Description of Research Expertise:
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Tao JQ, Sorokina EM, Vazquez Medina JP, Mishra MK, Yamada Y, Satalin J, Nieman GF, Nellen JR, Beduhn B, Cantu E, Habashi NM, Jungraithmayr W, Christie JD, Chatterjee S.: Onset of Inflammation with Ischemia: Implications for Donor Lung Preservation and Transplant Survival American Journal of Transplantation : 2016 [Epub ahead of print].
Porteous MK, Ky B, Kirkpatrick JN, Shinohara R, Diamond JM, Shah RJ, Lee JC, Christie JD, Kawut SM: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction After Lung Transplantation Am J Respir Crit Care Med : 2016 [Epub ahead of print].
Shashaty MG, Reilly JP, Sims CA, Holena DN, Qing D, Forker CM, Hotz MJ, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS.: Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients Shock : 2016 [Epub ahead of print].
Yehya N, Thomas NJ, Meyer NJ, Christie JD, Berg RA, Margulies SS.: Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome Intensive Care Medicine 42 (7): 1137-45,2016.
Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D.: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation Nature Immunology 17 (6): 656-65,2016.
Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcaso S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, and Christie JD: The Relationship Between Plasma Lipid Peroxidation Products and Primary Graft Dysfunction After Lung Transplantation is Modified by Donor Smoking and Reperfusion Hyperoxia. American Journal of Transplantation 35 (4): 500-7,2016.
Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (3): 833-40,2016.
Diamond J M, Shah R J, Cantu E, Porteous M K, Christie J D: Survey of Lung Transplant Community's Views on Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (2): 724-6,2016.
Palakshappa Jessica A, Anderson Brian J, Reilly John P, Shashaty Michael G S, Ueno Ryo, Wu Qufei, Ittner Caroline A G, Tommasini Anna, Dunn Thomas G, Charles Dudley, Kazi Altaf, Christie Jason D, Meyer Nuala J: Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Critical care (London, England) 20 (1): 71,2016.
Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal N, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ: Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation American Journal of Respiratory and Critical Care Medicine 192 (11): 1325-34,2015.
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