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Gregory E. Supple, MD

Gregory E. Supple, MD Physician

Associate Professor of Clinical Medicine

Dr. Supple is employed by Penn Medicine.

About Dr. Gregory E. Supple

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2011
  • Clinical Cardiac Electrophysiology, 2012

Clinical Expertise:

  • Arrhythmia
  • Arrhythmia Device Lead Extraction
  • Atrial Fibrillation (Afib)
  • Atrial Fibrillation Ablation
  • Cardiac Arrest
  • Cardiac Sarcoidosis
  • Imaging of Pacemakers and Implantable Cardioverter Defibrillators (ICDs)
  • Implantable Cardiac Devices
  • Implantable Cardioverter Defibrillator
  • Pacemaker
  • Sick Sinus Syndrome
  • Supraventricular Tachycardia (SVT)
  • Ventricular Tachycardia
  • Wolff-Parkinson-White Syndrome

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Massachusetts General Hospital
Fellowship: Hospital of the University of Pennsylvania


American College of Cardiology, National American College of Cardiology, National Heart Rhythm Society, National

Hospital Affiliation

Dr. Supple is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Yaeger A, Cash NR, Parham T, Amaro A, Deo R, Frankel DS, Epstein AE, Santangeli P, Riley MP, Nazarian S, Lin D, Garcia FC, Schaller RD, Arkles JS, Supple GE, Kumareswaran R, Callans DJ, Marchlinski FE, Dixit S: Efficacy of a Nurse-Led Risk Factor Modification Program in Achieving Weight Loss in Obese Atrial Fibrillation Patients. Circulation: Cardiovascular Quality and Outcomes 11 (A146): 2018.

Shirai Y, Santangeli P, Liang JJ, Garcia FC, Supple GE, Frankel DS, Riley MP, Lin D, Schaller RD, Dixit S1, Callans DJ, Zado ES, Marchlinski FE: Anatomical proximity dictates successful ablation from adjacent sites for outflow tract ventricular arrhythmias linked to the coronary venous system. Europace : 2018.

Xie S, Kubala M, Liang JJ, Yang J, Desjardins B, Santangeli P, van der Geest RJ, Schaller R, Riley M, Supple G, Frankel DS, Callans D, Pac EZ, Marchlinski F, Nazarian S: Utility of ripple mapping for identification of slow conduction channels during ventricular tachycardia ablation in the setting of arrhythmogenic right ventricular cardiomyopathy. J Cardiovasc Electrophysiol : 2018.

Mendelson TB, Santangeli PM, Frankel DS, Arkles JS, Supple GE, Lin D, Riley MP, Callans DJ, Nazarian S, Hyman MC, Kumareswaran R, Epstein AE, Deo R, Dixit S, Garcia FC, Zado ES, Hutchinson MD, Sadek MM, Cooper JM, Marchlinski FE, Trerotola SO, Schaller RD: Feasibility of Complex Trans-Femoral Electrophysiology Procedures in Patients with Inferior Vena Cava Filters. Heart Rhythm : In Press,2018.

Gordon JP, Liang JJ, Rajeev Pathak, Zado ES, Garcia FC, Hutchinson MD, Santangeli P, Schaller RD, Frankel DS, Marchlinski FE, Supple GE: Percutaneous Cryoablation for Papillary Muscle Ventricular Arrhythmias after Failed Radiofrequency Catheter Ablation. J Cardiovasc Electrophysiol 29 (12): 1654-63,2018.

Shirai Y, Liang JJ, Garcia FC, Supple GE, Callans DJ, Zado ES, Marchlinski FE, Santangeli P: QRS Morphology Shift Following Catheter Ablation of Idiopathic Outflow Tract Ventricular Arrhythmias: Prevalence, Mapping Features and Ablation Outcomes. J Cardiovasc Electrophysiol 29 (12): 1664-71,2018.

Xie S, Kubala M, Liang JJ, Hayashi T, Park J, Padros IL, Garcia FC, Santangeli P, Supple GE, Frankel DS, Zado ES, Lin D, Schaller RD, Dixit S, Callans DJ, Nazarian S, Marchlinski FE: Lead I R-wave Amplitude to Differentiate Idiopathic Ventricular Arrhythmias with Left Bundle Branch Block Right Inferior Axis Originating from the Left versus Right Ventricular Outflow Tract. J Cardiovasc Electrophysiol 29 (11): 1515-22,2018.

Muser D, Liang JJ, Castro SA, Hayashi T, Enriquez A, Troutman GS, McNaughton NW, Supple G, Birati EY, Schaller R, Garcia FC, Frankel DS, Dixit S, Callans DJ, Zado ES, Marchlinski FE, Santangeli P: Outcomes with prophylactic use of percutaneous left ventricular assist devices in high-risk patients undergoing catheter ablation of scar-related ventricular tachycardia: A propensity-matched analysis. Heart Rhythm 15 (10): 1500-1506,2018.

Hayashi T, Liang JJ, Muser D, Shirai Y, Enriquez A, Garcia FC, Supple GE, Schaller RD, Frankel DS, Lin D, Nazarian S, Zado ES, Arkles J, Dixit S, Callans DJ, Marchlinski FE, Santangeli P: Epicardial Ventricular Tachycardia in Ischemic Cardiomyopathy: Prevalence, Electrophysiological Characteristics, and Long-term Ablation Outcomes. J Cardiovasc Electrophysiol : 2018.

Liang JJ, D'Souza BA, Betensky BP, Zado ES, Desjardins B, Santangeli P, Chik WW, Frankel DS, Callans DJ, Supple GE, Hutchinson MD, Dixit S, Schaller RD, Garcia FC, Lin D, Riley MP, Marchlinski FE: Importance of the Interventricular Septum as Part of the Ventricular Tachycardia Substrate in Nonischemic Cardiomyopathy. JACC Clin Electrophysiol 4 (9): 1155-1162,2018.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
Cardiovascular Medicine Division, Electrophysiology Section
9 Founders Pavilion

Philadelphia, PA 19104
Phone: (215) 615-3811
Patient appointments: 800-789-7366 (PENN)