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Jason D. Christie, MD, MS

Jason D. Christie, MD, MS Physician

Chief, Medical Critical Care Section , Pulmonary, Allergy and Critical Care Division
Robert M. Kotloff/Nancy Blumenthal Professor for Advanced Lung Disease
Professor of Epidemiology in Biostatistics and Epidemiology

Dr. Christie is a Penn Medicine employed physician.

About Dr. Jason D. Christie

Recognized in Philadelphia Magazine's annual Top Docs issue from 2010 through 2016

Recognized by America's Top Doctors, 2012-14

Clinical Specialties

Specialty:

  • Medicine
    • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2000
  • Internal Medicine, 1996
  • Pulmonary Disease, 1999

Clinical Expertise:

  • Critical Care Medicine
  • Lung Disease
  • Lung Injury

Practice Locations and Appointments

  • Harron Lung Center

    Perelman Center for Advanced Medicine West Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Columbia University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Board of Internal Medicine, National American College of Chest Physicians, National American College of Epidemiology, National American College of Physicians, National American Society of Transplantation, National American Thoracic Society, National Board of Directors: The ARDS Foundation (www.ARDSUSA.org), National Drinker Critical Care Society, Local International Society for Heart and Lung Transplantation, International International Society for Heart and Lung Transplantation, International International Society of Heart and Lung Transplant (ISHLT), International International Society of Heart and Lung Transplantation Fellowship, International International Society of Heart and Lung Transplantation, International Laennec Society, Local NHLBI Science Moving Towards Research Translation and Therapy (SMARTT) program, National Pennsylvania Thoracic Society, Local Society for Epidemiologic Research, International Society of Critical Care Medicine, International

Hospital Affiliation

Dr. Christie is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications:

Tao JQ, Sorokina EM, Vazquez Medina JP, Mishra MK, Yamada Y, Satalin J, Nieman GF, Nellen JR, Beduhn B, Cantu E, Habashi NM, Jungraithmayr W, Christie JD, Chatterjee S.: Onset of Inflammation with Ischemia: Implications for Donor Lung Preservation and Transplant Survival American Journal of Transplantation : 2016 [Epub ahead of print].

Shashaty Michael G S, Reilly John P, Sims Carrie A, Holena Daniel N, Qing Danielle, Forker Caitlin M, Hotz Meghan J, Meyer Nuala J, Lanken Paul N, Feldman Harold I, Christie Jason D, Mangalmurti Nilam S: Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients. Shock (Augusta, Ga.) 46 (2): 139-43,2016.

Diamond Joshua M, Arcasoy Selim, McDonnough Jamiela A, Sonett Joshua R, Bacchetta Matthew, D'Ovidio Frank, Cantu Edward, Bermudez Christian A, McBurnie Amika, Rushefski Melanie, Kalman Laurel H, Oyster Michelle, D'Errico Carly, Suzuki Yoshikazu, Giles Jon T, Ferrante Anthony, Lippel Matthew, Singh Gopal, Lederer David J, Christie Jason D: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons : 2016.

Yehya Nadir, Thomas Neal J, Meyer Nuala J, Christie Jason D, Berg Robert A, Margulies Susan S: Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. Intensive care medicine 42 (7): 1137-45,2016.

Monticelli Laurel A, Buck Michael D, Flamar Anne-Laure, Saenz Steven A, Tait Wojno Elia D, Yudanin Naomi A, Osborne Lisa C, Hepworth Matthew R, Tran Sara V, Rodewald Hans-Reimer, Shah Hardik, Cross Justin R, Diamond Joshua M, Cantu Edward, Christie Jason D, Pearce Erika L, Artis David: Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature immunology 17 (6): 656-65,2016.

Porteous Mary K, Ky Bonnie, Kirkpatrick James N, Shinohara Russell, Diamond Joshua M, Shah Rupal J, Lee James C, Christie Jason D, Kawut Steven M: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant. American journal of respiratory and critical care medicine 193 (12): 1392-400,2016.

Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcaso S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, and Christie JD: The Relationship Between Plasma Lipid Peroxidation Products and Primary Graft Dysfunction After Lung Transplantation is Modified by Donor Smoking and Reperfusion Hyperoxia. American Journal of Transplantation 35 (4): 500-7,2016.

Diamond Joshua M, Porteous Mary K, Jackson Roberts L, Wickersham Nancy, Rushefski Melanie, Kawut Steven M, Shah Rupal J, Cantu Edward, Lederer David J, Chatterjee Shampa, Lama Vibha N, Bhorade Sangeeta, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Weinacker Ann, Arcasoy Selim, Shah Pali D, Wilkes David S, Hage Chadi, Palmer Scott M, Snyder Laurie, Calfee Carolyn S, Ware Lorraine B, Christie Jason D: The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 35 (4): 500-7,2016.

Cantu E, Suzuki Y, Diamond J M, Ellis J, Tiwari J, Beduhn B, Nellen J R, Shah R, Meyer N J, Lederer D J, Kawut S M, Palmer S M, Snyder L D, Hartwig M G, Lama V N, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah P D, Weinacker A, Weill D, Wilkes D, Roe D, Ware L B, Wang F, Feng R, Christie J D: Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16 (3): 833-40,2016.

Palakshappa Jessica A, Anderson Brian J, Reilly John P, Shashaty Michael G S, Ueno Ryo, Wu Qufei, Ittner Caroline A G, Tommasini Anna, Dunn Thomas G, Charles Dudley, Kazi Altaf, Christie Jason D, Meyer Nuala J: Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Critical care (London, England) 20 (1): 71,2016.

View all publications

Academic Contact Info

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
717 Blockley Hall

Philadelphia, PA 19104
Phone: (215) 573-3209
Fax: (215) 573-0198
Patient appointments: 800-789-PENN (7366)

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