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Gregory L. Beatty, MD, PhD

Gregory L. Beatty, MD, PhD Physician

Assistant Professor of Medicine

Dr. Beatty is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Medical Oncology

Programs & Centers:

Board Certification:

  • Medical Oncology, 2010

Clinical Expertise:

  • Esophageal Cancer
  • Gastrointestinal Cancer
  • Pancreatic Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

Aduro Biotech, National American Association For Cancer Research, National American Society Of Clinical Oncology, National American Society of Gene and Cell Therapy, National Array Biopharma, National AstraZeneca, International BioLineRx, International Bristol Myers Squibb, International Genmab, International Incyte Corporation, International Janssen Pharmaceuticals, International Merck & Co, International NCI Esophagogastric Immunotherapy CPTM, National NIH/NCI U01 Consortium for Pancreatic Ductal Adenocarcinoma Translation Studies on the Tumor Microenvironment, National Opsona Therapeutics, International Pancreatic Cancer Action Network (PanCAN), National Seattle Genetics, National The American Society for Clinical Investigation Membership., National Vaccinex, National

Hospital Affiliation

Dr. Beatty is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My laboratory incorporates both basic science research and clinical investigation to examine the role of innate immunity, in particular monocytes/macrophages, in regulating tumor biology in pancreas cancer as well as other upper gastrointestinal malignancies. Our central hypothesis is that macrophages are key regulators of tumor biology.

Clinical research in the laboratory uses patient-derived samples to understand the role of macrophage biology in metastatic disease and therapeutic efficacy.

Preclinical research in the laboratory uses a genetically engineered mouse model of pancreas cancer in combination with advanced imaging strategies to study macrophage biology within the tumor microenvironment. This preclinical research platform allows for the study of basic immune biology within the tumor microenvironment as well as the rapid screening of novel immunotherapeutic strategies, including cell and gene therapies, for the treatment of cancer.

Studies in the laboratory focus on understanding 1) the signaling pathways that regulate cross-talk between macrophages and tumor cells in vivo, 2) the role of hematopoietic and non-hematopoietic cells in regulating macrophage biology within tumors, 3) the cellular trafficking of macrophages to primary and metastatic lesions, 4) strategies to harness macrophages for anti-tumor therapy, and 5) the impact of chemotherapy/radiation therapy on macrophage biology within tumors.

Selected Publications:

Vonderheide RH, Bajor DL, Winograd R, Evans RA, Bayne LJ, Beatty GL.: CD40 immunotherapy for pancreatic cancer Cancer Immunol Immunother 62 (5): 949-54,2013.

Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH.: T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res 1 (1): 26-31,2013 .

Bayne, L.J., Beatty, G.L., Jhala, N., Clark, C.E., Rhim, A.D., Stanger, B.Z., and R.H. Vonderheide: Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer Cancer Cell 21 : 822-35.,2012 .

Rhim AD, Mirek ET, Aiello, NM, Maitra A, Bailey J.M, McCallister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, BZ Stanger: EMT and dissemination precede pancreatic tumor formation Cell 148 : 349-61,2012.

Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun WJ, Huhn RD, Song WR, Li DG, Sharp LL, Torigian DA, O'Dwyer PJ, Vonderheide RH: CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans. Science 331 (6024): 1612-1616,2011.

Beatty GL, Smith JS, Reshef R, Patel KP, Colligon TA, Vance BA, Frey NV, Johnson FB, Porter DL, Vonderheide RH: Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen-specific CD8(+) T Cells After Allogeneic Stem Cell Transplantation. Clin Cancer Res 15 (15): 4944-4953,2009.

Clark CE, Beatty GL, Vonderheide RH: Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer. Cancer Lett 279 (1): 1-7,2009.

Dominiecki ME, Beatty GL, Pan ZK, Neeson P, Paterson Y: Tumor sensitivity to IFN-gamma is required for successful antigen-specific immunotherapy of a transplantable mouse tumor model for HPV-transformed tumors. Cancer Immunol Immunother 54 (5): 477-488,2005.

Beatty GL, Paterson Y: IFN-gamma signaling in antigen loss tumor variants plays a role in the bystander killing effect induced by recombinant Listeria. Federation of American Societies for Experimental Biology Journal 13 (4): A297-A297,1999.

Beatty GL, Paterson Y: IFN-gamma can promote tumor evasion of the immune system in vivo by down-regulating cellular levels of an endogenous tumor antigen. J Immunol 165 (10): 5502-5508,2000.

Beatty GL, Paterson Y: IFN-gamma-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4(+) T cells requires tumor responsiveness to IFN-gamma. J Immunol 166 (4): 2276-2282,2001.

Academic Contact Info

University of Pennsylvania Perelman School of Medicine
Perelman Center for Advanced Medicine
South Pavilion, Rm 8-107
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104-5156

Philadelphia, PA 19104-5156
Phone: (215) 746-7764
Patient appointments: 800-789-7366 (PENN)