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H. Isaac Chen, MD

H. Isaac Chen, MD Physician

Assistant Professor of Neurosurgery at the Presbyterian Medical Center of Philadelphia and the Veteran's Administration Medical Center

Languages spoken:

  • Mandarin Chinese

Dr. Chen is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Clinical Expertise:

  • Astrocytoma
  • Brain Cancer
  • Brain Cells Regeneration
  • Brain Injury Rehabilitation
  • Brain Metastases
  • Brain Tumors
  • Cranial Base Surgery (Skull Base Surgery)
  • Glioma
  • Head Injury
  • Meningioma
  • Traumatic Brain Injury (TBI)
  • Traumatic Brain Injury (TBI) Surgery

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania


AANS/CNS Section on Tumros, National America Society for Stereotactic and Functional Neurosurgery, National American Association of Neurological Surgeons, National American Epilepsy Society, National Congress of Neurological Surgeons, National Pennsylvania Neurosurgical Society, Local Society for Neuroscience, National

Hospital Affiliation

Dr. Chen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.

Selected Publications:

Chen HI, Attiah M, Baltuch G, Smith DH, Hamilton RH, Lucas TH: Harnessing plasticity for the treatment of neurosurgical disorders World Neurosurgery 82 (5): 648-659,2014.

Chen HI, Bohman L, Loevner L, Lucas TH: Transorbital endoscopic amygdalo-hippocampectomy: a feasibility investigation Journal of Neurosurgery 120 (6): 1428-1436,2014.

Chen HI, Berman JI, Hudgins ED, Wolf RL, Lucas TH: Correlation of cortical and subcortical motor mapping with DTI- and HARDI-based tractography Congress of Neurological Surgeons : 2014.

Chen HI, Wolf JA, Smith DH: Development of biological data cable: optogenetic-based transmission across engineered cortical axonal tracts Society for Neuroscience : 2012.

Chen HI, Stiefel MF, Oddo M, Milby AH, Maloney-Wilensky E, Frangos S, Levine JM, Kofke WA, LeRoux PD: Detection of cerebral compromise with multimodality monitoring in patients with subarachnoid hemorrhage Neurosurgery 69 (1): 53-63,2011.

Evans SM, Jenkins KT, Chen HI, Jenkins WT, Judy KD, Hwang WT, Lustig RA, Magarelli DR, Judkins A, Grady MS, Hahn SM, Koch CJ: The relationship among hypoxia, proliferation, and outcome in patients with de novo glioblastoma: A pilot study Translational Oncology 3 (3): 160-169,2010.

Oddo M, Milby A, Chen HI, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel MF, Kofke WA, Levine JM, LeRoux PD: Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage Stroke 40 (4): 1275-1281,2009.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate infusion for intractable intracranial hypertension and its effects on brain oxygenation Neurosurgery 63 (5): 880-886,2008.

Chen HI, Bakshi A, Royo NC, Magge SN, Watson DJ: Neural stem cells as biological minipumps: A faster route to cell therapy for the CNS? Current Stem Cell Research and Therapy 2 (1): 13-22,2007.

Royo NC, LeBold D, Magge SN, Chen HI, Hauspurg A, Cohen AS, Watson DJ: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function Neuroscience 148 (2): 359-370,2007.

Academic Contact Info

The Hospital of the University of Pennsylvania
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)