Description of Research Expertise:
My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.
Han JJ, Chen C, Chung J, Gaffey AC, Sotolongo A, Justice CM, Rame JE, Bermudez C, Acker MA: ECMO-Bridge to LVAD Therapy Is a Safe and Effective Strategy for Critically Ill Patients. The Journal of Heart and Lung Transplantation 36 (4): S328,2017.
Hanff TC, Mazurek JA, Grandin EW, Padegimas A, Howard J, Forde-McLean R, Wald J, Acker MA, Goldberg LR, Atluri P, Rame JE, Jessup M, Margulies KB: The Anemic Stress Index - A Novel Index that Predicts Short and Long Term Mortality of Patients on Continuous Flow Ventricular Assist Devices. The Journal of Heart and Lung Transplantation 36 (4): S173–S174,2017.
Padegimas A, Pak ES, Hanff TC, Mazurek JA, Seigerman ME, Menachem J, Marble J, Goldberg LR, Wald J, Atluri P, Rame JE: Peak Oxygen Consumption and VE/VCO2 Correlates with 6 Minutes' Walk Test in Patients Supported with Continuous Flow LVAD.
The Journal of Heart and Lung Transplantation 36 (4): S436–S437,2017.
Grandin E, Mooney D, Kennedy DK, Kiernan MS, Kociol RD, Teuteberg JJ, Pagani FD, Gaffey AC, Atluri P, Birati E, Myers S, Naftel D, Oliveira G, Simpson KE, Yeh RW, Kirklin JK, Kormos RL: The Duration of Inotropic Support and Survival After Left Ventricular Assist Device. The Journal of Heart and Lung Transplantation 36 (4): S140–S141,2017.
Gentile JI, Molina, Atluri P, Rame JE, Wald JW, Birati EY, Goldberg LR, McLean R, Acker MI: ECMO Use in INTERMACS 1 Patients as a Bridge to LVAD with Intention to Transplant versus Bridge to Direct Heart Transplant. Single Center Experience. The Journal of Heart and Lung Transplantation 36 (4): S337,2017.
Chung JJ, Stetson R, Chen CW, Gaffey AC, Rame J, Acker MA: Doing the Math: The Costs of Long Term Mechanical Circulatory Support. The Journal of Heart and Lung Transplantation 36 (4): S287,2017.
Gentile JI, Atluri P, Desai ND, Vallabhajosyula p, Wald JW, Rame JE, Gutsche JT, Horak J, Acker MI: Outcomes of Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock in the Elderly. Large Single Center Experience. The Journal of Heart and Lung Transplantation 36 (4): S339,2017.
Han JJ, Sooppan R, Johnson AP, Chen CW, Gaffey AC, Phillips EC, Howard J, Rame JE, Acker MA: Higher Body Mass Index Increases Risk of HeartMate II Pump Thrombosis But Does Not Adversely Affect Long-Term Survival. Circulation Journal 81 (2): 213-219,2017.
Grandin EW, Wand A, Zamani P, Rame JE: Relation of Body Mass Index to Long-Term Survival After Cardiac Resynchronization Therapy. American Journal of Cardiology 118 (12): 1861-1867,2016.
Metkus TS, Mullin CJ, Grandin EW, Rame JE, Tampakakis E, Hsu S, Kolb TM, Damico R, Hassoun PM, Kass DA, Mathai SC: Heart Rate Dependence of the Pulmonary Resistance x Compliance (RC) Time and Impact on Right Ventricular Load. PloS One 11 (11): e0166463,2016.