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James D. Lewis, MD, MSCE

James D. Lewis, MD, MSCE Physician

Associate Director, Inflammatory Bowel Disease Program Professor of Medicine Professor of Epidemiology in Biostatistics and Epidemiology

Dr. Lewis is employed by Penn Medicine.

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About Dr. James D. Lewis

Recognized in Philadelphia magazine's Top Docs issues in 2010 and 2017

Recognized by Best Doctors in America - 2013-2014

Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 1997

Clinical Expertise:

  • Colonoscopy
  • Crohn's Disease
  • Inflammatory Bowel Disease (IBD)
  • Ulcerative Colitis (Colitis Ulcerosa, UC)
  • Upper GI Endoscopy

Description of Clinical Expertise

Gastroenterology, IBD, Colon Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Yale-New Haven Hospital
Fellowship: Hospital of the University of Pennsylvania


American College of Epidemiology, National American College of Gastroenterology, National American College of Physicians, National American Gastroenterological Association (Fellow), National American Society for Clinical Investigation, National Association of American Physicians, National Broad Medical Research Program, National BUPA Foundation - United Kingdom, International Crohn's and Colitis Foundation of America , National Future Leaders in IBD Research Program, International Gilead Sciences, Inc. , International Gilead, International International Conference for Pharmacoepidemiology Program Committee - 2003- 2005, 2008-2010, International International Organization for the Study of Inflammatory Bowel Disease, International International Society of Pharmacoepidemiology, International National Board of Medical Examiners Computer-based Case Simulation Quality Control Task Force, National National Institute for Health Research - United Kingdom, International National Institutes of Health - Small Clinical Research Grants in Digestive Diseases and Nutrition Study Section - 2003, 2004, National National Institutes of Health , National National Institutes of Health, National NIH, National NIH, National NIH, National Pfizer, International SYNSORB Biotech, Inc, National UCB, International UCB, International University of Pennsylvania and NIH, National University of Pennsylvania Cancer Center, Local

Hospital Affiliation

Dr. Lewis is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Epidemiology, IBD, Colon Cancer

Selected Publications:

Goldberg D, Lewis JD, Halpern SD, Weiner M, Lo Re V: Validation of three coding algorithms to identify patients with end-stage liver disease in an administrative database Pharmacoepidemiol Drug Saf 22 (1): 103-7,2013 .

Scott Frank I, Osterman Mark T, McConnell Ryan A, Lorusso Monica, Aberra Faten, Kerner Caroline, Lichtenstein Gary R, Lewis James D: Impact of JC Virus Antibody Testing in Patients with Crohn's Disease with Loss of Response to Infliximab: A Markov Model. Inflammatory bowel diseases 19 (12): 2625-33,2013.

Kappelman Michael D, Long Millie D, Martin Christopher, Dewalt Darren A, Kinneer Patricia M, Chen Wenli, Lewis James D, Sandler Robert S: Evaluation of the Patient Reported Outcomes Measurement Information System in a large cohort of patients with Inflammatory Bowel Diseases. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 12 (8): 1315-23,2014.

Li Dan, Collins Bernadette, Velayos Fernando S, Liu Liyan, Lewis James D, Allison James E, Flowers Nicole T, Hutfless Susan, Abramson Oren, Herrinton Lisa J: Racial and Ethnic Differences in Health Care Utilization and Outcomes Among Ulcerative Colitis Patients in an Integrated Health-Care Organization. Digestive diseases and sciences 59 (2): 287-94,2013.

Solomon Daniel H, Curtis Jeffrey R, Saag Kenneth G, Lii Joyce, Chen Lang, Harrold Leslie R, Herrinton Lisa J, Graham David J, Kowal Mary K, Kuriya Bindee, Liu Liyan, Griffin Marie R, Lewis James D, Rassen Jeremy A: Cardiovascular Risk in Rheumatoid Arthritis: Comparing TNF-α Blockade with Nonbiologic DMARDs. The American journal of medicine 126 (8): 730.e9-730.e17,2013.

Baddley John W, Winthrop Kevin L, Chen Lang, Liu Liyan, Grijalva Carlos G, Delzell Elizabeth, Beukelman Timothy, Patkar Nivedita M, Xie Fenglong, Saag Kenneth G, Herrinton Lisa J, Solomon Daniel H, Lewis James D, Curtis Jeffrey R: Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) Study. Annals of the rheumatic diseases 73 (11): 1942-8,2014.

Minot Samuel, Bryson Alexandra, Chehoud Christel, Wu Gary D, Lewis James D, Bushman Frederic D: Rapid evolution of the human gut virome. Proceedings of the National Academy of Sciences of the United States of America 110 (30): 12450-5,2013.

Osterman Mark T, Haynes Kevin, Delzell Elizabeth, Zhang Jie, Bewtra Meenakshi, Brensinger Colleen, Chen Lang, Xie Fenlong, Curtis Jeffrey R, Lewis James D: Comparative Effectiveness of Infliximab and Adalimumab for Crohn's Disease. Clinical Gastroenterology and Hepatology 12 (5): 811-817,2014.

Zhang Jie, Xie Fenglong, Delzell Elizabeth, Chen Lang, Kilgore Meredith L, Yun Huifeng, Saag Kenneth G, Lewis James D, Curtis Jeffrey R: Trends in the Use of Biologic Therapies among Rheumatoid Arthritis Patients Enrolled in the U.S. Medicare Program. Arthritis Care & Research 65 (11): 1743-51,2013.

Koeth Robert A, Wang Zeneng, Levison Bruce S, Buffa Jennifer A, Org Elin, Sheehy Brendan T, Britt Earl B, Fu Xiaoming, Wu Yuping, Li Lin, Smith Jonathan D, Didonato Joseph A, Chen Jun, Li Hongzhe, Wu Gary D, Lewis James D, Warrier Manya, Brown J Mark, Krauss Ronald M, Tang W H Wilson, Bushman Frederic D, Lusis Aldons J, Hazen Stanley L: Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine 19 (5): 576-85,2013.

View all publications

Academic Contact Info

University of Pennsylvania
Division of Gastroenterology
Center for Clinical Epidemiology and Biostatistics
423 Guardian Drive
720 Blockley Hall

Philadelphia, PA 19104-6021
Phone: (215) 573-5137
Fax: (215) 573-0813
Patient appointments: 800-789-7366 (PENN)

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