Penn Medicine Provider
Pulmonary Medicine
Jacob S Brenner, MD, PHD
he / him
Sees patients age 18 and up
Harron Lung Center - Inpatient Care

About me

  • Associate Director of Penn Health-Tech
  • Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
  • Assistant Professor of Medicine in Pharmacology

Dr. Brenner is a critical care physician.  He attends in the medical ICU at the Hospital of the University of Pennsylvania.  His research is developing nanomedicine for acute critical illnesses, including ARDS, stroke, sepsis, and more.

Education and training

  • Medical School: Stanford University
  • Medical School: Stanford University School of Medicine
  • Residency: Stanford University Medical Center
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Brenner is a Penn Medicine physician.

Qualifications and experience

My research

Zaleski MH, Chase LS, Hood ED, Wang Z, Nong J, Espy CL, Zamora ME, Wu J, Morrell LJ, Muzykantov VR, Myerson JW, Brenner JS. Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation , Adv Mater, 11: 2024,e2409945


Zaleski MH, Omo-Lamai S, Nong J, Chase LS, Myerson JW, Glassman PM, Lee F, Reyes-Esteves S, Wang Z, Patel MN, Peshkova AD, Komatsu H, Axelsen PH, Muzykantov VR, Marcos-Contreras OA, Brenner JS. Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy , J Control Release, 374: 2024,425-440


Rubey KM, Freeman A, Mukhitov AR, Paris AJ, Lin SM, Rue R, Fazelinia H, Spruce LA, Roof J, Brenner JS, Heimall J, Krymskaya VP. Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophils , Life Sci Alliance, 7: 2024,e202402618


Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Brenner JS, Muzykantov VR, Bakker J, Abella BS. Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass , Crit Care Med, 52(8): 2024,1239-1250


Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D. Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions , ACS Nano, 18(22): 2024,13983-13999


Lee HS, Kim YC, Wang Z, Brenner JS, Muzykantov VR, Myerson JW, Composto RJ. Controlling spatial distribution of functional lipids in a supported lipid bilayer prepared from vesicles , J Colloid Interface Sci, 664: 2024,1042-1055


Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke , Mol Ther, 32(5): 2024,1344-1358


Zamora ME, Omo-Lamai S, Patel MN, Wu J, Arguiri E, Muzykantov VR, Myerson JW, Marcos-Contreras OA, Brenner JS. Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting , Nano Lett: 2024,epub ahead of print


Ebrahimimojarad A, Wang Z, Zhang Q, Shah A, Brenner JS, Fu J. A Robust and Efficient Method to Purify DNA-Scaffolded Nanostructures by Gravity-Driven Size Exclusion Chromatography , Langmuir, 40(16): 2024,8365-8372


Omo-Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Majumder A, Melamed JR, Chase LS, Essien EO, Weissman D, Muzykantov VR, Marcos-Contreras OA, Myerson JW, Brenner JS. Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions , Adv Mater, 36(6): 2024,e2312026


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