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J. Eduardo Rame, MD Physician

Medical Director, Ventricular Assist Device Program
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Assistant Professor of Medicine in Surgery

Languages spoken:

  • Spanish

Dr. Rame is a Penn Medicine employed physician.

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Advanced Heart Failure and Transplant Cardiology, 2010

Clinical Expertise:

  • Heart Transplant - Post-Transplant Follow-Up
  • Heart Transplant Evaluation
  • Heart Transplantation
  • Hypertensive Heart Disease
  • Ischemic Heart Disease
  • Left-sided Heart Failure
  • Long Term Mechanical Circulatory Support
  • Right Sided Heart Failure
  • Temporary Mechanical Circulatory Support

Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: University of Texas Southwestern Medical Center
Fellowship: UT Southwestern Medical Center of Dallas
Fellowship: Johns Hopkins Hospital


American College of Cardiology, National American Heart Association, National American Institute of Biological Sciences, National Peer-Reviewed Medical Research Program for the US Army Medical Research and Material Command, National Heart Failure Society of America, National International Society for Heart and Lung Transplantation, International Massachusetts Medical Society, Local United Network for Organ Sharing (UNOS), National

Hospital Affiliation

Dr. Rame is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications:

Prashanth Vallabhajosyula, MD, MS, Matthew Kramer, BS, Sofiane Lazar, BS, Fenton McCarthy, MD,Eduardo Rame, MD, Joyce Wald, MD, Wilson Szeto, MD, Matthew Williams, MD, Pavan Atluri, MD, Nimesh Desai, MD, PhD, and Michael Acker, MD: Lower-extremity complications with femoral extracorporeal life support The Journal of Thoracic and Cardiovascular Surgery : 2016.

Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE: Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation 133 (8): 706-16,2016.

Birati EY, Mathelier H, Molina M, Hanff TC, Mazurek JA, Atluri P, Acker MA, Rame JE, Margulies KB, Goldberg LR, Jessup M: Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions =35% Versus >35. The American Journal of Cardiology S0002-9149 (16): 30150-3,2016.

Burkhoff D, Maurer MS, Joseph S, Rogers JG, Birati Eo, Rame JE, Shah SJ: Reply: Is Pump the Answer to Heart Failure With Preserved Ejection Fraction? JACC Heart Fail 4 (1): 93,2016.

Rame JE: Metabolic Staging in Human Heart Failure: Circulating Acylcarnitines and the Failing Heart's Energetic Signature. J Am Coll cardiol 67 (3): 300-2,2016.

Stewart GC, Kittleson MM, Cowger JA, Johnson FL, Patel CB, Mountis MM, Patel PC, Rame JE, Testani J, Guglin ME, Teuteberg JJ, Stevenson LW: Who wants a left ventricular assist device for ambulatory heart failure? Early insights from the MEDAMACS screening pilot. J Heart Lung Transplant 34 (12): 1630-3,2015.

McCarthy FH, Kobrin D, Rame JE, Groeneveld PW, McDermott KM, Atluri P, Acker MA, Desai ND: Increasing Frequency of Left Ventricular Assist Device Exchanges in the United States. Annals of Thoracic Surgery 100 (5): 1660-4; discussion 1665,2015.

Bermudez CA, Rame JE: Reversible but risky: Pulmonary hypertension in advanced heart failure is the Achilles' heel of cardiac transplantation. J Thorac Cardiovasc Surg 150 (5): 1362-3,2015.

Rame JE, Birati EY: HeartWare Left Ventricular Assist Device Pump Thrombosis: A Shift Away From Ramp. JACC Heart Fail 3 (11): 857-9,2015.

Teuteberg JJ, MD, Slaughter MS, Rogers JG, McGee EC, Pagani FD, Gordon R, Rame E, Acker M, Kormos RL, Salerno C, Schleeter TP, Goldstein DJ, Shin J, Starling RC, Wozniak T, Malik AS, Silvestry S, Ewald GA, Jorde UP, Naka Y, Birks E, Najarian KB, Hathaway DR, Aaronson KD: The HVAD Left Ventricular Assist Device: Risk Factors for Neurologic Events and Preventative Mitigation Strategies. JACC Heart Failure 3 (10): 818-28,2015.

Academic Contact Info

Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 615-7949
Fax: (215) 349-5603
Patient appointments: 800-789-PENN (7366)

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