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J. Eduardo Rame, MD

J. Eduardo Rame, MD Physician

Medical Director, Ventricular Assist Device Program Assistant Professor of Medicine in Surgery Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Languages spoken:

  • Spanish

Dr. Rame is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Advanced Heart Failure and Transplant Cardiology, 2010

Clinical Expertise:

  • Heart Transplant - Post-Transplant Follow-Up
  • Heart Transplant Evaluation
  • Heart Transplantation
  • Hypertensive Heart Disease
  • Ischemic Heart Disease (Myocardial Ischemia)
  • Left-sided Heart Failure
  • Long Term Mechanical Circulatory Support
  • Right Sided Heart Failure
  • Temporary Mechanical Circulatory Support

Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard University
Residency: University of Texas Southwestern Medical Center
Fellowship: UT Southwestern Medical Center of Dallas
Fellowship: Johns Hopkins Hospital


American College of Cardiology, National American Heart Association, National American Institute of Biological Sciences, National Peer-Reviewed Medical Research Program for the US Army Medical Research and Material Command , National Heart Failure Society of America, National International Society for Heart and Lung Transplantation, International Massachusetts Medical Society, Local United Network for Organ Sharing (UNOS), National

Hospital Affiliation

Dr. Rame is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications:

Han JJ, Chen C, Chung J, Gaffey AC, Sotolongo A, Justice CM, Rame JE, Bermudez C, Acker MA: ECMO-Bridge to LVAD Therapy Is a Safe and Effective Strategy for Critically Ill Patients. The Journal of Heart and Lung Transplantation 36 (4): S328,2017.

Hanff TC, Mazurek JA, Grandin EW, Padegimas A, Howard J, Forde-McLean R, Wald J, Acker MA, Goldberg LR, Atluri P, Rame JE, Jessup M, Margulies KB: The Anemic Stress Index - A Novel Index that Predicts Short and Long Term Mortality of Patients on Continuous Flow Ventricular Assist Devices. The Journal of Heart and Lung Transplantation 36 (4): S173–S174,2017.

Padegimas A, Pak ES, Hanff TC, Mazurek JA, Seigerman ME, Menachem J, Marble J, Goldberg LR, Wald J, Atluri P, Rame JE: Peak Oxygen Consumption and VE/VCO2 Correlates with 6 Minutes' Walk Test in Patients Supported with Continuous Flow LVAD. The Journal of Heart and Lung Transplantation 36 (4): S436–S437,2017.

Grandin E, Mooney D, Kennedy DK, Kiernan MS, Kociol RD, Teuteberg JJ, Pagani FD, Gaffey AC, Atluri P, Birati E, Myers S, Naftel D, Oliveira G, Simpson KE, Yeh RW, Kirklin JK, Kormos RL: The Duration of Inotropic Support and Survival After Left Ventricular Assist Device. The Journal of Heart and Lung Transplantation 36 (4): S140–S141,2017.

Gentile JI, Molina, Atluri P, Rame JE, Wald JW, Birati EY, Goldberg LR, McLean R, Acker MI: ECMO Use in INTERMACS 1 Patients as a Bridge to LVAD with Intention to Transplant versus Bridge to Direct Heart Transplant. Single Center Experience. The Journal of Heart and Lung Transplantation 36 (4): S337,2017.

Chung JJ, Stetson R, Chen CW, Gaffey AC, Rame J, Acker MA: Doing the Math: The Costs of Long Term Mechanical Circulatory Support. The Journal of Heart and Lung Transplantation 36 (4): S287,2017.

Gentile JI, Atluri P, Desai ND, Vallabhajosyula p, Wald JW, Rame JE, Gutsche JT, Horak J, Acker MI: Outcomes of Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock in the Elderly. Large Single Center Experience. The Journal of Heart and Lung Transplantation 36 (4): S339,2017.

Han JJ, Sooppan R, Johnson AP, Chen CW, Gaffey AC, Phillips EC, Howard J, Rame JE, Acker MA: Higher Body Mass Index Increases Risk of HeartMate II Pump Thrombosis But Does Not Adversely Affect Long-Term Survival. Circulation Journal 81 (2): 213-219,2017.

Grandin EW, Wand A, Zamani P, Rame JE: Relation of Body Mass Index to Long-Term Survival After Cardiac Resynchronization Therapy. American Journal of Cardiology 118 (12): 1861-1867,2016.

Metkus TS, Mullin CJ, Grandin EW, Rame JE, Tampakakis E, Hsu S, Kolb TM, Damico R, Hassoun PM, Kass DA, Mathai SC: Heart Rate Dependence of the Pulmonary Resistance x Compliance (RC) Time and Impact on Right Ventricular Load. PloS One 11 (11): e0166463,2016.

Academic Contact Info

Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 615-7949
Patient appointments: 800-789-7366 (PENN)

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