Description of Research Expertise
Jay Dorsey, MD, PhD has been continuously funded by the NIH for the past decade. He has expertise in genomics, precision medicine, circulating tumor material/liquid biopsy, molecular diagnostics, cancer biomarkers, nanoparticle therapeutics, preclinical tumor models, and clinical trials. His lab focuses on translational-facing research that explores areas of brain tumor biology, biomarkers of resistance/sensitivity to radiation and chemotherapies and identification of predictive/prognostic single-cell biomarkers of solid tumors, including GBM, lung and melanoma. He is Co-Leader of the Abramson Cancer Center's RadOnc Translational Center of Excellence.
Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of the DEI-focused (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.
He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.
His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.
Selected Publications
Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in
cancer stem cells: Biological and therapeutic implications Pharmacol Ther. : 2022.
Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Int J Radiat Oncol Biol Phys. 110 (5): 1451-1465,2021.
Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel ACS Biomater Sci Eng. : 2021.
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh, SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6
and CD40 Nat Commun. 12 (1): 2021.
Jean-Baptiste SR, Feigenberg SJ, Dorsey JF, Kao GD: Personal and Prognostic: Tissue and Liquid Biomarkers of Radiotherapeutic Response in Non-Small Cell Lung Cancer Semin Radiat Oncol. 31 (2): 149-154,2021.
Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK.: Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. J Neurooncol. 2020 Sep 10. doi: 10.1007/s11060-020-03618-1. Online ahead of print. PMID: 32914293
: 2020.
Frick MA, Feigenberg SJ, Jean-Baptiste SR, Aguarin LA, Mendes A, Chinniah C, Swisher-McClure S, Berman A, Levin W, Cengel KA, Hahn SM, Dorsey JF, Simone CB 2nd, Kao GD.: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clin Cancer Res. 2020 May 15;26(10):2372-2380. doi: 10.1158/1078-0432.CCR-19-2158. Epub 2020 Jan 22.
PMID: 31969332 : 2020.
Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26.
PMID: 31883794 : 2020.
Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK.: Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas. Mol Imaging Biol. 2020 Oct;22(5):1266-1279. doi: 10.1007/s11307-020-01504-w.
PMID: 32514886 : 2020.
Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M: A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment J Surg Oncol. : 2019.
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Academic Contact Information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia,
PA
19104
Phone: 215-662-2428
Patient appointments: 800-789-7366