Description of Research Expertise:
Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.
Panzer Ariane R, Lynch Susan V, Langelier Chaz, Christie Jason D, McCauley Kathryn, Nelson Mary, Cheung Christopher K, Benowitz Neal L, Cohen Mitchell J, Calfee Carolyn S: Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients. American journal of respiratory and critical care medicine : 2017.
Snell Gregory I, Yusen Roger D, Weill David, Strueber Martin, Garrity Edward, Reed Anna, Pelaez Andres, Whelan Timothy P, Perch Michael, Bag Remzi, Budev Marie, Corris Paul A, Crespo Maria M, Witt Chad, Cantu Edward, Christie Jason D: Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: Definition and grading-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 36 (10): 1097-1103,2017.
Meyer Nuala J, Reilly John P, Anderson Brian J, Palakshappa Jessica A, Jones Tiffanie K, Dunn Thomas G, Shashaty Michael G S, Feng Rui, Christie Jason D, Opal Steven M: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Critical care medicine : 2017.
Khan Akram, Benthin Cody, Zeno Brian, Albertson Timothy E, Boyd John, Christie Jason D, Hall Richard, Poirier Germain, Ronco Juan J, Tidswell Mark, Hardes Kelly, Powley William M, Wright Tracey J, Siederer Sarah K, Fairman David A, Lipson David A, Bayliffe Andrew I, Lazaar Aili L: A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Critical care (London, England) 21 (1): 234,2017.
Cantu Edward, Diamond Joshua M, Suzuki Yoshikazu, Lasky Jared, Schaufler Christian, Lim Brian, Shah Rupal, Porteous Mary, Lederer David J, Kawut Steven M, Palmer Scott M, Snyder Laurie D, Hartwig Matthew G, Lama Vibha N, Bhorade Sangeeta, Bermudez Christian, Crespo Maria, McDyer John, Wille Keith, Orens Jonathan, Shah Pali D, Weinacker Ann, Weill David, Wilkes David, Roe David, Hage Chadi, Ware Lorraine B, Bellamy Scarlett L, Christie Jason D: Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction After Lung Transplant. American journal of respiratory and critical care medicine : 2017.
Miano Todd A, Cuker Adam, Christie Jason D, Martin Niels, Smith Brian, Makley Amy T, Guo Wensheng, Hennessy Sean: Comparative Effectiveness of Enoxaparin vs Dalteparin for Thromboprophylaxis After Traumatic Injury. Chest : 2017.
Winterbottom Christopher J, Shah Rupal J, Patterson Karen C, Kreider Maryl E, Panettieri Reynold A, Rivera-Lebron Belinda, Miller Wallace T, Litzky Leslie A, Penning Trevor M, Heinlen Krista, Jackson Tara, Localio A Russell, Christie Jason D: Exposure to Ambient Particulate Matter Is Associated With Accelerated Functional Decline in Idiopathic Pulmonary Fibrosis. Chest : 2017.
Akimova Tatiana, Zhang Tianyi, Negorev Dmitri, Singhal Sunil, Stadanlick Jason, Rao Abhishek, Annunziata Michael, Levine Matthew H, Beier Ulf H, Diamond Joshua M, Christie Jason D, Albelda Steven M, Eruslanov Evgeniy B, Hancock Wayne W: Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI insight 2 (16): 2017.
Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M, Diamond Joshua M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society 14 (10): 1514-1522,2017.
Borders CF, Suzuki Y, Lasky J, Schaufler C, Mallem D, Lee J, Carney K, Bellamy SL, Bermudez CA, Localio AR, Christie JD, Diamond JM, Cantu E: Massive Donor Transfusion Potentially Increases Recipient Mortality After Lung Transplantation. Journal of Thoracic Cardiovascular Surgery 153 (5): 1197-1203,2017.
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