Description of Research Expertise:
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M, Diamond Joshua M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society : 2017.
Borders CF, Suzuki Y, Lasky J, Schaufler C, Mallem D, Lee J, Carney K, Bellamy SL, Bermudez CA, Localio AR, Christie JD, Diamond JM, Cantu E: Massive Donor Transfusion Potentially Increases Recipient Mortality After Lung Transplantation. Journal of Thoracic Cardiovascular Surgery 153 (5): 1197-1203,2017.
Lama Vibha N, Belperio John A, Christie Jason D, El-Chemaly Souheil, Fishbein Michael C, Gelman Andrew E, Hancock Wayne W, Keshavjee Shaf, Kreisel Daniel, Laubach Victor E, Looney Mark R, McDyer John F, Mohanakumar Thalachallour, Shilling Rebecca A, Panoskaltsis-Mortari Angela, Wilkes David S, Eu Jerry P, Nicolls Mark R: Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI insight 2 (9): 2017.
Holena Daniel N, Kaufman Elinore J, Delgado M Kit, Wiebe Douglas J, Carr Brendan G, Christie Jason D, Reilly Patrick M: A Metric of Our Own: Failure to Rescue After Trauma. The journal of trauma and acute care surgery : 2017.
Patterson KC, Shah RJ, Porteous MK, Christie JD, D'Errico C, Chadwick M, Triano M, Deshpande C, Rossman MD, Litzky LA, Kreider ME, Miller WT Jr: Interstitial Lung Disease in the Elderly. Chest 151 (4): 838-844,2017.
Baldwin Matthew R, Singer Jonathan P, Huang Debbie, Sell Jessica, Gonzalez Wendy C, Pollack Lauren, Maurer Mathew S, D'Ovidio Frank F, Bacchetta Matthew, Sonett Joshua R, Arcasoy Selim M, Shah Lori, Robbins Hilary, Hays Steven R, Kukreja Jasleen, Greenland John R, Shah Rupal J, Leard Lorriana, Morrell Matthew, Gries Cynthia, Katz Patricia P, Christie Jason D, Diamond Joshua M, Lederer David J: Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Annals of the American Thoracic Society : 2017.
Tong Y, Udupa JK, Torigian DA, Odhner D, Wu C, Pednekar G, Palmer S, Rozenshtein A, Shirk MA, Newell JD, Porteous M, Diamond JM, Christie JD, Lederer DJ: Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates. PLoS One 12 (1): e0168932,2017.
Diamond JM, Arcasoy S, McDonnough JA, Sonett JR, Bacchetta M, D'Ovidio F, Cantu E, Bermudez CA, McBurnie A, Rushefski M, Kalman LH, Oyster M, D'Errico C, Suzuki Y, Giles JT, Ferrante A, Lippel M, Singh G, Lederer DJ, Christie JD: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17 (1): 239-245,2017.
Diamond JM, Cantu E, Porteous M, Suzuki Y, Meyer KC, Lederer D, Milewski RK, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett JR, Singh G, Costa J, Tobias JW, Rodriguez H, Van Deerlin VM, Olthoff KM, Shaked A, Chang BL, Christie JD: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplant Epub ahead of Print : 2017.
Anderson BJ, Reilly JP, Shashaty MG, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission Plasma Levels of the Neuronal Injury Marker Neuron-specific Enolase are Associated with Mortality and Delirium in Sepsis. Journal of Critical Care 36 : 18-23,2016.
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