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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Dr. Bisson sees and treats patients at the Philadelphia VA Medical Center.
My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.
Krishnan S, Queiroz A, Guptal A, Gupte N, Bisson GP, Kumwenda J, Naidoo K, Mohapi L, Mave V, Mngqibisa R, Lama JR, Hosseinipour MC, Andrade BB, and Karakousis PC, on behalf of the ACTG A5274 REMEMBER NWCS 414 Study Team: Integrative multi-omics reveals serum markers of tuberculosis in advanced HIV Frontiers in Immunology : 2021.
Opollo V, Sun X, Lando R, Miyahara S, Torres TS, Hosseinpour MC, Bisson GP, Kumwenda J, Gupta A, Nyirenda M, Katendey K, Suryavanshi N, Beulah F, Shah NS, on behalf of the A5274 study team: The effect of TB treatment on health-related quality of life for
people with advanced HIV
INT J TUBERC LUNG DIS : 2020.
Zentner I, Back HM, Kagan L, Nagajyothi J, Subbian S, Pasipanodya J, Srivastava S, Gumbo T, Bisson GP, Vinnard C.: Redox imbalance and oxidative DNA damage during isoniazid treatment: A clinical and translational pharmacokinetic study BMJ : 2020.
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, Isaakadis P, Lange C, Menzies D, Migliori GB, Pape JW, Palmero D, Baghei P, Tabarsi P, Viiklepp P, Vilbrun S, Walsh J and Marks SM: Mortality in Adults with MDR-TB and HIV by ART and TB Drug Use: Individual Patient Data Meta-Analysis Lancet In press : 2020.
Mehta K, Ravimohan S, Pasipanodya JG, Srivastava S, Modongo C, Zetola NM, Weissman D, Ivaturi V, Gumbo T, Bisson GP, Vinnard C: Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study J Antimicrob Chemother : pii: dkz265,2019.
Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu M-D-T, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP: Lung injury on antiretroviral therapy in adults with HIV/TB Clin Infect Dis : pii: ciz560,2019.
Torgersen J, Bellamy SL, Ratshaa B, Han X, Mosepele M, Zuppa AF, Vujkovic M, Steenhoff AP, Bisson GP, Gross R: Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans Eur J Drug Metab Pharmacokinet 44 (2): 179-187,2019.
Jarvis JN, Leeme TB, Molefi M, Chofle AA, Bidwell G, Tsholo K, Tlhako N, Mawoko N, Patel RKK, Tenforde MW, Muthoga C, Bisson GP, Kidola J, Changalucha J, Lawrence D, Jaffar S, Hope W, Molloy SLF, Harrison TS: Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial Clin Infect Dis 68 (3): 393-401,2019.
Sereti Irini, Bisson Gregory P, Meintjes Graeme Ayton (Eds): HIV and Tuberculosis: A Formidable Alliance Springer International Publishing : 2019.
Ravimohan S, Maenetje P, Auld SC, Ncube I, Mlotshwa M, Chase W, Tiemessen CT, Vangu MdT, Wallis R, Churchyard G, Weissman D, Kornfeld H, Bisson GP: A common NLRC4 gene variant associates with inflammation and pulmonary function in HIV/TB Clin Infect Dis : 2019.
832 Blockley Hall423 Guardian DriveCenter for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania