Description of Research Expertise:
As a Physician-Scientist, I conduct brain tumor research and specialize in treatment of patients with intracranial malignancies. I have scientific expertise in the areas of signal transduction, molecular therapeutics, brain tumor biology, and radiation biology. As a translational researcher, I am actively involved in basic mechanistic studies, the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer, and early phase clinical trials in intracranial malignancies. In a broad sense, my research focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One research focus concerns the elucidation of mechanism(s) whereby the Integrated Stress Response (ISR) modulates death receptor expression, and leveraging this understanding therapeutically. A second area of focus is the identification and characterization of circulating tumor cells (CTCs) in the peripheral blood of cancer patients including those with primary brain tumors to gain prognostic and predictive information. Finally, my laboratory has an ongoing project focused on the application and preclinical testing of novel theranostic gold nanoparticle agents in the imaging and radiosensitization of tumors and overcoming challenges of therapeutic access through the blood brain barrier. This includes evaluation of the efficacy of novel radiotheranostic nanoparticle combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action.
Ajlan W. Al Zaki, David P. Cormode, Andrew Tsourkas, Jay F. Dorsey: Nanoparticle-enhanced Radiotherapy Increasing the Therapeutic Ratio of Radiotherapy : 2016.
Sun L, Joh DY, Al Zaki A, Stangl M, Murty S, Davis JJ, Baumann BC, Alonso-Basanta M, Kao GD, Tsourkas A, Dorsey JF: Theranostic application of mixed gold and superparamagnetic iron oxide nanoparticle micelles in glioblastoma multiforme J BIOMED NANOTECHNOL 12 : 347-356,2016.
Chowdhury IH, Ojerholm E, McMillan MT, Miller D, Kolker JD, Kurtz G, Dorsey
JF, Nagda SN, Geiger GA, Brem S, O'Rourke DM, Zager EL, Gangadhar T, Schuchter L,
Lee JY, Alonso-Basanta M: Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases RADIAT ONCOL 10 (1): 248,2015.
Xu MJ, Dorsey JF, Amaravadi R, Karakousis G, Simone CB 2nd, Xu X, Xu W, Carpenter EL, Schuchter L, Kao GD: Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma THE ONCOLOGIST 21 (1): 84-94,2015.
Vogel J, Ojerholm E, Hollander A, Briola C, Mooij R, Bieda M, Kolker J, Nagda S, Geiger G, Dorsey J, Lustig R, O'Rourke DM, Brem S, Lee J, Alonso-Basanta M: Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases RADIAT ONCOL 10 (1): 221,2015.
Simone CB and Dorsey JF: Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy ANN TRANSL MED : 2015.
Ojerhom E, Lee JYK, Thawani JP, Miller D, O'Rourke DM, Dorsey JF, Geiger GA, Nagda S, Kolker J, Lustig RA, Alonso-Basanta M: Stereotactic radiosurgery to the resection bed for intracranial metastases and risk of leptomeningeal carcinomatosis JOURNAL OF NEUROSURGERY 121 (Suppl): 75-83,2014.
McQuade C, Al Zaki A, Desai Y, Vido M, Sakhuja T, Cheng Z, Hickey RJ, Joh D, Park SJ, Kao G, Dorsey JF, Tsourkas A.: A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction of Therapeutic Response. SMALL 11 (7): 834-43,2014.
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