Hsiaoju (Sharon) Lee, PhD
Penn Medicine Provider

About me

  • Research Assistant Professor of Radiology

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My research

Young AJ, Doot RK, Cho JK, Pham JM, Ordonez AA, Del Castillo AF, Dominguez TL, Dugyala S, Schubert EK, Lee H, Pantel AR, Mach RH, Mankoff DA, Sellmyer MA. First-in-Human Biodistribution and Dosimetry of [(11)C]Trimethoprim , Mol Imaging Biol, 28(1): 2026,60-67


Hwan Lee, Swarbhanu Sarkar, Kexiang Xu, Paul Martorano, Jonathan Pham, Peter Sang Uk Park, A Paden King, Hsiaoju S Lee, David A Mankoff, Daniel A Pryma, Mark A Sellmyer Influence of Subcellular Localization on the Cytotoxicity of Targeted α-Therapy , J Nucl Med, 67(3): 2026,429-437


Siran Qian, Surendra Reddy Gundam, Carol Garcia, Shihong Li, Hsiaoju Lee, Jay S Wright C-H (radio)fluorination of hydroxamides via strained and electronically tunable α-lactams enabled by N-O scission , Nucl Med Biol., 152-153: 2026,109594


Scott PJH, VanBrocklin HF, Cumming RC, Dick DW, Ignace C, Bunning S, Cutler CS, Lee H, Schwarz SW, Zigler SS. FDA Investigator Training for PET Drug Manufacturing Inspections , J Nucl Med: 2025,jnumed.125.271221


Chia-Ju Hsieh; Dinahlee Saturnino Guarino; Anthony J. Young; Andrew D. Siderowf; Ilya Nasrallah; Alexander Schmitz; Carol Garcia; Ho Young Kim; Erin K. Schubert; Hsiaoju Lee; Joel S. Perlmutter; Robert H. Mach Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer , Cells, 14(15): 2025,1157


Bunning S, Christodoulou D, Cohen JE, Cutler CS, Dick DW, Ghosh K, Ignace C, Kasliwal RK, Lee H, Marzella L, Pohlhaus T, Scott PJH, Schwarz SW, Syed IA, VanBrocklin HF, Wasil LR, Zigler SS. Proceedings: PET Drugs-A 2023 Workshop on Product Quality, Regulatory Submissions, Facility Inspections, and Benefit-Risk Considerations , J Nucl Med, 66(9): 2025,1480-1492


Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, Kranzler HR. [(11)C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study , J Nucl Med, 66: 2025,1112-1118


Hasan Babazada, Paul Martorano, Hsiaoju Lee, Shuyao Geng, Vandana Batra, John M Maris, Daniel A Pryma, Sarah B Gitto, Michael D Farwell PARP1-targeted alpha therapy enhances target expression , EJNMMI, 15: 2025,63


Tian GL, Hsieh CJ, Guarino DS, Graham TJA, Lengyel-Zhand Z, Schmitz A, Chia WK, Young AJ, Crosby JG, Plakas K, Huang T, Jiang H, Yu Y, Hou C, Lee H, Petersson EJ, Giannakoulias S, O'Shea J, Kotzbauer P, Tu Z, Mathis CA, Mach RH. The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease , RSC Med Chem: 2025


Plakas K, Hsieh CJ, Saturnino Guarino D, Hou C, Chia WK, Young A, Schmitz A, Ho YP, Weng CC, Lee H, Li S, Graham TJA, Mach RH. Toward a Small-Molecule Antagonist Radioligand for Positron Emission Tomography Imaging of the Mu Opioid Receptor , ACS Chem Neurosci, 16(8): 2025,1592-1603