Description of Research Expertise:
My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.
Selected Publications:
Mehta, Krina; Ravimohan, Shruthi; Pasipanodya, Jotam; Srivastava, Shashikant; Modongo, Chawangwa; Zetola, Nicola; Weissman, Drew; Ivaturi, Vijay; Gumbo, Tawanda; Bisson, Gregory; Vinnard, Christopher: Optimizing ethambutol dosing among HIV/tuberculosis patients: A population pharmacokinetic modeling and simulation study Journal of Antimicrobial Chemotherapy In press : 2019.
Ravimohan S; Auld S; Maenetje P; Ratsela N; Mlotshwa M; Ncube I; Smith J; Mboyo-Di-Tamba V; Sebe M; Kossenkov A; Weissman1 D; Wallis R; Churchyard G; Kornfeld H; Bisson GP: Lung injury on antiretroviral therapy in adults with HIV/TB Clinical Infectious Diseases In press : 2019.
Auld SC, Maenetje P, Ravimohan S, Weissman D, Ncube I, Mlotshawa M, Ratsela N, Chase W, Vangu MDI-T, Wallis R, Churchyard G, Kornfeld H, Bisson GP: Declines in Lung Function after ART initiation in Adults with HIV and TB: A Potential Manifestation of Respiratory IRIS Clinical Infectious Diseases : 2019.
Ahmad N, Ahuja SD, Akkerman OW, Alffenaar J-WC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan P-C, Chan ED, Chang K-C, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Koh W-J: Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis Lancet 392 (10150): 821-834,2018.
Vujkovic M, Bellamy S, Zuppa A, Gastonguay M, Moorthy G, Ratshaa B, Han X, Steenhoff A, Mosepele M, Strom B, Bisson GP, Aplenc R, Gross R: Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana Pharmacogenomics J 18 (5): 678-688,2018.
Torgersen J, Bellamy SL, Ratshaa B, Han X, Mosepele M, Zuppa AF, Vujkovic M, Steenhoff AP, Bisson GP, Gross R: Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans Eur J Drug Metab Pharmacokinet : doi: 10.1007/s13318-018-0507-5,2018.
Jarvis JN, Leeme TB, Molefi M, Chofle AA, Bidwell G, Tsholo K, Tlhako N, Mawoko N, Patel RKK, Tenforde MW, Muthoga C, Bisson GP, Kidola J, Changalucha J, Lawrence D, Jaffar S, Hope W, Molloy SLF, Harrison TS: Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus–associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial Clinical Infectious Diseases : doi: 10.1093/cid/ciy515,2018.
Ngongondo McNeil, Miyahara S, Hughes M, Sun X, Bisson GP, Gupta A, Kumwenda J, Lavenberg J, Torres T, Nyirenda M, Kidonge K, Hosseinpour C, AIDS Clinical Trials Group A5274: Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial J Acquir Immune Defic Syndr 78 (1): 54-61,2018.
Ravimohan S, Nfanyana K, Tamuhla N, Tiemessen CT, Weissman D, Bisson GP: Common Variation in NLRP3 Is Associated With Early Death and Elevated Inflammasome Biomarkers Among Advanced HIV/TB Co-infected Patients in Botswana Open Forum Infect Dis : ofy075,2018.
Ravimohan S, Kornfeld H, Weissman D, Bisson GP: Tuberculosis and lung damage: from epidemiology to pathophysiology Eur Respir Rev 27 (147): pii: 170077,2018.