Description of Research Expertise

Basic science: Role of intracellular calcium dysregulation on neuronal apoptosis and neurodegeneration, autophagy, synapse, cognitive dysfunction, depression and anxiety psychiatric disorders, in neurodegenerative diseases, especially in Alzheimer's Disease, stroke, and amyotrophic lateral sclerosis. Treatment of Alzheimer's disease. Mechanisms of anesthesia mediated dual effects of neuroprotection and neurotoxicity, especially in the developing brains and in Alzheimer's disease.

Clinical science: Clinical use of Supraglottic Jet Oxygenation and Ventilation (SJOV) to maintain oxygenation/ventilation in patients with respiratory depression or apnea, especially during difficult airway management, emergent airway management rescue.

Selected Publications

Yang M, Li H, Zhou Y, Wei H, Cheng Q.: Type and morphology affect the success rate of bronchoscopy for postintubation tracheal stenosis Laryngoscope Investig Otolaryngol 9 : e70002,2024.

Xu R, Li Z, Jiang X, Zhang W, Xu Y, Zhang Y, Zhu L, Wei H, Shi H, Wang X.: Effect of supraglottic jet oxygenation and ventilation on hypoxemia in patients undergoing endoscopic surgery with sedation: A meta-analysis of randomized controlled trials J Clin Anesth 97 : 111559,2024.

Yang M, Li H, Zhou Y, Li H, Wei H, Cheng Q.: Airway collapse hinders recovery in bronchoscopy therapy for postintubation tracheal stenosis patients Eur Arch Otorhinolaryngol : 2024.

Zhang W, Zhao X, Bhuiyan P, Liu H, Wei H.: Neuroprotective effects of dantrolene in neurodegenerative disease: Role of inhibition of pathological inflammation J Anesth Transl Med : 2024.

Vera R, Hong N, Jiang B, Liang G, Eckenhoff MF, Kincaid HJ, Browne V, Chellaraj V, Gisewhite D, Greenberg M, Ranjan S, Zhu G, Wei H.: Effects of Intranasal Dantrolene Nanoparticles on Brain Concentration and Behavior in PS19 Tau Transgenic Mice J Alzheimers Dis : 2024.

Ping Xie, Zhiyun Wu, Benjun Zha1, Li Xu, Shanyi Shen, Haibin Zhuang, Huafeng Wei: Risk factors for pharyngalgia and xerostomia undergoing supraglottic jet oxygenation and ventilation in gastrointestinal endoscopy: A retrospective study Scientific Report : 2023.

Mingyuan Yang, Yunzhi Zhou, Hong Li, Huafeng Wei, Qinghao Cheng: Lung isolation—a personalized and clinically adapted approach to control bronchoscopy-associated acute massive airway hemorrhage BMC Pulmonary Medicine 23 : 1-9,2023.

Yang M, Wei H, Hou Q, Wang B, Cheng Q: Evaluation of Supraglottic Jet Oxygenation and Ventilation in 105 Patients During Bronchoscopy Using the Twinstream® Microprocessor-Controlled Jet Ventilator and the Wei Nasal Jet® Tube Medical Science Monitor 29 : e938602,2023.

Juan Wei, Xiaowei Zhang, Keting Min, Huanping Zhou, Xuan Shi, Huimin Deng, Wei Mo, Huafeng Wei, Yang Gu, Xin Lv: Supraglottic Jet Oxygenation and Ventilation to Minimize Hypoxia in Patients Receiving Flexible Bronchoscopy Under Deep Sedation: A 3-Arm Randomized Controlled Trial Anesthesia and Analgesia : 2023.

Jiang, B, Shi Y, Abou MB, Xu L, Liang G, Wei H.: Effects of chronic intranasal dantrolene on nasal mucosa morphology in mice European Review for Medical and Pharmacological Sciences 26 : 198-203,2022.

View all publications

Academic Contact Information

Department of Anesthesiology and Critical Care Medicine
University of Pennsylvania
305 John Morgan Building
3620 Hamilton Walk
Email: huafeng.wei@pennmedicine.upenn.edu
Philadelphia, PA 19104-6112
Phone: 215-260-9840