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H. Isaac Chen, MD

H. Isaac Chen, MD Physician

Assistant Professor of Neurosurgery at the Presbyterian Medical Center of Philadelphia and the Veteran's Administration Medical Center

Languages spoken:

  • Mandarin Chinese

Dr. Chen is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Clinical Expertise:

  • Abnormal Vertebrae
  • Absent Vertebrae
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Aneurysms
  • Ankylosing Spondylitis
  • Anterior Vertebral Body Tethering
  • Arteriovenous Malformations (AVM)
  • Artificial Disc Replacement Surgery in the Cervical Spine
  • Artificial Disc Replacement Surgery in the Lumbar Spine
  • Auditory Brainstem Implant
  • Back Injuries
  • Back Surgery
  • Biological Enhancement of Spinal Fusion
  • Bone Cyst
  • Bone Growth Stimulator
  • Bone Tumors
  • Brachial Plexus Injury
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumors
  • Broken Coccyx
  • Bulging Disc
  • Cauda Equina Syndrome
  • Cerebrospinal Fluid (CSF) Leak
  • Cervical Arthritis
  • Cervical Bone Spur
  • Cervical Compression Fracture
  • Cervical Decompression
  • Cervical Deformity
  • Cervical Disc Degeneration
  • Cervical Disc Disease
  • Cervical Disc Displacement
  • Cervical Disc Herniation
  • Cervical Laminoplasty
  • Cervical Laminotomy
  • Cervical Radiculopathy
  • Cervical Revision Surgery
  • Cervical Spinal Fracture
  • Cervical Spinal Fusion Surgery
  • Cervical Spinal Stenosis
  • Cervical Spine Surgery
  • Cervical Steroid Injection
  • Cholesteatoma
  • Chordoma
  • Coccyx Injury
  • Complex Spinal Deformities
  • Complex Spinal Surgery
  • Compression Fractures
  • Congenital Malformation of the Spine
  • Congenital Scoliosis
  • Cordotomy
  • Corpus Callosotomy Surgery
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • Decompression Laminectomy
  • Decompression Median Nerve At Elbow
  • Deep Brain Stimulation
  • Degenerative Spine Conditions
  • Disc Arthroplasty
  • Disc Replacement
  • Disc Surgery
  • Diskectomy
  • Dorsal Column Stimulator
  • Dystonia
  • Endoscopic Fusion
  • Epidural Injection
  • Epilepsy
  • Epilepsy Surgery
  • Essential Tremor
  • Extreme Lateral Interbody Fusion
  • Facet Injection
  • Facet Surgery
  • Failed Back Surgery Syndrome (FBSS)
  • Flatback Syndrome Post Harrington Rods
  • Foot Drag
  • Gamma Knife
  • Germ Cell Tumors
  • Glioblastoma
  • Growing Rods
  • Head and Neck Osteoma
  • Herniated Disc
  • Intraspinal Abscess
  • Junctional Kyphosis
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Kyphosis
  • Laminectomy
  • Laminoplasty
  • Lateral Access Spine Surgery
  • Lesion of Popliteal Nerve
  • Lesion of Posterior Tibial Nerve
  • Lesion of Sciatic Nerve
  • Low Back Surgery
  • Lower Back Injuries
  • Lower Back Pain
  • Lumbar Scoliosis
  • Lumbar Spinal Fracture
  • Lumbar Spinal Fusion
  • Lumbar Spinal Injury
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumbar Stress Fracture
  • Lumbosacral Plexus Lesion
  • Lumbosacral Radiculopathy
  • Microdiscectomy
  • Microsurgery
  • Microvascular Decompression
  • Minimally Invasive Partial Lumbar Discectomy
  • Minimally Invasive Spinal Fusion
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Myelopathy
  • Myelopathy Surgery
  • Neck Masses and Lumps
  • Neck Tumors
  • Neurocutaneous Disorders
  • Neuroendocrine Tumors
  • Neurofibromatosis Type 1 (NF1)
  • Neurogenic Claudication
  • Neuromuscular Scoliosis
  • Occipito-Cervical Fusion
  • Orbital Tumors
  • Osteoarthritis of the Spine
  • Parkinson's Disease
  • Peripheral Nerve Disorders
  • Peripheral Nerve Tumors
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Cervical Laminectomy and Fusion
  • Posterior Lumbar Laminectomy
  • Post-Laminectomy Kyphosis
  • Post-Laminectomy Syndrome
  • Prolactinoma
  • Radiculopathy
  • Revision of Spinal Surgery
  • Rhizotomy
  • Robotic Spine Surgery
  • Ruptured Intervertebral Disc
  • Sacral Nerve Stimulation
  • Sacroiliac Joint Block
  • Sacroiliac Joint Fusion
  • Sacroiliac Joint Surgery
  • Scheuermann Disease
  • Scheuermann's Kyphosis
  • Sciatica
  • Scoliosis Surgery
  • Selective Dorsal Rhizotomy
  • Skull Base Tumors
  • Spina Bifida
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Stimulator
  • Spinal Cord Surgery
  • Spinal Cyst Removal
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Fracture
  • Spinal Fusion
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Reconstruction
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tethering for Scoliosis
  • Spinal Tumor
  • Spine Decompression
  • Spine Deformity
  • Spine Deformity Correction Surgery
  • Spine Injuries
  • Spine Stapling
  • Spondylectomy
  • Spondyloarthropathy
  • Spondylolisthesis
  • Spondylosis
  • Spondylosis Surgery
  • Spondylosis With Myelopathy
  • Spondylosyndesis
  • Stereotactic Radiosurgery
  • Surgery for Sciatica
  • Surgical Treatment of Myelopathy
  • Tarlov Cysts
  • Tethered Spinal Cord
  • Thoracic Disc Herniation
  • Thoracic Laminectomy
  • Thoracic Spinal Fracture
  • Thoracic Spinal Fusion
  • Thoracic Spinal Injury
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Trigeminal Nerve Disorders
  • Ulnar Nerve Decompression
  • Ulnar Nerve Surgery
  • Vascular Malformations of the Spine
  • Vertebrae Surgery
  • Vertebral Epiphysitis
  • Vertebral Fracture
  • Vertebral Stapling
  • Visualase MRI-Guided Laser Ablation
  • X-Stop Surgery
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania

