Description of Research Expertise:
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Tao JQ, Sorokina EM, Vazquez Medina JP, Mishra MK, Yamada Y, Satalin J, Nieman GF, Nellen JR, Beduhn B, Cantu E, Habashi NM, Jungraithmayr W, Christie JD, Chatterjee S.: Onset of Inflammation with Ischemia: Implications for Donor Lung Preservation and Transplant Survival American Journal of Transplantation : 2016 [Epub ahead of print].
Shashaty Michael G S, Reilly John P, Sims Carrie A, Holena Daniel N, Qing Danielle, Forker Caitlin M, Hotz Meghan J, Meyer Nuala J, Lanken Paul N, Feldman Harold I, Christie Jason D, Mangalmurti Nilam S: Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients. Shock (Augusta, Ga.) 46 (2): 139-43,2016.
Diamond Joshua M, Arcasoy Selim, McDonnough Jamiela A, Sonett Joshua R, Bacchetta Matthew, D'Ovidio Frank, Cantu Edward, Bermudez Christian A, McBurnie Amika, Rushefski Melanie, Kalman Laurel H, Oyster Michelle, D'Errico Carly, Suzuki Yoshikazu, Giles Jon T, Ferrante Anthony, Lippel Matthew, Singh Gopal, Lederer David J, Christie Jason D: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2016.
Yehya Nadir, Thomas Neal J, Meyer Nuala J, Christie Jason D, Berg Robert A, Margulies Susan S: Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. Intensive care medicine 42 (7): 1137-45,2016.
Monticelli Laurel A, Buck Michael D, Flamar Anne-Laure, Saenz Steven A, Tait Wojno Elia D, Yudanin Naomi A, Osborne Lisa C, Hepworth Matthew R, Tran Sara V, Rodewald Hans-Reimer, Shah Hardik, Cross Justin R, Diamond Joshua M, Cantu Edward, Christie Jason D, Pearce Erika L, Artis David: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature immunology 17 (6): 656-65,2016.
Porteous Mary K, Ky Bonnie, Kirkpatrick James N, Shinohara Russell, Diamond Joshua M, Shah Rupal J, Lee James C, Christie Jason D, Kawut Steven M: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant. American journal of respiratory and critical care medicine 193 (12): 1392-400,2016.
Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcaso S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, and Christie JD: The Relationship Between Plasma Lipid Peroxidation Products and Primary Graft Dysfunction After Lung Transplantation is Modified by Donor Smoking and Reperfusion Hyperoxia. American Journal of Transplantation 35 (4): 500-7,2016.
Diamond Joshua M, Porteous Mary K, Jackson Roberts L, Wickersham Nancy, Rushefski Melanie, Kawut Steven M, Shah Rupal J, Cantu Edward, Lederer David J, Chatterjee Shampa, Lama Vibha N, Bhorade Sangeeta, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Weinacker Ann, Arcasoy Selim, Shah Pali D, Wilkes David S, Hage Chadi, Palmer Scott M, Snyder Laurie, Calfee Carolyn S, Ware Lorraine B, Christie Jason D: The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 35 (4): 500-7,2016.
Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (3): 833-40,2016.
Palakshappa Jessica A, Anderson Brian J, Reilly John P, Shashaty Michael G S, Ueno Ryo, Wu Qufei, Ittner Caroline A G, Tommasini Anna, Dunn Thomas G, Charles Dudley, Kazi Altaf, Christie Jason D, Meyer Nuala J: Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Critical care (London, England) 20 (1): 71,2016.
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