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Horace M. DeLisser, MD

Horace M. DeLisser, MD Physician

Associate Professor of Medicine

Dr. DeLisser is employed by Penn Medicine.

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Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 1991
  • Internal Medicine, 1988
  • Pulmonary Disease, 1990

Clinical Expertise:

  • Critical Care Medicine
  • Lung Disease
  • Medical Ethics

Practice Locations and Appointments

  • Harron Lung Center

    Perelman Center for Advanced Medicine West Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Cancer Society, Cell Structure and Metastasis Peer Review Committee, National American College of Physicians, National American Heart Association, Mid-Atlantic Peer Review Study Group, National American Heart Association, Southeastern Pennsylvania Peer Review Committee, Local American Physiological Society , National American Society for Investigative Pathology , National American Thoracic Society , National Association for Academic Minority Physicians, National College of Physicians of Philadelphia , Local Laennec Society , Local Medical Society of Eastern Pennsylvania , Local NHLBI Workshop on Recruitment and Retention of African Americans, Hispanic Americans, and Native Americans in Scientific Research Careers Relevant to Heart, Lung, Blood, and Sleep Disorders , National NIH Lung Injury Repair and Remodeling Study Section, National NIH Minority/Disability Fellowship (FIO) Study Selection, National NIH Pathology A Study Section, National

Hospital Affiliation

Dr. DeLisser is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests
-Endothelial Cell Adhesion and Motility
-Leukocyte-endothelial Interactions
-Lung Injury and Repair

Description of Research
The lumen of all blood vessels are lined by a single layer of cells, known as endothelial cells, that regulate the movement of fluids, solutes and leukocytes across the vessel wall and out of the circulation. My laboratory focuses broadly on these cells and the adhesive interactions of the endothelial cells with each other, with leukocytes and with the extracellular matrix. These endothelial cell adhesion interactions are critical to formation of blood vessels (angiogenesis) and the recruitment of leukocytes to sites of infection and injury (inflammation), processes that are essential to repair and restoration of damaged tissue. Consequently, understanding these processes may provide new insights for the treatment of destructive and/or fibrotic lung diseases. Active projects include:

PECAM-1 and Angiogenesis: Current studies in my laboratory investigate the intracellular signaling cascades, triggered by PECAM-1, that promote endothelial cell motility and thus angiogenesis.

Angiogenesis and Post-natal Lung Development: Ongoing studies explore the role that the endothelium and molecules such as PECAM-1 might play in the post-natal formation and maturation of alveoli.

Hyaluronan Receptors (CD44 and RHAMM) In Angiogenesis: Studies are underway to fully define the activities of these molecules in mediating various functions of endothelial cells.

HA Receptors and Lung Inflammation: Ongoing collaborations with the laboratory of Dr. Rashmin Savani explore the various roles of HA receptors in lung inflammation and injury.

Rotation Projects
1. The involvement of PECAM-1 in endothelial cell motility and angiogenesis
2. The role of the vasculature in post-natal lung development
3. The role of CD44 in angiogenesis

Lab personnel:
Gaoyuan Cao, M.D. – Senior Investigator
Melane Fehrenbach, B.S. – Research Specialist and Lab Manager
Jeffery Finklestein, B.S., - Graduate Student
Jing-Xu Zhu, M.D., Ph.D. – Postdoctoral Fellow

Academic Contact Info

Room 644
6th Floor, South Pavilion, Perelman Center for Advanced Medicine
3400 Civic Center Blvd

Philadelphia, PA 19104-5162
Phone: (215) 898-4409
Patient appointments: 800-789-7366 (PENN)

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