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H. Isaac Chen, MD

H. Isaac Chen, MD Physician

Assistant Professor of Neurosurgery at the Presbyterian Medical Center of Philadelphia and the Veteran's Administration Medical Center

Languages spoken:

  • Mandarin Chinese

Dr. Chen is employed by Penn Medicine.

About Dr. H. Isaac Chen

My primary interest as a neurosurgeon-scientist is the restoration of function after the brain has been damaged. From the clinical side, I work in the areas of neurotrauma, functional neurosurgery (i.e., deep brain stimulation and epilepsy surgery), and the resection of tumors in and around eloquent brain tissue. I am interested in clinical trials examining new methods for restoring brain function, mapping brain activity after injury, and bringing new technologies such as augemented reality into the operating room. I also run a translational laboratory focused on rebuilding the circuitry of the brain using a combination of techniques drawn from stem cell biology, neural tissue engineering, and neural interface technologies.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Clinical Expertise:

  • Abnormal Vertebrae
  • Absent Vertebrae
  • Acoustic Neurofibromatosis
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Acoustic Neuroma Removal
  • Acromegaly
  • Anaplastic Astrocytoma
  • Anaplastic Ependymoma
  • Anaplastic Mixed Glioma
  • Anaplastic Oligoastrocytoma
  • Ankylosing Spondylitis
  • Anterior Temporal Lobectomy
  • Anterior Vertebral Body Tethering
  • Aqueductal Stenosis
  • Arachnoid Cyst
  • Arnold Chiari Malformation
  • Astrocytic Cancer
  • Astrocytoma Tumors
  • Awake Craniotomy
  • Back Injuries
  • Back Surgery
  • Benign Neoplasm of Brain
  • Biological Enhancement of Spinal Fusion
  • Biopsy of the Brain
  • Biopsy of the Skull
  • Bone Cyst
  • Bone Growth Stimulator
  • Bone Tumors
  • Brain Cancer Genomics
  • Brain Laceration
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumor Bleeding
  • Brain Tumors
  • Bulging Disc
  • Burr Hole
  • Cauda Equina Syndrome
  • Cavernous Hemangioma
  • Cavernous Sinus Thrombosis
  • Central Nervous System Infection
  • Central Nervous System Tumors
  • Central Venous Stenosis
  • Cerebellar Anomaly
  • Cerebellar Tremor
  • Cerebellar Tumor
  • Cerebral Cyst
  • Cerebral Decompression
  • Cerebral Edema
  • Cerebral Hernia
  • Cerebrospinal Fluid (CSF) Leak
  • Cerebrovascular Accident
  • Cervical Arthritis
  • Cervical Bone Spur
  • Cervical Compression Fracture
  • Cervical Decompression
  • Cervical Deformity
  • Cervical Disc Degeneration
  • Cervical Disc Disease
  • Cervical Disc Displacement
  • Cervical Disc Herniation
  • Cervical Laminoplasty
  • Cervical Laminotomy
  • Cervical Radiculopathy
  • Cervical Revision Surgery
  • Cervical Spinal Fracture
  • Cervical Spinal Fusion Surgery
  • Cervical Spinal Stenosis
  • Cervical Spine Surgery
  • Chiari Decompression
  • Cholesteatoma
  • Chordoma
  • Choroid Plexus Tumor
  • Cingulotomy
  • Clivus Chondroma
  • CNS Lymphoma
  • Colloid Cyst
  • Complex Spinal Surgery
  • Compression Fractures
  • Congenital Malformation of the Spine
  • Cordotomy
  • Corpus Callosotomy Surgery
  • Cortical Mapping
  • Cranial Nerve Disorders
  • Cranial Nerve Injuries
  • Cranial Nerve Palsy
  • Cranial Nerve Repair
  • Cranial Puncture
  • Craniectomy
  • Craniocele
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • CSF Shunt Removal
  • Decompression Laminectomy
  • Decompression Median Nerve At Elbow
  • Deep Brain Stimulation
  • Deep Brain Stimulation for Dystonia
  • Deep Brain Stimulation while Asleep
  • Deep Brain Stimulation while Awake
  • Degenerative Spine Conditions
  • Disc Surgery
  • Diskectomy
  • Dorsal Column Stimulator
  • Dural Based Tumor
  • Dural Sinus Thrombosis
  • Dystonia
  • EGFR Translocation
  • Electrocorticography
  • Embryonal Cell Tumors of the Brain
  • Embryonal Tumors
  • Encephalocele Repair
  • Endodermal Sinus Tumor
  • Endonasal Transsphenoidal Approach
  • Endoscopic Endonasal Approach
  • Endoscopic Neurosurgery
  • Endoscopic Third Ventriculostomy
  • Ependymoma
  • Epidural Hematoma
  • Epidural Hemorrhage
  • Epilepsy
  • Epilepsy Surgery
  • Essential Tremor
  • Evaluation for Epilepsy Surgery
  • Extradural Abscess
  • Facet Surgery
  • Facial Nerve Schwannoma
  • Facial Pain
  • Facial Spasm
  • Failed Back Surgery Syndrome (FBSS)
  • Fibrillary Astrocytoma
  • Foot Drag
  • Ganglioglioneurocytoma
  • Ganglioma
  • Ganglioneuroblastoma
  • Ganglioneurocytoma
  • Germ Cell Tumors
  • Germinoma
  • Glioblastoma
  • Glioma
  • Gliomatosis Cerebri
  • Gliosarcoma
  • Glomus Jugulare Tumor
  • Glossopharyngeal Neuralgia
  • Head and Neck Osteoma
  • Head Reconstruction
  • Hemangioblastoma
  • Hemangiopericytoma
  • Hemispherectomy
  • Herniated Disc
  • Hydrocephalus
  • Hypothalamic Hamartoma
  • Image Guided Biopsy of the Spine
  • Injury of Optic Chiasm
  • Intracranial Abscess
  • Intracranial Hemangioma
