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Sees patients age 18 and up
Sees patients age 18 and up
Dr. Bisson sees and treats patients at the Philadelphia VA Medical Center.
My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.
Maenetje P, Baik Y, Schramm D, Vangu MDT, Wallis RS, Mlotshwa M, Tiemessen CT, Li Y, Kornfeld H, Churchyard G, Auld SC, Bisson GP: Circulating biomarkers, FeNO, and lung function in patients with HIV and tuberculosis J Infect Dis In Press : 2023.
Gupta A, Sun X, Krishnan S, Matoga M, Pierre S, Mcintire K, Faesen L, Kityo C, Dadabhai S, Naidoo K, Samaneka W, Lama J, Veloso V, Vidya Mave, Lalloo U, Langat D, Hogg L, Bisson GP, Kumwenda J, Hosseinipour M, for the ACTG A5274/REMEMBER Study Team: Isoniazid adherence reduces mortality and incident tuberculosis at 96 weeks among adults initiating antiretroviral therapy with advanced HIV in multiple high burden settings Open Forum Infectious Diseases : 2022.
Baik Y, Maenetje P, Schramm D, Tiemessen C, Ncube I, Churchyard G, Wallis R, Vangu M, Kornfeld H, Li Y, Auld S, Bisson GP: Lung function and collagen 1a levels are associated with changes in six-minute walk test distance during treatment of TB among HIV-infected adults: a prospective cohort study BMC Pulmonary Medicine : 2022.
Mehta K, Narayanan N, Heysell S, Bisson GP, Subbian S, Kurepina N, Kreiswirth, BN, Vinnard C: Pharmacogenetic variability and the probability of pharmacodynamic target attainment during tuberculosis meningitis treatment: a physiologically based pharmacokinetic modeling approach Tuberculosis : 2022.
Matoga M, Bisson GP, Gupta A, Miyahara S, Sun X, Manabe YC, Kumwenda J, Malawi B, Kanyama C, Nyirenda M, Ngongondo M, Mbewe A, Moi DL, Wallis C, Mugerwa H, Hosseinipour MC, on behalf of the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Urine LAM Testing in Advanced HIV-Infected Adults in a Trial of Empiric TB Therapy Clin Infect Dis
73 (4): e870-e877,2021.
Krishnan S, Queiroz A, Guptal A, Gupte N, Bisson GP, Kumwenda J, Naidoo K, Mohapi L, Mave V, Mngqibisa R, Lama JR, Hosseinipour MC, Andrade BB, and Karakousis PC, on behalf of the ACTG A5274 REMEMBER NWCS 414 Study Team: Integrative Multi-Omics Reveals Serum Markers of Tuberculosis in Advanced HIV Frontiers in Immunology : 2021.
Auld SC, Kornfeld H, Maenetje P, Mlotshwa M, Chase W, Vangu MT, Torigian, DA, Wallis RS, Churchyard G, Bisson GP: Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis BMC Pulmonary Medicine 21 (1): 2021.
Opollo V, Sun X, Lando R, Miyahara S, Torres TS, Hosseinpour MC, Bisson GP, Kumwenda J, Gupta A, Nyirenda M, Katendey K, Suryavanshi N, Beulah F, Shah NS, on behalf of the A5274 study team: The effect of TB treatment on health-related quality of life for people with advanced HIV
Int J Tuberc Lung Dis
24 (9): 910-915,2020.
Ravimohan S, Maenetje P, Auld SC, Ncube I, Mlotshwa M, Chase W, Tiemessen CT, Vangu MdT, Wallis R, Churchyard G, Weissman D, Kornfeld H, Bisson GP: A common NLRC4 gene variant associates with inflammation and pulmonary function in HIV/TB Clin Infect Dis 71 (4): 2020.
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, Isaakadis P, Lange C, Menzies D, Migliori GB, Pape JW, Palmero D, Baghei P, Tabarsi P, Viiklepp P, Vilbrun S, Walsh J and Marks SM: Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis Lancet 396 (10248): 402-411,2020.
832 Blockley Hall423 Guardian DriveCenter for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania