Hayley M. Knollman, MD
Medical Oncology
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center
Penn Medicine Provider

About me

  • Physician Leader, Oncology Clinical Effectiveness Team
  • Assistant Professor of Clinical Medicine (Hematology-Oncology)

Education and training

  • Medical School: Indiana University Hospital
  • Residency: Barnes-Jewish Center for Outpatient Health
  • Fellowship: Temple University Hospital

What my patients think about me

Average Rating

786 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

January 2026
trust her
December 2025
so grateful god allowed me to be placed under her care.
December 2025
dr knollman is very professional and caring - conscientious, too. i had an appointment at 7:30 and then one at 8 and and had to wait to 10:45 to see her.
December 2025
wonderful holistic oncologist and definitely recommend

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Knollman is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Jung W, Hubbard RA, Smith AM, Ko K, Huang A, Wang J, Isaacs JM, Zhang L, Liu PP, Chen Z, Shah PD, Mintzer D, Bhattacharya S, Knollman HM, Clark AS, Koropeckyj-Cox D, Messinger M, Wilcox NS, Xia C, Narayan V, Upshaw JN, Armenian SH, Ky B. Risk-guided cardioprotection with carvedilol in patients with breast cancer (CCT guide): a phase 1 randomized clinical trial , Breast Cancer Res Treat, 211(2): 2025,293-305


Emily Xu, James M Schuster, Anish Butala, Gabrielle W Peters, Alvand Hassankhani, Hayley M Knollman, Colbey W Freeman, Neil R Malhotra. Disparities in patient enrollment of spinal oncology clinical trials. , Neurooncol Pract , 12(5): 2025,892-900


Berlin E, Ko K, Ma L, Messing I, Hollawell C, Smith AM, Taunk NK, Narayan V, Upshaw JN, Clark AS, Shah PD, Knollman H, Bhattacharya S, Koropeckyj-Cox D, Wang J, Yegya-Raman N, Han IS, Lefebvre B, Li T, Wilcox NS, Jung W, Chen J, Freedman GM, Ky B. Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy , JACC CardioOncol, 7(3): 2025,219-230


Emily Xu, Ritesh Karsalia, Ellie Gabriel, Alan Napole, Claudia Hejazi-Garcia, Jason Kost, Scott D McClintock, James M Schuster, Anish Butala, Gabrielle W Peters, Alvand Hassankhani, Hayley M Knollman, Colbey W Freeman, Neil R Malhotra. Preoperative prediction of postoperative needs after spinal tumor surgery. , Clin Neurol Neurosurg, 250: 2025,108752.


Julia Tchou, Amy Clark, Neil Taunk, Gary Freedman, Nucleus Xu, Andy Minn, Angela Bradbury, Angela Demichele Gross, Susan Domchek, Hayley Knollman, Rachel Jankowitz, Payal Shah, Oluwadamilola Fayanju, Anupma Nayak, Joseph Fraietta and Alexander Huang Major pathologic response after a single radiotherapy fraction + a single pembrolizumab dose given preoperatively in patients with cT1N0 triple negative breast cancer (TNBC) – preliminary results of a phase 1b/2 study (NCT04454528) , Journal for ImmunoTherapy of Cancer, Society for Immunotherapy of Cancer, Denver, CO, 10: 2023,A674-A674


Alexandra Torres; Carey Kokkonen; Mary Oladeji; Kurt D'Andrea; Rosemarie Mick; Vivek Narayan; Michael Mallamaci; Gayle Ewing; Hayley Knollman; Nadine M. Tung; Mark Robson; Katherine L. Nathanson; Susan Domchek; Payal D. Shah Harnessing olaparib, palbociclib, and endocrine therapy (HOPE): Phase I/II trial of olaparib, palbociclib and fulvestrant in patients with BRCA1/2-associated, hormone receptor-positive, HER2-negative metastatic breast cancer , San Antonio Breast Cancer Symposium, San Antonio, TX., 82: 2022


Lauren Bayne; Isoris Nivar; Brooke Goodspeed; Shannon Deluca; E. Paul Wileyto; Natalie Shih; Anupma Nayak; Michael D Feldman; Joshua Edwards; Kevin Fox; Jennifer M. Matro; Susan Domchek; Hayley Knollman; Rachel Jankowitz; Angela Bradbury; Payal D. Shah; Jewell Graves; George Woodfield; Elizabeth Chislock; Jianping Wang; George Belka; Lewis A. Chodosh; Amy S. Clark; Angela DeMichele Identifying breast cancer survivors with dormant disseminated tumor cells: The PENN-SURMOUNT screening study , Cancer Research, San Antonio Breast Cancer Symposium, San Antonio, TX. , 81: 2021


Igor Makhlin; Amy S Clark; Paul Wileyto; Noah Goodman; John Ndicu; Shannon DeLuca; Candace Clark; S. William Stavropoulos; Natalie Shih; Michael D Feldman; Susan M Domchek; Jennifer M Matro; Payal D Shah; Hayley M Knollman; Kevin R Fox; Kara N Maxwell; Lewis A Chodosh; Angela DeMichele Investigating the clinical utility of tumor mutational burden in predicting rapid progression and death in patients with metastatic breast cancer , Cancer Research/San Antonio Breast Cancer Symposium, San Antonio, TX., 81: 2021


Biniyam G.Demissei, Srinath Adusumalli, Rebecca A.Hubbard, Srinivas Denduluri, Vivek Narayan, Amy S. Clark, Payal Shah, Hayley Knollman, Kelly D. Getz, Richard Aplenc, Joseph R. Carver, Bonnie Ky Cardiology Involvement in Patients With Breast Cancer Treated With Trastuzumab , JACC CardioOncology, 2(2): 2020,179-189


Biniyam G. Demissei, Rebecca A. Hubbard, Liyong Zhang, Amanda M. Smith, Karyn Sheline, Caitlin McDonald, Vivek Narayan, Susan M. Domchek, Angela DeMichele, Payal Shah, Amy S. Clark, Kevin Fox, Jennifer Matro, Angela R. Bradbury, Hayley Knollman, Kelly D. Getz, Saro H. Armenian, James L. Januzzi, W. H. Wilson Tang, Peter Liu, and Bonnie Ky Changes in Cardiovascular Biomarkers with Breast Cancer Therapy and Associations with Cardiac Dysfunction , Journal of the American Heart Association, 9(2): 2020,e014708.