Description of Research Expertise:
Basic science: Role of intracellular calcium dysregulation on neuronal apoptosis, autophagy and neurodegenration in neurodegenerative diseases, especially in Alzheimer's Disease. Mechanisms of anesthesia mediated neurotoxicity and neurodegeneration, especially in the developing brains and in Alzheimer's disease.
Clincal science: Clinical use of Supraglottic Jet Oxygenationa and Ventilation (SJOV) in difficult airway management.
Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation Neurotoxicology and Teratology : In Press,2016.
Li Q, Xie P, Zha B, Wu JY: Supraglottic jet oxygenation and ventilation saved a patient with 'cannot intubate and cannot ventilate' emergent difficult airway Journal of Anesthesia 31 : 144-147,2017.
Yang ZY, Xu YH, Meng Q, Wang JW, YU DS: Supraglottic jet oxygenation and ventilation
during colonoscopy under monitored anesthesia
care: a controlled randomized clinical trial European Review for Medical and Pharmacological Sciences 20 : 1168-73,2016.
Wu CN, Ma WH, Wei JQ, Wei HF, Cen QY, Cai QX: Laryngoscope and a New Tracheal Tube Assist Lightwand Intubation in Difficult Airways due to Unstable Cervical Spine PloS One 10 : doi: 10.1371/journal.pone.0120231,2015.
Liang L: Dantrolene, A Treatment for Alzheimer’s Disease? Alzheimer Disease and Associated Disorders 29 : 1-5,2015.
Wu, Z, Yang B, Liu C, Liang G, Liu W, Pickup S, Meng Q, Tian, Y, Li S, Eckenhoff M: Long Term Dantrolene Treatment Reduced Intraneuronal Amyloid in Aged Alzheimer Triple Transgenic Mice Alzheimer's Disease and Associted Disorders In Press : 2015.
Yang B, Liang G, Khojasteh S, Wu Z, Joseph D: Comparison of Neurodegeneration and Cognitive Impairment in Neonatal Mice Exposed to Propofol or Isoflurane Plos One 9 : e99171. doi: 10.1371/journal.pone.0099171,2014.
Peng J, Drobish JK, Liang G, Wu Z, LIu C, Joseph D, Abdou H, Eckenhoff M: Anesthetic preconditioning inhibits isoflurane-mediated apoptosis in the developing rat brain Anesthesia and Analgesia 119 : 939-46,2014.
Joseph DJ, Peng Y, Mak DD, Cheung KH, Vais H, Foskett JK: General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening Anesthesiology 121 : 528-37,2014.
Levitt C: Supraglotic pulsatile jet oxygenation and ventilation during deep propofol sedation for upper gastrointestinal endoscopy in a morbidly obese patient Journal of Clinical Anesthesia 26 : 157-9,2014.
Zhao X, Yang Z, Liang G, Wu Z, Peng Y, Joseph DJ, Inan S: Dual effects of isoflurane on proliferation, differentiation and survival in human neuroprogenitor cells Anesthesiology 118 (3): 537-549,2013.
Wei H: Dual effects of neuroprotection and neurotoxicity by general anesthetics: Role of intracellular calcium homeostasis Progress in Neuropsychopharmacology and Biological Psychiatry 1833 : 2499-2510,2013.
Peng J, Liang G, Inan S, Wu Z, Joseph D, Meng Q, Peng Y, Eckenhoff M: Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice Neuroscience Letter 516 : 274-279,2012.
Peng J, Ye J, Zhao Y, Liang J, Huang H, Wei H: Supraglottic jet ventilation in difficult airway management Journal of Emergency Medicine 43 : 382-90,2012.
Role of calcium dysregulation in anesthetics mediated neurotoxicity Anesthesia and Analgesia 113 : 972-974,2011.
Wang Q, Liang G, Yang H, Wang S, Eckenhoff MF: The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease Toxicology and Applied Pharmacology 250 : 291-298,2011.
Dziewit JA: Supraglottic Jet Ventilation Assists Intubation in a Marfan’s Syndrome Patient with a Difficult Airway Journal of Clinical Anesthesia 23 : 407-409,2011.
