Jacob S Brenner, MD, PHD
he / him
Pulmonary Medicine
Sees patients age 18 and up
Harron Lung Center - Inpatient Care
Penn Medicine Provider

About me

  • Associate Director of Penn Health-Tech
  • Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
  • Assistant Professor of Medicine in Pharmacology

Dr. Brenner is a critical care physician.  He attends in the medical ICU at the Hospital of the University of Pennsylvania.  His research is developing nanomedicine for acute critical illnesses, including ARDS, stroke, sepsis, and more.

Education and training

  • Medical School: Stanford University
  • Medical School: Stanford University School of Medicine
  • Residency: Stanford University Medical Center
  • Fellowship: University of Pennsylvania Health System

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Brenner is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Patel MN, Tiwari S, Brenner JS. Preparation and Characterization of Lipid Nanoparticles Co-loaded With DNA and Nitro-Oleic Acid , Bio Protoc, 15(18): 2025,e5450


Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS. Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape , Nat Nanotechnol, 20(9): 2025,1285-1297


Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo , Proc Natl Acad Sci U S A, 122(29): 2025,e2409266122


Roth AM, D'Angelo AK, Gordon D, Cocchiaro B, Lingamoorthy A, Laurano R, Salzman M, Brenner JS, Baston C. Use of a Shoulder-Mounted Wearable Sensor Prototype Designed to Detect Opioid-Related Overdose: A Qualitative User Experience Study , J Med Internet Res, 27: 2025,e73566


Patel MN, Tiwari S, Brenner JS. Perspective: Advancing safe and effective DNA therapeutics using bioactive lipid nanoparticles , Mol Ther, 33(6): 2025,2324-2325


Tursi NJ, Tiwari S, Bedanova N, Kannan T, Parzych E, Okba N, Liaw K, Sárközy A, Livingston C, Trullen MI, Gary EN, Vadovics M, Laenger N, Londregan J, Khan MS, Omo-Lamai S, Muramatsu H, Blatney K, Hojecki C, Machado V, Maricic I, Smith TRF, Humeau LM, Patel A, Kossenkov A, Brenner JS, Allman D, Krammer F, Pardi N, Weiner DB. Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity , Cell Rep Med, 6(4): 2025,102035


Zhang Z, Xu C, Gong N, Qing G, Zhang Y, Shi Y, Brenner JS, Li F, Xu FJ, Liang XJ. An antigen-capturing and lymph node-targeting nanoparticle for cancer immunotherapy , J Control Release, 379: 2025,993-1005


Patel MN, Tiwari S, Wang Y, O'Neill S, Wu J, Omo-Lamai S, Espy C, Chase LS, Majumder A, Hoffman E, Shah A, Sárközy A, Katzen J, Pardi N, Brenner JS Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids , Nat Biotechnol: 2025


Zaleski MH, Chase LS, Hood ED, Wang Z, Nong J, Espy CL, Zamora ME, Wu J, Morrell LJ, Muzykantov VR, Myerson JW, Brenner JS. Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation , Adv Mater, 37(5): 2024,e2409945


Zaleski MH, Omo-Lamai S, Nong J, Chase LS, Myerson JW, Glassman PM, Lee F, Reyes-Esteves S, Wang Z, Patel MN, Peshkova AD, Komatsu H, Axelsen PH, Muzykantov VR, Marcos-Contreras OA, Brenner JS. Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy , J Control Release, 374: 2024,425-440


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