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Jeffrey S. Arkles, MD

Jeffrey S. Arkles, MD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Arkles is employed by Penn Medicine.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2013
  • Clinical Cardiac Electrophysiology, 2014
  • Internal Medicine, 2010

Clinical Expertise:

  • Ablation of Idiopathic Ventricular Tachycardia
  • Advanced Cardiac EP Imaging
  • Arrhythmia
  • Atrial Fibrillation Ablation
  • Atrial Fibrillation Treatment
  • Cardiac Catheter Ablation
  • Cardiac Resynchronization Therapy (CRT)
  • Complex Arrhythmia
  • Electrocardiogram (EKG or ECG)
  • Electrophysiology (EP) Testing
  • Epicardial Ablation
  • Heart Block
  • Heart Palpitations
  • Heart Rhythms - Slow/Fast
  • Holistic Medicine
  • Hypertrophic Obstructive Cardiomyopathy
  • Implantable Cardiac Devices
  • Inherited Arrhythmia Diseases
  • Intracardiac Echocardiography (ICE)
  • Laser Lead Extraction
  • Minority Populations
  • Sinus Node Dysfunction (SND)
  • Subcutaneous Implantable Cardioverter-Defibrillator (S-ICD)
  • Supraventricular Tachycardia (SVT)
  • Syncope (Fainting)
  • Ventricular Tachycardia
  • Ventricular Tachycardia Ablation
  • Wolff-Parkinson-White Syndrome

Description of Clinical Expertise

Clinical cardiac electrophysiology

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Jefferson Medical College
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American College of Cardiology, National Heart Rhythm Society, National

Hospital Affiliation

Dr. Arkles is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Translation methods in cardiology.

Selected Publications:

Rodell CB, Lee ME, Wang H, Takebayashi S, Takayama T, Kawamura T, Arkles JS, Dusaj NN, Dorsey SM, Witschey WR, Pilla JJ, Gorman JH 3rd, Wenk JF, Burdick JA, Gorman RC, PMID: 27729419: Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to Infarcted Myocardium to Limit Left Ventricular Remodeling. Circ Cardiovasc Interv 9 (10): 1-12,2016.

Seki M, LaCanna R, Powers JC, Vrakas C, Liu F, Berretta R, Chacko G, Holten J, Jadiya P, Wang T, Arkles JS, Copper JM, Houser SR, Huang J, Patel VV, Recchia FA: Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation. J Pharmacol Exp Ther 358 (3): 441-9,2016.

Arkles J, Cooper J: The Emerging Roles of Leadless Devices. Curr Treat Options Cardiovasc Med 18 (2): 14,2016.

Arkles, J.S., Callans, D.J: How to Strategize the “Redo” Ablation Procedure. Practical Guide to Catheter Ablation of Atrial Fibrillation, 2nd edition. (Chapter 25): 343-350,2016.

Peters A, Al Maluli H, Nayeemuddin M, Mirza A, Modi D, Arkles J, Bashir R: Thrombotic thrombocytopenia purpura: a potentially reversible cause of complete heart block. Am J Med 128 (10): e1-3,2015.

Han QJ, Witschey WR, Fang-Yen CM, Arkles JS, Barker AJ, Forfia PR, Han Y: Altered Right Ventricular Kinetic Energy Work Density and Viscous Energy Dissipation in Patients with Pulmonary Arterial Hypertension: A Pilot Study Using 4D Flow MRI. PLoS One 10 (9): e0138365,2015.

Arkles J, Zado E, Supple G, Frankel DS, Callans D, Marchlinski F, Dixit S: Feasibility of Transseptal Access in Patients With Previously Scarred or Repaired Interatrial Septum. J Cardiovasc Electrophysiol 26 (9): 963–968,2015.

Maeda S, Chik WW, Han Y, Liang JJ, Squara F, Arkles JS, Sadek MM, Santangeli P, Frankel DS, Zado ES, Takebayashi S, Dixit S, Callans DJ, Marchlinski FE, Lin D: Effects of Age-Related Aortic Root Anatomic Changes on Left Ventricular Outflow Tract Pace-Mapping Morphologies: A Cardiac Magnetic Resonance Imaging Validation Study. J Cardiovasc Electrophysiol 26 (9): 994–999,2015.

Pierce, M, Bove F, Arkles, J: Race Specific Differences in Atrial Arrhythmias. Scientific Session ACC San Diego, CA : 2015.

Arkles, J, Marchlinski, F, Frankel, D, Supple G, Dixit, S: Feasibility of Transseptal Access in Scarred Interatrial Septae. Heart Rythym Scientific Session. San Francisco, CA : 2014.

Academic Contact Info

Hospital of the University of Pennsylvania
Cardiovascular Medicine Division
9 Founders Pavilion
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-6392
Patient appointments: 800-789-7366 (PENN)