Memberships

AANS/CNS Section on Tumors, National Ad hoc member, Veterans Affairs RRD0 Study Section, National America Society for Stereotactic and Functional Neurosurgery, National American Association of Neurological Surgeons, National American Epilepsy Society, National Congress of Neurological Surgeons, National Pennsylvania Neurosurgical Society, Local Society for Neuroscience, National

Hospital Affiliation

Dr. Chen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.

Selected Publications:

Chen HI, Jgamadze D, Lim J, Mensah-Brown K, Wolf JA, Mills JA, Smith DH: Functional cortical axon tracts generated from human stem cell-derived neurons Tissue Engineering, Part A 25 (9-10): 736-45,2019.

Chen HI, Ming GL, Song H: Applications of cerebral organoids to clinical problems Developmental Dynamics 248 (1): 53-64,2019.

Piazza M*, Hitti FL*, Sinha S, Kvint S, Hudgins E, Baltuch G, Diaz-Arrastia R, Litt B, Davis KA, Lucas TH, Chen HI: Surgical outcomes in post-traumatic epilepsy: a single institutional experience Operative Neurosurgery accepted : 2018.

Ulyanova AV, Koch, PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber M, Russo RJ, Gagnon K, Smith DH, Chen HI, Johnson VE, Cullen DK, Wolf JA: Electrophysiological signature reveals laminar structure of the porcine hippocampus eNeuro 5 (5): ENEURO.0102-18.2018,2018.

Liaudanskaya V*, Jgamadze D*, Berk AN, Bischoff D, Gu BJ, Hawks-Mayer H, Whalen M, Chen HI^, Kaplan DL^ (*co-first author, ^co-senior author): Engineering advanced neural tissue to mitigate acute cerebral inflammation after brain transplantation in rats Biomaterials 192 : 510-522,2018.

Buch V, Yang AI, Lucas TL, Chen HI: Closed-loop stimulation methods: Current practice and future promise (Chapter 7) Deep Brain Stimulation: Techniques and Practice : 2018.

Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Duda JE, Espana RA, Cullen DK: Transplantable dopaminergic micro-tissue engineered neural networks to recapitulate the nigrostriatal pathway in Parkinson’s disease Journal of Tissue Engineering and Regenerative Medicine 12 (7): 1702-1716,2018.

Goel NJ, Mallela AN, Agarwal P, Abdullah KG, Choudhri OA, Kung DK, Lucas TH, Chen HI: Complications predicting perioperative mortality in patients undergoing elective craniotomy: an ACS-NSQIP analysis World Neurosurgery 118 : e195-e205,2018.

Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network Journal of Neural Engineering 14 (2): 026016,2017.

Chen HI, Jgamadze D, Serruya, MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function Frontiers in Systems Neuroscience 10 : 1,2016.

Academic Contact Info

The Hospital of the University of Pennsylvania
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)