Description of Research Expertise:
Dr. Song is a biomedical engineer with a strong background in MRI physics and expertise in various areas of MRI engineering. Dr. Song has extensive experience in developing novel dynamic imaging strategies in MRI. For over a decade, his research has focused on the development of dynamic contrast-enhanced (DCE-) MRI strategies based on novel radial data acquisition and reconstruction methods that allow ultra-rapid dynamic imaging at both high spatial and high temporal resolutions. Utilizing the golden angle radial acquisition strategy, Dr. Song also developed and implemented effective strategies to retrospectively compensate for respiratory motion in DCE-MRI. The technique also permits the reconstruction of the dynamic series to be highly flexible, allowing many of the decisions regarding spatial/temporal resolution to be made retrospectively and optimally. These strategies are currently being utilized for the assessment of treatment effects in various tumors, including lung, liver, breast, kidney and ovarian/fallopian tube. The methods he has developed have also been utilized in other areas of research, including rapid non-contrast enhanced dynamic MRA and fast tissue T1 mapping. Dr. Song collaborates with clinicians in various departments within Penn’s School of Medicine and other institutions, including the Departments of Medicine, Obstetrics and Gynecology, Neurology, and Radiation Oncology. The scope of training under Dr. Song’s guidance includes understanding the various tumor perfusion models, MRI physics, MRI pulse sequence programming and image post-processing.
Ziwu Zhou, Fei Han, Songlin Yu, Dandan Yu, Stanislas Rapacchi, Hee Kwon Song, Danny JJ Wang, Peng Hu, Lirong Yan: Accelerated non-contrast enhanced 4-dimensional intracranial MR angiography using golden-angle stack-of-stars trajectory and compressed sensing with magnitude subtraction Magnetic Resonance in Medicine 79 (2): 867-878,2018.
Wen Cao, Yulin V Chang, Erin K Englund, Hee Kwon Song, Suliman Barhoum, Zachary B Rodgers, Michael C Langham, Felix W Wehrli: High-Speed Whole-Brain Oximetry Via Golden-Angle Radial MRI Magnetic Resonance in Medicine 79 (1): 217-223,2018.
F. Cong, Y. Zhuo, S. Yu, X. Zhang, X. Miao, J. An, H. K. Song, D. J. J. Wang, L. Yan: Non-contrast Enhanced Time-Resolved 4-Dimensional Dynamic Intracranial MR Angiography at 7T: A Feasibility Study Journal of Magnetic Resonance Imaging 48 (1): 111-120,2018.
Xia Zhao, Hee Kwon Song, Felix W Wehrli: In vivo bone 31P relaxation times and their implications on mineral quantification Magnetic Resonance in Medicine : 2018.
Xia Zhao, Hee Kwon Song, Alan C. Seifert, Cheng Li, Felix W. Wehrli: Feasibility of Assessing Bone Matrix and Mineral Properties In Vivo by Combined Solid-State 1H
3 and 31P MRI PLOS ONE 12 (3): e0173995,2017.
Zhang Ning, Magland Jeremy F, Song Hee Kwon, Wehrli Felix W: Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI. Journal of magnetic resonance imaging : JMRI 41 (4): 954-63,2015.
Wang Ping, Xue Yiqun, Zhao Xia, Yu Jiangsheng, Rosen Mark, Song Hee Kwon: Effects of flip angle uncertainty and noise on the accuracy of DCE-MRI metrics: comparison between standard concentration-based and signal difference methods. Magnetic Resonance Imaging 33 (1): 166-73,2015.
Song Hee Kwon, Yan Lirong, Smith Robert X, Xue Yiqun, Rapacchi Stanislas, Srinivasan Subashini, Ennis Daniel B, Hu Peng, Pouratian Nader, Wang Danny J J: Noncontrast enhanced four-dimensional dynamic MRA with golden angle radial acquisition and K-space weighted image contrast (KWIC) reconstruction. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 72 (6): 1541-51,2014.
Ciunci Christine A, Perini Rodolfo F, Avadhani Anjali N, Kang Hyunseon C, Sun Weijing, Redlinger Maryann, Harlacker Kathleen, Flaherty Keith T, Giantonio Bruce J, Rosen Mark A, Divgi Chaitanya R, Song Hee Kwon, Englander Sarah, Troxel Andrea, Schnall Mitchell, O'Dwyer Peter J: Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer. Cancer 120 (1): 77-85,2014.
Li Cheng, Magland Jeremy F, Rad Hamidreza Saligheh, Song Hee Kwon, Wehrli Felix W: Comparison of optimized soft-tissue suppression schemes for ultrashort echo time MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 68 (3): 680-9,2012.