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He Nucleus Xu, PhD

He Nucleus Xu, PhD Researcher

Research Assistant Professor of Radiology

Dr. Xu is employed by Penn Medicine.

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Clinical Specialties

Programs & Centers:


Abramson Cancer Center of the University of Pennsylvania, National International Society on Oxygen Transport to Tissue (ISOTT), International The Institute for Translational Medicine and Therapeutics (ITMAT), National The Institute on Aging, University of Pennsylvania, Local the Society of Photo-Optical Instrumentation Engineers (SPIE), International

Hospital Affiliation

Dr. Xu is employed by Penn Medicine.


Description of Research Expertise:

Optical imaging of endogenous and/or exogenous fluorescence for the following research interests:
1) Identification of optical redox imaging biomarkers for cancer diagnosis/prognosis (cell culture, tissue, frozen clinical biopsy samples);
2) Identification of optical redox imaging biomarkers for aging and age-associated neurodegenerative diseases (cell culture, tissue, clinical biopsy samples);
3) Development of optical redox imaging methods for detecting therapeutic effects (cell culture & tissue);
4) Development of label-free optical imaging methods to quantify NADH and FAD signals in formalin-fixed-paraffin-embedded tissue slides;

Selected Publications:

He N. Xu*, Huaqing Zhao, Karthikeyani Chellappa, James G. Davis, Shoko Nioka, Joseph A. Baur, Lin Z. Li*: Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information Mol Imaging Biol in press : 2019.

Yu Wen, He N. Xu, Lisa Privette Vinnedge, Min Feng, Lin Z. Li: Optical Redox Imaging Detects the Effects of DEK Oncogene Knockdown on the Redox State of MDA-MB-231 Breast Cancer Cells Mol Imaging Biol in press : 2019.

He N. Xu*, Min Feng, Kavindra Nath, David Nelson, Jeff Roman, Huaqing Zhao, Zhenwu Lin, Jerry Glickson, Lin Z. Li*: Optical redox imaging of lonidamine treatment response of melanoma cells and xenografts Mol Imaging Biol : 2018.

Xu, He N.*, Tchou, Julia., Feng, Min, Zhao, Huaqing, Li, Lin Z*.: Optical redox imaging indices discriminate human breast cancer from normal tissues J Biomed Opt 21 : 114003,2016.

Xu, H. N.*, Li, L. Z.: Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity J Innov Opt Health Sci 7 (2): 1430002-1-20,2014.

Xu, He N., Nioka, Shoko, Glickson, Jerry D., Chance, Britton, Li, Lin Z.: Quantitative mitochondrial redox imaging of breast cancer metastatic potential J Biomed Opt 15 (3): 036010,2010.

Li, L. Z., Zhou, R., Xu, H. N., Moon, L., Zhong, T., Kim, E. J., Qiao, H., Reddy, R., Leeper, D., Chance, B., Glickson, J. D.: Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential Proc Natl Acad Sci USA 106 (16): 6608-13,2009.

Zhenwu Lin*, He N. Xu*, Yunhua Wang, Joanna Floros, Lin Z. Li: Differential expression of PGC1α in intratumor redox subpopulations of breast cancer Adv Exp Med Biol 1072 : 2018.

Sun, Nannan, Xu, He N., Luo, Qingming, Li, Lin Z.: Potential indexing of the invasiveness of breast cancer cells by mitochondrial redox ratios Adv Exp Med Biol 923 : 121-127,2016.

Xu, H. N., Zheng, G., Tchou, J., Nioka, S., Li, L. Z.: Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging SpringerPlus 2 (1): 73,2013.

Xu, H. N., Nioka, S., Li, L. Z.: Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model Biomarker Research 1 : 6,2013.

Xu, He N., Feng, Min, Moon, Lily, Dolloff, Nathan, El-Deiry, Wafik, Li, Lin Z.: Redox imaging of the p53-dependent mitochondrial redox state in colon cancer ex vivo J Innov Opt Health Sci 06 : 1350016,2013.

Xu, H. N., Zhao, H., Mir, T. A., Lee, S. C., Feng, M., Choe, R., Glickson, J. D., Li, L. Z.: CHOP therapy induced mitochondrial redox state alteration in non-hodgkin's lymphoma xenografts J Innov Opt Health Sci 6 : 1350011,2013.

Xu, He N., Kadlececk, Stephen, Profka, Harrilla, Glickson, Jerry. D., Rizi, Rahim, Li, Lin Z.: Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized 13C-pyruvate Acad Radiol 21 (2): 223-231,2014.

Cai, Kejia, Xu, He N., Singh, Anup, Moon, Lily, Haris, Mohammad, Reddy, Ravinder, Li, Lin Z.: Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI Mol Imaging Biol 16 (5): 670-9,2014.

Academic Contact Info

B6 Blockley Hall, 423 Guardian Drive
& Rm 171 John Morgan Bldg, 3700 Hamilton Walk

Philadelphia, PA 19104
Phone: (215) 746-7386