  • Intracranial Hemorrhage
  • Intracranial Hypotension
  • Intracranial Mass
  • Intraoperative MRI
  • Intraspinal Abscess
  • Intraventricular Endoscopy
  • Intraventricular Tumor
  • Junctional Kyphosis
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Kyphosis
  • Laminectomy
  • Laminoplasty
  • Lateral Access Spine Surgery
  • Leptomeningeal Carcinomatosis
  • Leptomeningeal Disease
  • Lesion of Median Nerve
  • Lesionectomies
  • Lesionectomy
  • Lhermitte-Duclos Disease
  • Lobectomy of Brain
  • Low Back Surgery
  • Lower Back Injuries
  • Lower Back Pain
  • Lumbar Drain
  • Lumbar Scoliosis
  • Lumbar Spinal Fracture
  • Lumbar Spinal Fusion
  • Lumbar Spinal Injury
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumbar Stress Fracture
  • Lumboperitoneal Shunt Placement
  • Lumbosacral Radiculopathy
  • Malignant Neoplasm of the Brain Stem
  • Malignant Neoplasm of the Cerebellum
  • Malignant Neoplasm of the Frontal Lobe
  • Malunion Fracture of the Spine
  • Medulloblastoma
  • Medulloepithelioma
  • Meningioma
  • Meningocele
  • Metastatic Brain Cancer
  • Microdiscectomy
  • Microneurosurgery
  • Microsurgery
  • Microvascular Decompression
  • Microvascular Surgery
  • Minimally Invasive Partial Lumbar Discectomy
  • Minimally Invasive Spinal Fusion
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Myelopathy
  • Myelopathy Surgery
  • Myxopapillary Ependymoma
  • Neck Injuries
  • Neck Masses and Lumps
  • Neck Tumors
  • Needle Biopsy of Brain
  • Needle Biopsy of Cerebral Meninges
  • Neoplasm of Brain Stem
  • Nerve Sheath Tumor
  • Neuroblastoma
  • Neurocutaneous Disorders
  • Neuroectodermal Tumor
  • Neuroendocrine Tumors
  • Neuroendoscopy
  • Neurofibromatosis
  • Neurofibromatosis Type 1 (NF1)
  • Neurofibromatosis Type 2
  • Neurofibrosarcoma
  • Neurogenic Claudication
  • Neuronal Glial Tumors
  • Normal Pressure Hydrocephalus
  • Occipito-Cervical Fusion
  • Olfactory Neuroblastoma
  • Oligoastrocytoma
  • Oligodendroglioma
  • Open Biopsy of the Brain
  • Optic Nerve Decompression
  • Optic Nerve Glioma
  • Optic Nerve Sheath Meningioma
  • Optic Nerve Surgery
  • Orbital Nerve Decompression
  • Orbital Tumors
  • Osteoarthritis of the Spine
  • Paraganglioma
  • Parkinson's Disease
  • Parkinson's Surgery
  • Peripheral Schwannoma
  • Periventricular Lesion
  • Periventricular Mass
  • Personal History of Malignant Neoplasm of Brain
  • Petrous Apex Tumor
  • Pilocytic Astrocytoma
  • Pineal Gland Parenchymal Tumor
  • Pineal Tumor
  • Pineoblastoma
  • Pituitary Adenoma
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Cervical Laminectomy and Fusion
  • Posterior Lumbar Laminectomy
  • Post-Laminectomy Kyphosis
  • Post-Laminectomy Syndrome
  • Primary Brain Tumor
  • Prolactinoma
  • Radiculopathy
  • Rathke's Cleft Cysts
  • Repair of Brain
  • Retinoblastoma
  • Revision of Spinal Surgery
  • Ruptured Intervertebral Disc
  • Schwannomatosis
  • Sciatica
  • Sinonasal Undifferentiated Carcinoma
  • Skull Base Approach
  • Skull Base Tumors
  • Skull Fracture
  • Spina Bifida
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Anomaly
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Stimulator
  • Spinal Cord Surgery
  • Spinal Cord Tumors
  • Spinal Cyst Removal
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Fracture
  • Spinal Fusion
  • Spinal Instrumentation
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Reconstruction
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tethering for Scoliosis
  • Spinal Tumor
  • Spine Decompression
  • Spine Deformity
  • Spine Injuries
  • Spondylectomy
  • Spondyloarthropathy
  • Spondylolisthesis
  • Spondylosis
  • Spondylosis Surgery
  • Spondylosis With Myelopathy
  • Spondylosyndesis
  • Spongioblastoma
  • Standard Transsphenoidal Approach
  • Stereotactic Brain Biopsy
  • Stereotactic EEG
  • Subarachnoid Hemorrhage
  • Subcaudate Tractotomy
  • Subdural Hematoma
  • Subdural Hemorrhage
  • Subependymal Giant Cell Astrocytoma
  • Subpial Transection
  • Superior Canal Dehiscence
  • Surgery for Sciatica
  • Surgery for Spasticity
  • Surgical Treatment of Myelopathy
  • Syringobulbia
  • Syringomyelia
  • Temporal Tumor
  • Tethered Spinal Cord
  • Thoracic Disc Herniation
  • Thoracic Laminectomy
  • Thoracic Spinal Fracture
  • Thoracic Spinal Fusion
  • Thoracic Spinal Injury
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Topectomy
  • Transnasal Repair CSF Leak
  • Transpetrosal Approaches
  • Trigeminal Nerve Disorders
  • Tuberous Sclerosis
  • Ulnar Nerve Decompression
  • Ulnar Nerve Surgery
  • Vagal Nerve Stimulator
  • Vagal Stimulation
  • Vascular Brain Tumors
  • Vascular Malformations of the Spine
  • Venous Malformation Brain
  • Ventricular Shunt
  • Ventriculo Peritoneal Shunt
  • Ventriculocisternostomy
  • Ventriculostomy
  • Vertebrae Surgery
  • Vertebral Epiphysitis
  • Vertebral Fracture
  • Visualase MRI-Guided Laser Ablation
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania

