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Gregory E. Supple, MD

Gregory E. Supple, MD Physician

Assistant Professor of Clinical Medicine

Dr. Supple is employed by Penn Medicine.

About Dr. Gregory E. Supple

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's May 2018 Top Docs issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2011
  • Clinical Cardiac Electrophysiology, 2012
  • Internal Medicine, 2008

Clinical Expertise:

  • Ablation of Idiopathic Ventricular Tachycardia
  • Ablation of Ischemic Ventricular Tachycardia
  • Atrial Fibrillation (Afib)
  • Atrial Flutter Ablation
  • Biventricular Device Optimization
  • Bradycardia
  • Cardiac Catheter Ablation
  • Electrocardiogram (EKG or ECG)
  • Electrocardiography (ECG or EKG)
  • Electrophysiology (EP) Testing
  • Epicardial Ablation
  • Heart Rhythms - Slow/Fast
  • Implantable Cardioverter Defibrillator
  • Intracardiac Echocardiography (ICE)
  • Pacemaker
  • Pulmonary Vein Antrum Isolation (PVAI)
  • Radiofrequency Ablation (RFA)
  • Supraventricular Tachycardia (SVT)
  • Tachycardia
  • Ventricular Tachycardia
  • Ventricular Tachycardia Ablation
  • Wolff-Parkinson-White Syndrome

Description of Clinical Expertise

ablation - Wolff-Parkinson-White syndrome (WPW)
atrial fibrillation
atrial fibrillation - pulmonary vein isolation
atrial flutter ablation
biventricular device optimization
cardiac ablation
defibrillator implantation
ECG - electrocardiography
epicardial ablation
heart rhythms - slow/fast
idiopathic tachycardia ablation
implantable cardioverter-defibrillator
intracardiac echocardiography
ischemic tachycardia ablation
pacemaker implantation
radiofrequency ablation
supraventricular tachycardia (SVT)
ventricular tachycardia
ventricular tachycardia ablations

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Massachusetts General Hospital
Fellowship: Hospital of the University of Pennsylvania


American College of Cardiology, National American College of Cardiology, National Heart Rhythm Society, National

Hospital Affiliation

Dr. Supple is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Muser D, Liang JJ, Castro SA, Hayashi T, Enriquez A, Troutman GS, McNaughton NW, Supple G, Birati EY, Schaller R, Garcia FC, Frankel DS, Dixit S, Callans DJ, Zado ES, Marchlinski FE, Santangeli P: Outcomes with prophylactic use of percutaneous left ventricular assist devices in high-risk patients undergoing catheter ablation of scar-related ventricular tachycardia: A propensity-matched analysis. Heart Rhythm 15 (10): 1500-1506,2018.

Hayashi T, Liang JJ, Muser D, Shirai Y, Enriquez A, Garcia FC, Supple GE, Schaller RD, Frankel DS, Lin D, Nazarian S, Zado ES, Arkles J, Dixit S, Callans DJ, Marchlinski FE, Santangeli P: Epicardial Ventricular Tachycardia in Ischemic Cardiomyopathy: Prevalence, Electrophysiological Characteristics, and Long-term Ablation Outcomes. J Cardiovasc Electrophysiol : 2018.

Xie S, Kubala M, Liang JJ, Hayashi T, Park J, Padros IL, Garcia FC, Santangeli P, Supple GE, Frankel DS, Zado ES, Lin D, Schaller RD, Dixit S, Callans DJ, Nazarian S, Marchlinski FE: Lead I R-wave Amplitude to Differentiate Idiopathic Ventricular Arrhythmias with Left Bundle Branch Block Right Inferior Axis Originating from the Left versus Right Ventricular Outflow Tract. J Cardiovasc Electrophysiol : 2018.

Shirai Y, Liang JJ, Garcia FC, Supple GE, Callans DJ, Zado ES, Marchlinski FE, Santangeli P: QRS Morphology Shift Following Catheter Ablation of Idiopathic Outflow Tract Ventricular Arrhythmias: Prevalence, Mapping Features and Ablation Outcomes. J Cardiovasc Electrophysiol : 2018.

Liang JJ, D'Souza BA, Betensky BP, Zado ES, Desjardins B, Santangeli P, Chik WW, Frankel DS, Callans DJ, Supple GE, Hutchinson MD, Dixit S, Schaller RD, Garcia FC, Lin D, Riley MP, Marchlinski FE: Importance of the Interventricular Septum as Part of the Ventricular Tachycardia Substrate in Nonischemic Cardiomyopathy. JACC Clin Electrophysiol 4 (9): 1155-1162,2018.

Liang JJ, Mohanty S, Fahed J, Muser D, Briceno DF, Burkhardt JD, Arkles JS, Supple GE, Frankel DS, Nazarian S, Garcia FC, Callans DJ, Dixit S, Di Biase L, Natale A, Marchlinski FE, Santangeli P: Bailout Atrial Balloon Septoplasty to Overcome Challenging Left Atrial Transseptal Access for Catheter Ablation of Atrial Fibrillation. JACC: Clinical Electrophysiol 4 (8): 1011-1019,2018.

Gordon JP, Liang JJ, Rajeev Pathak, Zado ES, Garcia FC, Hutchinson MD, Santangeli P, Schaller RD, Frankel DS, Marchlinski FE, Supple GE: Percutaneous Cryoablation for Papillary Muscle Ventricular Arrhythmias after Failed Radiofrequency Catheter Ablation. J Cardiovasc Electrophysiol : 2018.

Liang JJ, Elafros MA, Mullen MT, Muser D, Hayashi T, Enriquez A, Pathak RK, Zado ES, Santangeli P, Arkles JS, Schaller RD, Supple GE, Frankel DS, Garcia FC, Deo R, Lin D, Riley MP, Nazarian S, Dixit S, Marchlinski FE, Callans DJ: Anticoagulation use and clinical outcomes after catheter ablation in patients with persistent and longstanding persistent atrial fibrillation. J Cardiovasc Electrophysiol 29 (6): 823-832,2018.

Walsh K, Tschabrunn CM, Supple GE, Santangeli P, Marchlinski FE: The Crista Terminalis Catheter: A Marker to Avoid Phrenic Nerve Injury During Atrial Fibrillation Ablation. Heart Rhythm 15 (5): S239,2018.

Briceño D, Santangeli P, Liang JJ, Tschabrunn CM, Riley MP, Garcia FC, Supple GE, Lin D, Frankel DS, Schaller RD, Callans DJ, Zado ES, Marchlinski FE: Longitudinal Increase in Right Ventricular Volume is Associated with the Baseline Extent of Bipolar Voltage Indicated Scar but not Scar Progression in Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Heart Rhythm 15 (5): S344,2018.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
Cardiovascular Medicine Division, Electrophysiology Section
9 Founders Pavilion

Philadelphia, PA 19104
Phone: (215) 615-3811
Patient appointments: 800-789-7366 (PENN)