Description of Research Expertise:
I am an MD-PhD clinician-scientist with medical and scientific interest in the molecular enhancement of bone formation and fracture healing and the outcomes of orthopaedic trauma and fracture treatment. My investigative goals include the identification of interventions (biological, mechanical/surgical, decision-making) that improve patient care, to better understand them in the laboratory and to adapt them to the patient population that I treat. To those ends, I work with several interdisciplinary teams consisting of biologists, engineers, surgeons, veterinarians, clinical investigators to enhance our understanding and provision of orthopaedic care.
>> Gene regulation in bone healing - Using my background in molecular biology and gene regulation, I have delved into the investigation of a number of pathways and processes in bone healing and regulation—consistent and synergistic with my orthopaedic trauma practice. I utilize primarily mouse models of traumatic fracture healing (with my collaborator, Kurt Hankenson) and have studies pathways related to thrombospondins, Wnt and Notch; and I have been especially interested in the geriatric condition (both fractures and bone loss as suggested by references). Select publications (5 years):
• Ashley JW, Ahn J, Hankenson KD. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015 Nov;116(11):2598-609.
• Lopas LA, Belkin NS, Mutyaba PL, Gray CF, Hankenson KD, Ahn J. Fractures in geriatric mice show decreased callus expansion and bone volume. Clin Orthop Relat Res. 2014 Nov;472(11):3523-32.
• Mutyaba PL, Belkin NS, Lopas L, Gray CF, Dopkin D, Hankenson KD, Ahn J. Notch signaling in mesenchymal stem cells harvested from geriatric mice. J Orthop Trauma. 2014;28 Suppl 1:S20-3.
• Dishowitz MI, Mutyaba PL, Takacs JD, Barr AM, Engiles JB, Ahn J, Hankenson KD. Systemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One. 2013 Jul 3;8(7):e68726.
• Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD. Disruption of thrombospondin-2 accelerates ischemic fracture healing. J Orthop Res. 2013 Jun;31(6):935-43.
>> Improving paradigms of medical decision-making - My scientific investigations have led me to become involved in the systematic analysis of outcomes data (multiple publications) and the systematic dissemination of education and information regarding evidence-based medicine. My collaborator, Joseph Bernstein, and I have taken this a step further and asked how to take medical decision-making into the future by not only incorporation what we know but exploring new methods to created better paradigms to come to better clinical conclusions. Select publications (5 years):
• Bernstein J, Kupperman E, Kandel LA, Ahn J. Shared Decision Making, Fast and Slow: Implications for Informed Consent, Resource Utilization, and Patient Satisfaction in Orthopaedic Surgery. J Am Acad Orthop Surg. 2016 May 25.
• Bernstein J, Morshed S, Helfet DL, Bhandari M, Ahn J. Applying evidence-based medicine principles to hip fracture management. Front Surg. 2014 Oct 20;1:40.
• Baldwin KD, Bernstein J, Ahn J, McKay SD, Sankar WN. Level of evidence gap in orthopedic research. Orthopedics. 2012 Sep;35(9):e1416-9.
• Bernstein J, Long JS, Veillette C, Ahn J. Crowd intelligence for the classification of fractures and beyond. PLoS One. 2011;6(11):e27620.
• Bernstein J, Ahn J, Veillette C. The future of orthopaedic information management. J Bone Joint Surg Am. 2012 Jul 3;94(13):e95.
>> Medical education (especially, the clinician-scientist) - Advances in biomedicine are driven by clinically minded scientists and scientifically minded clinicians. I have been studying, refining, improving, advocating for greater data-driven education and resource allocation for the training of medical scientists and clinician-scientists from the stages of undergraduate medical education and throughout graduate training. Select publications (5 years):
• Schenker ML, Baldwin KD, Israelite CL, Levin LS, Mehta S, Ahn J. Selecting the Best and Brightest: A Structured Approach to Orthopedic Resident Selection. J Surg Educ. 2016 May 23.
• Daye D, Patel CB, Ahn J, Nguyen FT. Challenges and opportunities for reinvigorating the physician-scientist pipeline. J Clin Invest. 2015 Mar 2;125(3):883-7.