Memberships

AANS/CNS Section on Tumors, National Ad hoc member, Veterans Affairs RRD0 Study Section, National America Society for Stereotactic and Functional Neurosurgery, National American Association of Neurological Surgeons, National American Epilepsy Society, National Congress of Neurological Surgeons, National Pennsylvania Neurosurgical Society, Local Society for Neuroscience, National

Hospital Affiliation

Dr. Chen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.

Selected Publications:

Chen HI, Jgamadze D, Lim J, Mensah-Brown K, Wolf JA, Mills JA, Smith DH: Functional cortical axon tracts generated from human stem cell-derived neurons Tissue Engineering, Part A 25 (9-10): 736-45,2019.

Chen HI, Ming GL, Song H: Applications of cerebral organoids to clinical problems Developmental Dynamics 248 (1): 53-64,2019.

Piazza M*, Hitti FL*, Sinha S, Kvint S, Hudgins E, Baltuch G, Diaz-Arrastia R, Litt B, Davis KA, Lucas TH, Chen HI: Surgical outcomes in post-traumatic epilepsy: a single institutional experience Operative Neurosurgery accepted : 2018.

Ulyanova AV, Koch, PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber M, Russo RJ, Gagnon K, Smith DH, Chen HI, Johnson VE, Cullen DK, Wolf JA: Electrophysiological signature reveals laminar structure of the porcine hippocampus eNeuro 5 (5): ENEURO.0102-18.2018,2018.

Liaudanskaya V*, Jgamadze D*, Berk AN, Bischoff D, Gu BJ, Hawks-Mayer H, Whalen M, Chen HI^, Kaplan DL^ (*co-first author, ^co-senior author): Engineering advanced neural tissue to mitigate acute cerebral inflammation after brain transplantation in rats Biomaterials 192 : 510-522,2018.

Buch V, Yang AI, Lucas TL, Chen HI: Closed-loop stimulation methods: Current practice and future promise (Chapter 7) Deep Brain Stimulation: Techniques and Practice : 2018.

Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Duda JE, Espana RA, Cullen DK: Transplantable dopaminergic micro-tissue engineered neural networks to recapitulate the nigrostriatal pathway in Parkinson’s disease Journal of Tissue Engineering and Regenerative Medicine 12 (7): 1702-1716,2018.

Goel NJ, Mallela AN, Agarwal P, Abdullah KG, Choudhri OA, Kung DK, Lucas TH, Chen HI: Complications predicting perioperative mortality in patients undergoing elective craniotomy: an ACS-NSQIP analysis World Neurosurgery 118 : e195-e205,2018.

Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network Journal of Neural Engineering 14 (2): 026016,2017.

Chen HI, Jgamadze D, Serruya, MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function Frontiers in Systems Neuroscience 10 : 1,2016.

Academic Contact Info

The Hospital of the University of Pennsylvania
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3487
Patient appointments: 800-789-7366 (PENN)