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Harvey Rubin, MD, PhD

Harvey Rubin, MD, PhD Physician

Professor of Medicine

Dr. Rubin is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Infectious Diseases

Programs & Centers:

Board Certification:

  • Internal Medicine, 1979

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Columbia University
Residency: Brigham and Women's Hospital

Memberships

Department of Defense, National Energize the Chain, International Franklin Institute, Local Incentives for Global Health Impact Fund, International Interurban Clinical Club, John Morgan Society, Local John Scott Award Selection Committee, National Leiden Center for Natural Computing, University of Leiden, The Netherlands, Natural Computing Series, Springer-Verlag Press, NIH, National The College of Physicians of Philadelphia, Local

Hospital Affiliation

Dr. Rubin is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

The work in the lab is focused in three areas: elucidating the genetic and metabolic regulatory networks that allow tuberculosis to persist in the human host for years, determination of the molecular basis of serine protease inhibition and mathematical modeling of complex biomolecular systems.


Research:

Pathogenesis of dormancy in Mycobacterium tuberculosis.
It is widely believed that oxygen limitation, amino acid starvation and carbon source restriction are involved in establishing and maintaining Mycobacterium tuberculosis in a dormant state. Correspondingly, emergence from dormancy is related to a partial or complete amelioration of these conditions. We have identified and are studying three genetic and enzyme systems that comprise regulatory networks in Mtb that may be invovled in Mtb pathogenesis. These are: 1) ribonucleotide reductase systems that carry out the reduction of ribonucleotides to deoxyribonucleotides--the rate limiting enzymatic step in DNA synthesis, 2) the cytochrome system and, 3) the stringent response system that regulates the expression of a complex network of genes. This work is supported by the NIH.

Biomolecular Computation.
A new area of investigation known as biomolecular computation where complex computational operations are carried out using biomolecules, in particular using DNA. We showed how macromolecules can be manipulated to carry out fundamental logical operations and can be wired together as reversible logic gates. We are currently collaborating with members of the School of Engineering on modeling complex biological behavior using a hybrid systems approach that combines continuous and stochastic modalities. This work is supported by the NSF and DARPA

Enzymology and cell biology of serine proteases and serine protease inhibitors.
Serine proteases and serine protease inhibitors (serpins) play critical roles in a wide variety of biological processes including inflammation, coagulation and growth and development. We have proposed a general model for the mechanism of inhibition of serine proteases by serine protease inhibitors based on site directed mutagenesis, atomic resolution crystal structures and NMR spectroscopic analyses. We are currently exploring the consequences and extensions of this model. This work is supported by the NIH.

Selected Publications:

Schurig-Briccio LA, Yano T, Rubin H, Gennis RB: Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines Biochim Biophys Acta 1837 (7): 954-63,2014.

Yano, T, Rahimian, M, Aneja, KK, Schechter, NS, Rubin, H: Mycobacterium tuberculosis Type-II NADH-Menaquinone Oxidoreductase (NDH-2) catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sites Biochemistry 53 (7): 1179-90,2014.

Thayil SM, Morrison N, Schechter N, Rubin H, Karakousis PC: The Role of the Novel Exopolyphosphatase MT0516 in Mycobacterium tuberculosis Drug Tolerance and Persistence PLoS One : e28076,2011.

Yano, T., Kassovska-Bratinova, S., Teh, J-S., Winkler, J., Sullivan, K., Isaacs, A., Schechter, N.M., and Rubin, H: Reduction of clofazimine by mycobacterial type 2 NADH:Quinone oxidoreductase: A pathway for the generation of bactericidal levels of reactive oxygen species J Biol Chem : 2011.

Dawes SS, Qarner DF, Tsenova L, Timm J, McKinney JD, Kaplan G, Rubin H, Mizrahi V: Ribonucleotide reduction in Mycobacterium tuberculosis. Function and expression of the class Ib and class II ribonucleotide-reductase-encoding genes Infection and Immunity 71 : 6124-31,2003.

Dahl JL, Kraus CN, Boshoff HIM, Doan B, Foley K, Avarbock D, Kaplan G, Mizrahi V, Rubin H, Barry CE III: The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice Proc Natl Acad Sci USA 100 : 10026-10031,2003.

Alur R., Belta C., Ivancic F., Kumar V., Rubin H., Schug J., Sokolsky O. and Webb J.: Visual programming for modeling and simulation of bioregulatory networks, International Conference on High Performance Computing, Bangalore, India : 2002.

Alur R., Belta C., Kumar V., Mintz M., Pappas G. J., Rubin H., and Schug J.: Modeling and analyzing biomolecular networks Computing in Science and Engineering : 20-30,2002.

Plotnick, MI., Samakur, M., Wang, Z-M., Liu, X., Rubin, H., Schechter, NM., Selwood, T: Characterization of the Breakdown Process of HNE-Serpin Complexes Biochemistry 41 : 334-342,2002.

Que, X., Brinen, LS., Perkins, P., Herdman, S., Hirata, K., Torian, BE., Rubin, H., McKerrow, JH., Reed, SL: Cysteine Proteases From Distinct Cellular Compartments Are Recruited to Phagocytic Vesicles by Entamoeba histolytica Mol Biochem Parasitol 119 : 23-32,2002.

View all publications

Academic Contact Info

111 Clinical Research Building
Philadelphia, PA 19104
Phone: (215) 662-6475
Fax: (215) 662-7842
Patient appointments: 800-789-PENN (7366)

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