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Giorgos C. Karakousis, MD

Giorgos C. Karakousis, MD Surgeon

Assistant Professor of Surgery at the Hospital of the University of Pennsylvania Associate Professor of Surgery at the Hospital of the University of Pennsylvania

Languages spoken:

  • Greek

Dr. Karakousis is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Endocrine and Oncologic Surgery

Programs & Centers:

Board Certification:

  • Surgery, 2008

Clinical Expertise:

  • Adrenal Cancer
  • Adrenal Gland Tumors
  • Anal Cancer
  • Bile Duct Cancer
  • Cancer Surgery
  • Colon Cancer
  • Endocrine Tumors
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Carcinoid Tumor
  • Intra-arterial Chemotherapy for Liver Cancer
  • Isolated Limb Perfusion
  • Laparoscopy
  • Liver Cancer
  • Melanoma
  • Melanoma Lymph Node Mapping
  • Melanoma Surgery
  • Neuroendocrine Tumors
  • Pancreatic Cancer
  • Parathyroid Gland Removal Surgery
  • Rectal Cancer
  • Sarcoma
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)
  • Thyroid Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Memorial Sloan-Kettering Cancer Center


American College of Surgeons (ACS), National American Society of Clinical Oncology, National Association for Academic Surgery, National Philadelphia Academy of Surgery, Local Scientific Advisory Board, Melanoma International Foundation, National Scientific Review Panel for Review of Department of Defense Grants for Skin Cancer Section, National Scientific Review Panel for Review of Department of Defense Grants for Skin Cancer Section, National Society of Surgical Oncology, National State of Melanoma Meeting; Resistance to therapy and adjuvant therapy section; sponsored by Melanoma Research Foundation at Society of Melanoma Research Meeting, San Francisco, CA, National

Hospital Affiliation

Dr. Karakousis is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Ecker Brett L, McMillan Matthew T, Datta Jashodeep, Lee Major K, Karakousis Giorgos C, Vollmer Charles M, Drebin Jeffrey A, Fraker Douglas L, Roses Robert E: Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score-matched analysis of a nationwide clinical oncology database. Cancer 123 (6): 967-976,2017.

Huang Alexander C, Postow Michael A, Orlowski Robert J, Mick Rosemarie, Bengsch Bertram, Manne Sasikanth, Xu Wei, Harmon Shannon, Giles Josephine R, Wenz Brandon, Adamow Matthew, Kuk Deborah, Panageas Katherine S, Carrera Cristina, Wong Phillip, Quagliarello Felix, Wubbenhorst Bradley, D'Andrea Kurt, Pauken Kristen E, Herati Ramin S, Staupe Ryan P, Schenkel Jason M, McGettigan Suzanne, Kothari Shawn, George Sangeeth M, Vonderheide Robert H, Amaravadi Ravi K, Karakousis Giorgos C, Schuchter Lynn M, Xu Xiaowe: T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature : 2017.

Karakousis Giorgos, Gimotty Phyllis A, Bartlett Edmund K, Sim Myung-Shin, Neuwirth Madalyn G, Fraker Douglas, Czerniecki Brian J, Faries Mark B: Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis. Annals of surgical oncology 24 (4): 952-959,2017.

Bailey Elizabeth A, Hoffman Rebecca L, Wirtalla Christopher, Karakousis Giorgos, Kelz Rachel R: Development and validation of a prediction model for patients discharged to post-acute care after colorectal cancer surgery. Surgery 161 (4): 1049-1057,2017.

Ecker Brett L, Peters Madalyn G, McMillan Matthew T, Sinnamon Andrew J, Zhang Paul J, Kelz Rachel R, Roses Robert E, Drebin Jeffrey A, Fraker Douglas L, Karakousis Giorgos C: Implications of Lymph Node Evaluation in the Management of Resectable Soft Tissue Sarcoma. Annals of surgical oncology 24 (2): 425-433,2017.

Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC: A prognostic model for resectable soft tissue and cutaneous angiosarcoma Journal of Surgical Oncology : 2016 (Epub ahead of print).

Neuwirth MG, Bartlett EK, Roses RE, Fraker DL, Kelz RR, Karakousis GC: Obesity is not associated with increased morbidity in patients undergoing cytoreductive surgery with intraperitoneal chemotherapy Journal of Surgical Oncology : 2016 (Epub ahead of print).

Ecker B L, McMillan M T, Datta J, Dempsey D T, Karakousis G C, Fraker D L, Drebin J A, Mamtani R, Giantonio B J, Roses R E: Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study. European journal of cancer (Oxford, England : 1990) 69 : 135-141,2016.

Neuwirth Madalyn G, Bartlett Edmund K, Newton Andrew D, Fraker Douglas L, Kelz Rachel R, Roses Robert E, Karakousis Giorgos C: Morbidity and mortality after total splenectomy for lymphoid neoplasms. The Journal of surgical research 205 (1): 155-62,2016.

Lu H, Liu S, Zhang G, Kwong LN, Zhu Y, Miller JP, Hu Y, Zhong W, Zeng J, Wu L, Krepler C, Sproesser K, Xiao M, Xu W, Karakousis GC, Schuchter LM, Field J, Zhang PJ, Herlyn M, Xu X, Guo W: Oncogenic BRAF-mediated melanoma cell invasion Cell Reports : 2016.

Academic Contact Info

Division of Endocrine & Oncologic Surgery
Hospital of the University of Pennsylvania
3400 Spruce St., 4 Silverstein

Philadelphia, PA 19104
Phone: 215-662-2083
Fax: 215-662-7476
Patient appointments: 800-789-7366 (PENN)

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