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Ian Frank, MD

Ian Frank, MD Physician

Director, Anti-Retroviral Clinical Research
Director, Clinical Core, Penn Center for AIDS Research
Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Frank is a Penn Medicine employed physician.

About Dr. Ian Frank

Recognized in Philadelphia Magazine's annual Top Docs issue, 2004 - 2012, and 2014 - 2016

Recognized by America's Top Doctors, 2007, 2008, 2010, 2014

Recognized by Best Doctors in America 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Infectious Diseases

Programs & Centers:

Board Certification:

  • Infectious Disease, 1992
  • Internal Medicine, 1983

Clinical Expertise:

  • HIV and AIDS
  • Lesbian, Gay, Bisexual and Transgender Health (LGBT)

Description of Clinical Expertise

HIV and AIDS, Lesbian, Gay, Bisexual and Transgender Health (LGBT)

Practice Locations and Appointments

  • Infectious Diseases

    Perelman Center for Advanced Medicine South Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Dartmouth Medical School
Residency: Saint Joseph's Medical Center
Residency: Graduate Hospital
Fellowship: Hospital of the University of Pennsylvania


Adult AIDS Clinical Trials Group, National American Association for the Advancement of Science, National American Society of Microbiology, National HIV Vaccine Trials Network, International Infectious Diseases Society of America, International International AIDS Society, International National Institute of Allergy and Infectious Diseases Investigator Initiated Program Project Review Committee, ZAI1 JBS-A, National National Institute of Allergy and Infectious Diseases, Centers for AIDS Research and Developmental Center for AIDS Research Meeting, ZAI1 JRR-A (J3) study section, National

Hospital Affiliation

Dr. Frank is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Beck JM, Schloss PD, Venkataraman A, Twigg IH, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB, Lung HIV Microbiome Project: Multi-center Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals American journal of respiratory and critical care medicine 192 (11): 1335-44,2015.

Fuchs JD, Frank I, Elizaga ML, Allen M, Frahm N, Kochar N, Li S, Edupuganti S, Kalams SA, Tomaras GD, Sheets R, Pensiero M, Tremblay MA, Higgins TJ, Latham T, Egan MA, Clarke DaK, Eldridge JH, HVTN 090 Study Group and the National Institutes of Allergy and Infectious Diseases HIV Vaccine Trials Network, Mulligan M, Rouphael N, Estep S, Rybczyk K, Dunbar D, Buchbinder S, Wagner T, Isbell R, Chinnell V, Bae J, Escamilla G, Tseng J, Fair R, Ramirez S, Broder G, Briesemeister L, Ferrara A: First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Vesicular Stomatitis Virus Human Immunodeficiency Virus-1 gag Vaccine (HVTN 090) Open forum infectious diseases 2 (3): ofv082,2015.

Koblin BA, Grant S, Frye V, Superak H, Sanchez B, Lucy D, Dunbar D, Graham P, Madenwald T, Escamilia G, Swann E, Morgan C, Novak RM, Frank I: HIV Sexual Risk and Syndemics among Women in Three Urban Areas in the United States: Analysis from HVTN 906 Journal of urban health : bulletin of the New York Academy of Medicine 92 (3): 572-83,2015.

Eberhart MG, Yehia BR, Hillier A, Voytek CD, Fiore DJ, Blank M, Frank I, Metzger DS, Brady KA: Individual and community factors associated with geographic clusters of poor HIV care retention and poor viral suppression Journal of acquired immune deficiency syndromes (1999) 69 Suppl 1 : S37-43,2015.

Overton ET, Stapleton J, Frank I, Hassler S, Goepfert PA, Barker D, Wagner E, von Krempelhuber A, Virgin G, Meyer TP, Müller J, Bädeker N, Grünert R, Young P, Rösch S, Maclennan J, Arndtz-Wiedemann N, Chaplin P: Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial Open forum infectious diseases 2 (2): ofv040,2015.

Hay CM, Wilson GJ, Elizaga M, Li S, Kochar N, Allen M, Sobieszczyk M, Frank I, Frahm N, Tomaras GD, Egan M, Pensiero M, Eldridge J: An HIV DNA Vaccine Delivered by Electroporation and Boosted by rVSV HIV-1 Gag Is Safe and Immunogenic in Healthy HIV-uninfected Adults AIDS research and human retroviruses 30 Suppl 1 : A17,2014.

Fishman J, Taylor L, Kooker P, Frank I: Parent and adolescent knowledge of HPV and subsequent vaccination Pediatrics 134 (4): e1049-56,2014.

Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing Genome biology 15 (10): 487,2014.

Ramirez Lorenzo A, Daniel Alexander, Frank Ian, Tebas Pablo, Boyer Jean D: Seroprotection of HIV-infected subjects after influenza A(H1N1) vaccination is directly associated with baseline frequency of naive T cells The Journal of infectious diseases 210 (4): 646-50,2014.

Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, Spratt SK, Surosky RT, Giedlin MA, Nichol G, Holmes MC, Gregory PD, Ando DG, Kalos M, Collman RG, Binder-Scholl G, Plesa G, Hwang WT, Levine BL, June CH: Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV The New England journal of medicine 370 (10): 901-10,2014.

Academic Contact Info

502 Johnson Pavilion
3610 Hamilton Walk 6073

Philadelphia, PA 19104-6073
Phone: (215) 662-7419
Fax: (215) 349-8011
Patient appointments: 800-789-PENN (7366)

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