno T, Ikeuchi T, Lund T, Orthmann-Murphy J, Eichler E and Wszolek ZK: Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development Frontiers in Neurology : https://doi.org/10.3389/fneur.2021.788168,2022.
Bloom MS, Orthmann-Murphy J. Grinspan JB: Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination
ASN Neuro
14 : doi: 10.1177/17590914221097510,2022.
E Bae, R Shinohara, J Orthmann-Murphy: BOSS: Beta-mixture Unsupervised Oligodendrocytes Segmentation System bioRxiv : 2022.
Ahmad Almutlaq and Jennifer L Orthmann-Murphy: Adult Polyglucosan Body Disease: An Adult-Onset Leukodystrophy That Could Be Mistaken For Multiple Sclerosis MULTIPLE SCLEROSIS JOURNAL - ACTRIMS Annual Meeting Poster : 2022.
Academic Contact Information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia,
PA
19104
Phone: 215-662-3606
Patient appointments: 800-789-7366