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J. Eduardo Rame, MD

J. Eduardo Rame, MD Physician

Medical Director, Ventricular Assist Device Program Assistant Professor of Medicine at the Hospital of the University of Pennsylvania Assistant Professor of Medicine in Surgery

Languages spoken:

  • Spanish

Dr. Rame is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Advanced Heart Failure and Transplant Cardiology, 2010

Clinical Expertise:

  • Heart Transplant - Post-Transplant Follow-Up
  • Heart Transplant Evaluation
  • Heart Transplantation
  • Hypertensive Heart Disease
  • Ischemic Heart Disease (Myocardial Ischemia)
  • Left-sided Heart Failure
  • Long Term Mechanical Circulatory Support
  • Right Sided Heart Failure
  • Temporary Mechanical Circulatory Support

Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: University of Texas Southwestern Medical Center
Fellowship: UT Southwestern Medical Center of Dallas
Fellowship: Johns Hopkins Hospital


American College of Cardiology, National American Heart Association, National American Institute of Biological Sciences, National Peer-Reviewed Medical Research Program for the US Army Medical Research and Material Command , National Heart Failure Society of America, National International Society for Heart and Lung Transplantation, International Massachusetts Medical Society, Local United Network for Organ Sharing (UNOS), National

Hospital Affiliation

Dr. Rame is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications:

Han Jason J, Sooppan Renganaden, Johnson Adam P, Chen Carol W, Gaffey Ann C, Phillips Emily C, Howard Jessica, Rame J Eduardo, Acker Michael A, Atluri Pavan: Higher Body Mass Index Increases Risk of HeartMate II Pump Thrombosis But Does Not Adversely Affect Long-Term Survival. Circulation journal : official journal of the Japanese Circulation Society 81 (2): 213-219,2017.

Grandin E Wilson, Wand Alison, Zamani Payman, Rame J Eduardo, Verdino Ralph J: Relation of Body Mass Index to Long-Term Survival After Cardiac Resynchronization Therapy. The American journal of cardiology 118 (12): 1861-1867,2016.

Hyman Matthew C, Schaller Robert D, Epstein Andrew E, Rame J Eduardo: Right Ventricular Pacing-Induced Hemodynamic Compromise in a Patient With a Left Ventricular Assist Device. Circulation. Arrhythmia and electrophysiology 9 (11): 2016.

Stewart Garrick C, Kittleson Michelle M, Patel Parag C, Cowger Jennifer A, Patel Chetan B, Mountis Maria M, Johnson Frances L, Guglin Maya E, Rame J Eduardo, Teuteberg Jeffrey J, Stevenson Lynne W: INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure. Circulation. Heart failure 9 (11): 2016.

J. Eduardo Rame, Emma Birks: Metabolic Reprogramming After Left Ventricular Assist Device: Remodeling Without Recovery of Cardiac Energetics∗ Journal of the American College of Cardiology: Basic To Translational Science 6 (1): 445-448,2016.

Javaheri Ali, Molina Maria, Zamani Payman, Rodrigues Amrith, Novak Eric, Chambers Susan, Stutman Patricia, Maslanek Wilhelmina, Williams Mary, Lilly Scott M, Heeger Peter, Sayegh Mohamed H, Chandraker Anil, Briscoe David M, Daly Kevin P, Starling Randall, Ikle David, Christie Jason, Rame J Eduardo, Goldberg Lee R, Billheimer Jeffrey, Rader Daniel J: Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 35 (11): 1295-1302,2016.

Vallabhajosyula Prashanth, Kramer Matthew, Lazar Sofiane, McCarthy Fenton, Rame Eduardo, Wald Joyce, Szeto Wilson, Williams Matthew, Atluri Pavan, Desai Nimesh, Acker Michael: Lower-extremity complications with femoral extracorporeal life support. The Journal of thoracic and cardiovascular surgery 151 (6): 1738-44,2016.

Grandin E Wilson, Zamani Payman, Mazurek Jeremy A, Troutman Gregory S, Birati Edo Y, Vorovich Esther, Chirinos Julio A, Tedford Ryan J, Margulies Kenneth B, Atluri Pavan, Rame J Eduardo: Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 36 (1): 97-105,2016.

Prashanth Vallabhajosyula, MD, MS, Matthew Kramer, BS, Sofiane Lazar, BS, Fenton McCarthy, MD,Eduardo Rame, MD, Joyce Wald, MD, Wilson Szeto, MD, Matthew Williams, MD, Pavan Atluri, MD, Nimesh Desai, MD, PhD, and Michael Acker, MD: Lower-extremity complications with femoral extracorporeal life support The Journal of Thoracic and Cardiovascular Surgery : 2016.

Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE: Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation 133 (8): 706-16,2016.

Academic Contact Info

Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: 215-615-7949
Fax: 215-349-5603
Patient appointments: 800-789-7366 (PENN)

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