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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
RESEARCH INTERESTS:As a Physician-Scientist, I conduct brain tumor research and specialize in treatment of patients with intracranial malignancies. I have scientific expertise in the areas of signal transduction, molecular therapeutics, brain tumor biology, and radiation biology. As a translational researcher, I am actively involved in basic mechanistic studies, the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer, and early phase clinical trials in intracranial malignancies. In a broad sense, my research focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One research focus concerns the elucidation of mechanism(s) whereby the Integrated Stress Response (ISR) modulates death receptor expression, and leveraging this understanding therapeutically. A second area of focus is the identification and characterization of circulating tumor cells (CTCs) in the peripheral blood of cancer patients including those with primary brain tumors to gain prognostic and predictive information. Finally, my laboratory has an ongoing project focused on the application and preclinical testing of novel theranostic gold nanoparticle agents in the imaging and radiosensitization of tumors and overcoming challenges of therapeutic access through the blood brain barrier. This includes evaluation of the efficacy of novel radiotheranostic nanoparticle combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action.
Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK.: Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. J Neurooncol. 2020 Sep 10. doi: 10.1007/s11060-020-03618-1. Online ahead of print. PMID: 32914293
Frick MA, Feigenberg SJ, Jean-Baptiste SR, Aguarin LA, Mendes A, Chinniah C, Swisher-McClure S, Berman A, Levin W, Cengel KA, Hahn SM, Dorsey JF, Simone CB 2nd, Kao GD.: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clin Cancer Res. 2020 May 15;26(10):2372-2380. doi: 10.1158/1078-0432.CCR-19-2158. Epub 2020 Jan 22.
PMID: 31969332 : 2020.
Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26.
PMID: 31883794 : 2020.
Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK.: Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas. Mol Imaging Biol. 2020 Oct;22(5):1266-1279. doi: 10.1007/s11307-020-01504-w.
PMID: 32514886 : 2020.
Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M: A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment J Surg Oncol. : 2019.
Sheikh Saad, Saxena Deeksha, Tian Xiaobing, Amirshaghaghi Ahmad, Tsourkas Andrew, Brem Steven, Dorsey Jay F: An integrated stress response agent that modulates DR5 dependent TRAIL synergy reduces patient derived glioma stem cell viability. Molecular cancer research : MCR : 2019.
Saxena D, Sheikh S, Kao G, Binder ZA, Alonso-Basanta M, O'Rourke DM, Nasrallah MP, Dorsey JF.: Rapid and ultrasensitive digital PCR (dPCR) profiling of EGFRvIII in tumor cells and tissues. Neurooncol Adv. 2019 May-Dec;1(1):vdz030. doi: 10.1093/noajnl/vdz030. Epub 2019 Nov 28.
PMID: 31807732 : 2019.
Makhlin I, Salinas RD, Zhang D, Jacob F, Ming GL, Song H, Saxena D, Dorsey JF, Nasrallah MP, Morrissette JJ, Binder ZA, O'Rourke DM, Desai AS, Brem S, Bagley SJ.: Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma. CNS Oncol. 2019 Nov 1;8(3):CNS43. doi: 10.2217/cns-2019-0014. Epub 2019 Nov 15.
PMID: 31769726 : 2019.
Chinniah C, Aguarin L, Cheng P, Decesaris C, Cutillo A, Berman AT, Frick M, Doucette A, Cengel KA, Levin W, Hahn S, Dorsey JF, Simone CB 2nd, Kao GD.: Early Detection of Recurrence in Patients With Locally Advanced Non-Small-Cell Lung Cancer via Circulating Tumor Cell Analysis. Clin Lung Cancer. 2019 Sep;20(5):384-390.e2. doi: 10.1016/j.cllc.2019.04.011. Epub 2019 May 4.
PMID: 31221522 : 2019.
Liu Tianrun, Xu Haineng, Huang Menggui, Ma Wenjuan, Saxena Deeksha, Lustig Robert A, Alonso-Basanta Michelle, Zhang Zhenfeng, O'Rourke Donald M, Zhang Lin, Gong Yanqing, Kao Gary D, Dorsey Jay F, Fan Yi: Circulating Glioma Cells Exhibit Stem Cell-like Properties. Cancer research 78 (23): 6632-6642,2018.
Department of Radiation OncologyPerelman Center for Advanced MedicineBldg 421 SCTR 8-1353400 Civic Center Blvd
Patient appointments: 800-789-7366
Proton therapy is a non–invasive, incredibly precise cancer treatment that uses a beam of protons moving at very high speeds to destroy cancer cells.
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