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H. Isaac Chen, MD

H. Isaac Chen, MD Physician

Assistant Professor of Neurosurgery at the Presbyterian Medical Center of Philadelphia and the Veteran's Administration Medical Center

Dr. Chen is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

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Overall Ratings

Clinical Specialties

Clinical Expertise:

  • Astrocytoma
  • Brain Cancer
  • Brain Cells Regeneration
  • Brain Injury Rehabilitation
  • Brain Metastases
  • Brain Tumors
  • Cranial Base Surgery (Skull Base Surgery)
  • Glioma
  • Head Injury
  • Meningioma
  • Traumatic Brain Injury (TBI)
  • Traumatic Brain Injury (TBI) Surgery

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania


AANS/CNS Section on Tumors, National America Society for Stereotactic and Functional Neurosurgery, National American Association of Neurological Surgeons, National American Epilepsy Society, National Congress of Neurological Surgeons, National Pennsylvania Neurosurgical Society, Local Society for Neuroscience, National

Hospital Affiliation

Dr. Chen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.

Selected Publications:

Chen HI, Jgamadze D, Lim J, Mensah-Brown K, Wolf JA, Mills JA, Smith DH: Functional cortical axon tracts generated from human stem cell-derived neurons Tissue Engineering, Part A 25 (9-10): 736-45,2019.

Chen HI, Ming GL, Song H: Applications of cerebral organoids to clinical problems Developmental Dynamics 248 (1): 53-64,2019.

Piazza M*, Hitti FL*, Sinha S, Kvint S, Hudgins E, Baltuch G, Diaz-Arrastia R, Litt B, Davis KA, Lucas TH, Chen HI: Surgical outcomes in post-traumatic epilepsy: a single institutional experience Operative Neurosurgery accepted : 2018.

Ulyanova AV, Koch, PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber M, Russo RJ, Gagnon K, Smith DH, Chen HI, Johnson VE, Cullen DK, Wolf JA: Electrophysiological signature reveals laminar structure of the porcine hippocampus eNeuro 5 (5): ENEURO.0102-18.2018,2018.

Liaudanskaya V*, Jgamadze D*, Berk AN, Bischoff D, Gu BJ, Hawks-Mayer H, Whalen M, Chen HI^, Kaplan DL^ (*co-first author, ^co-senior author): Engineering advanced neural tissue to mitigate acute cerebral inflammation after brain transplantation in rats Biomaterials 192 : 510-522,2018.

Buch V, Yang AI, Lucas TL, Chen HI: Closed-loop stimulation methods: Current practice and future promise (Chapter 7) Deep Brain Stimulation: Techniques and Practice : 2018.

Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Duda JE, Espana RA, Cullen DK: Transplantable dopaminergic micro-tissue engineered neural networks to recapitulate the nigrostriatal pathway in Parkinson’s disease Journal of Tissue Engineering and Regenerative Medicine 12 (7): 1702-1716,2018.

Goel NJ, Mallela AN, Agarwal P, Abdullah KG, Choudhri OA, Kung DK, Lucas TH, Chen HI: Complications predicting perioperative mortality in patients undergoing elective craniotomy: an ACS-NSQIP analysis World Neurosurgery accepted : 2018.

Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network Journal of Neural Engineering 14 (2): 026016,2017.

Chen HI, Jgamadze D, Serruya, MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function Frontiers in Systems Neuroscience 10 : 1,2016.

Academic Contact Info

The Hospital of the University of Pennsylvania
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)