• Ahn J. Letter to the editor: Editorial: Transition from training to practice--is there a better way? Clin Orthop Relat Res. 2014 Sep;472(9):2887-8.
• Atesok KI, Hurwitz SR, Egol KA, Ahn J, Owens BD, Crosby LA, Pellegrini VD Jr. Perspective: Integrating research into surgical residency education: lessons learned from orthopaedic surgery. Acad Med. 2012 May;87(5):592-7.
• Baldwin K, Namdari S, Bowers A, Keenan MA, Levin LS, Ahn J. Factors affecting interest in orthopedics among female medical students: a prospective analysis. Orthopedics. 2011 Dec 6;34(12):e919-32.
>> The Practice of orthopaedic surgery. Select publications (5 years):
• Bernstein J, Roberts FO, Wiesel BB, Ahn J. Preoperative Testing for Hip Fracture Patients Delays Surgery, Prolongs Hospital Stays, and Rarely Dictates Care. J Orthop Trauma. 2016 Feb;30(2):78-80.
• Sagi HC / Ahn J, Ciesla D, Collinge C, Molina C, Obremskey WT, Guillamondegui O, Tornetta P 3rd; Orthopaedic Trauma Association Evidence Based Quality Value and Safety Committee. Venous Thromboembolism Prophylaxis in Orthopaedic Trauma Patients: A Survey of OTA Member Practice Patterns and OTA Expert Panel Recommendations. J Orthop Trauma. 2015 Oct;29(10):e355-62.
• Sullivan MP, Baldwin KD, Donegan DJ, Mehta S, Ahn J. Geriatric fractures about the hip: divergent patterns in the proximal femur, acetabulum, and pelvis. Orthopedics. 2014 Mar;37(3):151-7.
• Scolaro JA, Schenker ML, Yannascoli S, Baldwin K, Mehta S, Ahn J. Cigarette smoking increases complications following fracture: a systematic review. J Bone Joint Surg Am. 2014 Apr 16;96(8):674-81.
• Schenker ML, Yannascoli S, Baldwin KD, Ahn J, Mehta S. Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review. J Bone Joint Surg Am. 2012 Jun 20;94(12):1057-64.
Schenker M, Baldwin K, Israelite CL, Levin LS, Mehta S, Ahn J: Development of a semi-structured interview to the orthopaedic residency selection process Journal of Surgical Education : 2016.
Pignolo R, Ahn J: Fractures in the elderly Fractures in the elderly : 2016.
Sullivan MP, Mehta S, Ahn J: Financial implications of 22 modifiers in orthopaedic trauma practice Journal of Health Economics : 2016.
Winterton M, Ahn, Bernstein J: The prevalence and cost of medical student visiting rotations BMC Medical Education : 2016.
Silvestre J, Ahn J, Levin LS: National Institutes of Health Funding to Departments of Orthopaedic Surgery at U.S. Medical Schools Journal of Bone and Joint Surgery : 2016.
Bernstein J, Kupperman E, Kandel LA, Ahn J: Shared Decision Making, Fast and Slow: Implications for Informed Consent, Resource Utilization, and Patient Satisfaction in Orthopaedic Surgery Journal of the American Academy of Orthopaedic Surgeons 24 : 495-502,2016.
Dunn R, Ahn J, Bernstein J: End-of-Life Care Planning and Fragility Fractures of the Hip: Are We Missing a Valuable Opportunity? Clinical Orthopaedics and Related Research 474 (7): 1736-9,2016.
Kaur G, Ahn J, Hankenson KD, Ashley JW.: Stimulation of Notch Signaling in Mouse Osteoclast Precursors. JoVE : 2016.
Bernstein JR, Ahn J, Mahili G, Bernstein J: Levels of Influence: Habituation and The Prevalence of Declared Conflicts of Interest Journal of Bone and Joint Surgery : 2016.
Anari JB, Ahn J, Kneeland B, Mehta S: The Utility of Digital Tomosynthesis to the Practicing Orthopaedic Trauma Surgeon: A Case Series Journal of Orthopaedic Trauma : 2015.