Description of Research Expertise:
My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.
Hyman Matthew C, Schaller Robert D, Epstein Andrew E, Rame J Eduardo: Right Ventricular Pacing-Induced Hemodynamic Compromise in a Patient With a Left Ventricular Assist Device. Circulation. Arrhythmia and electrophysiology 9 (11): 2016.
Javaheri Ali, Molina Maria, Zamani Payman, Rodrigues Amrith, Novak Eric, Chambers Susan, Stutman Patricia, Maslanek Wilhelmina, Williams Mary, Lilly Scott M, Heeger Peter, Sayegh Mohamed H, Chandraker Anil, Briscoe David M, Daly Kevin P, Starling Randall, Ikle David, Christie Jason, Rame J Eduardo, Goldberg Lee R, Billheimer Jeffrey, Rader Daniel J: Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation : 2016.
Vallabhajosyula Prashanth, Kramer Matthew, Lazar Sofiane, McCarthy Fenton, Rame Eduardo, Wald Joyce, Szeto Wilson, Williams Matthew, Atluri Pavan, Desai Nimesh, Acker Michael: Lower-extremity complications with femoral extracorporeal life support. The Journal of thoracic and cardiovascular surgery 151 (6): 1738-44,2016.
Grandin E Wilson, Zamani Payman, Mazurek Jeremy A, Troutman Gregory S, Birati Edo Y, Vorovich Esther, Chirinos Julio A, Tedford Ryan J, Margulies Kenneth B, Atluri Pavan, Rame J Eduardo: Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation : 2016.
Prashanth Vallabhajosyula, MD, MS, Matthew Kramer, BS, Sofiane Lazar, BS, Fenton McCarthy, MD,Eduardo Rame, MD, Joyce Wald, MD, Wilson Szeto, MD, Matthew Williams, MD, Pavan Atluri, MD,
Nimesh Desai, MD, PhD, and Michael Acker, MD: Lower-extremity complications with femoral extracorporeal
life support The Journal of Thoracic and Cardiovascular Surgery : 2016.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE: Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation 133 (8): 706-16,2016.
Birati EY, Mathelier H, Molina M, Hanff TC, Mazurek JA, Atluri P, Acker MA, Rame JE, Margulies KB, Goldberg LR, Jessup M: Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions =35% Versus >35. The American Journal of Cardiology S0002-9149 (16): 30150-3,2016.
Burkhoff D, Maurer MS, Joseph S, Rogers JG, Birati Eo, Rame JE, Shah SJ: Reply: Is Pump the Answer to Heart Failure With Preserved Ejection Fraction? JACC Heart Fail 4 (1): 93,2016.
Rame JE: Metabolic Staging in Human Heart Failure: Circulating Acylcarnitines and the Failing Heart's Energetic Signature. J Am Coll cardiol 67 (3): 300-2,2016.
Stewart GC, Kittleson MM, Cowger JA, Johnson FL, Patel CB, Mountis MM, Patel PC, Rame JE, Testani J, Guglin ME, Teuteberg JJ, Stevenson LW: Who wants a left ventricular assist device for ambulatory heart failure? Early insights from the MEDAMACS screening pilot. J Heart Lung Transplant 34 (12): 1630-3,2015.