Inan S: Cytoprotective effects of dantrolene: a ryanodine receptor antagonist Anesthesia and Analgesia 111 : 1400-10,2010.
Zhao Y, Liang G, Chen Q, Joseph DJ, Meng Q, Eckenhoff RG, Eckenhoff MF: Anesthetic induces neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors The Journal of Pharmacology and Experimental Therapeutics 333 : 1-9,2010.
Liang G, Ward C, Peng J, Zhao Y, Huang B: Isoflurane Causes Greater Neurodegeneration than an Equivalent Exposure of Sevoflurane in the Developing Brains of Neonatal Mice Anesthesiology 112 : 1325-34,2010.
Wang S, Peretich K, Zhao Y, Liang G, Meng Q: Anesthesia-induced neurodegeneration in fetal rat brains Pediatric Research 66 : 435-440,2009.
Wei H: Anesthesia, Calcium Homeostasis and Alzheimer's Disease Current Alzheimer Research 6 : 30-35,2009.
Yang H, Liang G, Hawkins B, Madesh M, Pierwola A: Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies Anesthesiology 109 : 243-50,2008.
Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M, Wang S: The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors Anesthesiology 108 : 251-60,2008.
Liang G, Wang Q, Li Y, Kang B, Eckenhoff MF, Eckenhoff RG: A Presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity Anesthesia and Analgesia 106 : 492-500,2008.
Li Y, Liang G,Wang S, Meng Q, Wang Q: Effects of fetal exposure to isoflurane on postnatal memory and learning in rats Neuropharmacology 53 : 942-950,2007.
Wei H, Liang G: Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity Neuroscience Letter 425 : 59-62,2007.
A novel endotracheal tube and methods to facilitate ventilation and placement in emergent airway management Resuscitation 70 : 438-444,2006.
Hiroi T, Wei H, Hough C, Leeds P: Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP 78 and Bcl-2 The Pharmacogenomics Journal : 1-10,2005.
Eckehnoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM: Inhaled Anesthetic Enhancement of Amyloid-beta oligomerization and cytotoxicity Anesthesiology 101 (3): 703-9,2004.
Wei H, Kang B, Wei W, Liang G, Meng QC, Li Y: Isoflurane and Sevoflurane Affect Cell Survival and Bcl-2/Bax Ratio Differently Brain Research 1037 : 139-147,2005.
Senatorov VV, Ren M, Kanai H, Wei H: Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease Molecular Psychiatry : 1-15,2004.
Wei H, Qin, ZH, Senatorov VV, Wei W, Wang Y, Qian Y: Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease Neuroscience 106 (3): 603-612,2001.
Wei H, Leeds PR, Qian Y, Wei W, Chen RW: ß-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment European Journal of Pharmacology 392 : 117-123,2000.
Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE: Neuronal apoptosis induced by pharmacological concentrations of 3-Hydroxykynurenine: Characterization and protection by dantrolene and Bcl-2 overexpression Journal of Neurochemistry 75 : 81-90,2000.
Chen RW, Saunders PA, Wei H, Li Z, Seth P: Involvement ofGlyceraldehyde-3Phosphate Dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 The Journal of Neuroscience 19 (21): 9654-9662,1999.
Wei H, Wei W, Bredesen D: Bcl-2 inhibits apoptosis induced by depletion of calcium from endoplasmic reticulum Journal of Neurochemistry 70 : 2305-2314,1998.
Wei H, Fiskum G, Rosenthal RE: Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain Molecular Chemical Neuropathology 30 : 25-39,1997.
Wei H: Dantrolene is cytoprotective in two models of neuronal cell death Journal of Neurochemistry 67 (6): 2390-2398,1996.
Perry DC, Wei H, Rosenthal RE: Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia reperfusion Brain Research 657 : 65-72,1994.
Wei H, Jin S, Ma l, Bi H: Experimental study of high frequency two-way jet ventilation Critical Care Medicine 20 : 420-423,1992.