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J. Eduardo Rame, MD

J. Eduardo Rame, MD Physician

Medical Director, Ventricular Assist Device Program Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Languages spoken:

  • Spanish

Dr. Rame is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Advanced Heart Failure and Transplant Cardiology, 2010

Clinical Expertise:

  • Heart Transplant - Post-Transplant Follow-Up
  • Heart Transplant Evaluation
  • Heart Transplantation
  • Hypertensive Heart Disease
  • Ischemic Heart Disease (Myocardial Ischemia)
  • Left-sided Heart Failure
  • Long Term Mechanical Circulatory Support
  • Right Sided Heart Failure
  • Temporary Mechanical Circulatory Support

Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard University
Residency: University of Texas Southwestern Medical Center
Fellowship: UT Southwestern Medical Center of Dallas
Fellowship: Johns Hopkins Hospital


American College of Cardiology, National American Heart Association, National American Institute of Biological Sciences, National Peer-Reviewed Medical Research Program for the US Army Medical Research and Material Command, National Heart Failure Society of America, National International Society for Heart and Lung Transplantation, International Massachusetts Medical Society, Local United Network for Organ Sharing (UNOS), National

Hospital Affiliation

Dr. Rame is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications:

Reza Nosheen, Chowns Jessica L, Merrill Shana L, Marzolf Amy, Zado Erica S, Palmer Matthew B, Deshpande Charuhas, Pryma Daniel A, Rame J Eduardo, Marchlinski Francis E, Owens Anjali Tiku: Frameshifts in Code and in Care: The Importance of Timely Genetic Evaluation. Circulation. Genomic and precision medicine 11 (5): e002215,2018.

Menachem Jonathan N, Birati Edo Y, Zamani Payman, Owens Anjali T, Atluri Pavan, Bermudez Christian A, Drajpuch David, Fuller Stephanie, Kim Yuli Y, Mascio Christopher E, Palanivel Vikram, Rame J Eduardo, Wald Joyce, Acker Michael A, Mazurek Jeremy A: Pulmonary hypertension: Barrier or just a bump in the road in transplanting adults with congenital heart disease. Congenital heart disease : 2018.

Birati Edo Y, Hanff Thomas C, Maldonado Dawn, Grandin E Wilson, Kennel Peter J, Mazurek Jeremy A, Vorovich Esther, Seigerman Matthew, Howard Jessica L L, Acker Michael A, Naka Yoshifumi, Wald Joyce, Goldberg Lee R, Jessup Mariell, Atluri Pavan, Margulies Kenneth B, Schulze P Christian, Rame J Eduardo: Predicting Long Term Outcome in Patients Treated With Continuous Flow Left Ventricular Assist Device: The Penn-Columbia Risk Score. Journal of the American Heart Association 7 (6): 2018.

Jason J. Han MD, Salman Zaheer MD, Rahul Kanade BA, Jennifer Chung MD, Carol W Chen MD, Ann C Gaffey MD, Christyna Justice RN, BSN, Alyse E Ameer BS, J. Eduardo Rame MD, Michael A. Acker MD, Pavan Atluri MD: Left Ventricular Assist Device Implantation Reduces Elevated Pulmonary Vascular Resistance in Patients Bridged to Heart Transplant Circulation Journal Epub ahead of Print : 2018.

Edo Y. Birati, MD, Thomas C. Hanff, MD, Dawn Maldonado, MD, E. Wilson, Grandin, MD, Peter J. Kennel, MD, Jeremy A. Mazurek, MD, Esther Vorovich, MD, Matthew Seigerman, MD, Jessica LL Howard, BS, Michael A. Acker, MD, Yoshifumi Naka, MD, Joyce Wald, DO, Lee R. Goldberg, MD MPH, Mariell Jessup, MD, Pavan Atluri, MD, Kenneth B. Margulies, MD, P. Christian Schulze, MD and J. Eduardo Rame, MD MPhil1: Predicting Long Term Outcome in patients treated with Continuous Flow Left Ventricular Assist Device - The Penn - Columbia Risk Score Journal of the American Heart Association Epub ahead of Print : 2018.

J.Eduardo Rame and Robert Kormos: Adverse Events and Mitigation Strategies, Mechanical Circulatory Support Braunwald's Mechanical Circulatory Support : 2018.

Gopal Dipika J, Hanff Thomas C, Mazurek Jeremy A, Grandin Wilson E, Howard Jessica, Forde-McLean Rhondalyn, Wald Joyce, King Kathie, Acker Michael A, Goldberg Lee R, Jessup Mariell, Atluri Pavan, Margulies Kenneth B, Rame Eduardo J, Birati Edo Y: Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure. The American journal of cardiology 120 (11): 2003-2007,2017.

Rene A Garvey, Desai Nimesh, Wald Joyce, Rame Jesus Eduardo, Frogel Jonathan K, Anwaruddin Saif: Transfemoral transcatheter aortic valve replacement with a self-expanding valve for severe aortic regurgitation in a patient with left ventricular assist device. Journal of cardiac surgery 32 (11): 741-745,2017.

Arabía Francisco A, Milano Carmelo A, Mahr Claudius, McGee Edwin C, Mokadam Nahush A, Rame J Eduardo, Moriguchi Jaime D, Ramzy Danny, Naftel David C, Myers Susan L, Kirklin James K: Biventricular Support With Intracorporeal, Continuous Flow, Centrifugal Ventricular Assist Devices. The Annals of thoracic surgery 105 (2): 548-555,2017.

Kiernan Michael S, Grandin E Wilson, Brinkley Marshall, Kapur Navin K, Pham Duc Thinh, Ruthazer Robin, Rame J Eduardo, Atluri Pavan, Birati Edo Y, Oliveira Guilherme H, Pagani Francis D, Kirklin James K, Naftel David, Kormos Robert L, Teuteberg Jeffrey J, DeNofrio David: Early Right Ventricular Assist Device Use in Patients Undergoing Continuous-Flow Left Ventricular Assist Device Implantation: Incidence and Risk Factors From the Interagency Registry for Mechanically Assisted Circulatory Support. Circulation. Heart failure 10 (10): 2017.

Academic Contact Info

Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 615-7949
Patient appointments: 800-789-7366 (PENN)

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