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Geoffrey Aguirre, MD, PhD

Geoffrey Aguirre, MD, PhD Physician

Associate Professor of Neurology Associate Professor

Dr. Aguirre is employed by Penn Medicine.

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Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 2005

Clinical Expertise:

  • Cognitive Neurology

Description of Clinical Expertise

My sub-speciality in Behavioral Neurology, and I treat patients with a variety of disturbances of visual perception, thinking and memory.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania


American Academy of Neurology, National Cognitive Neuroscience Society, International National Science Foundation, ad-hoc grant reviewer, National Organization for Human Brain Mapping, International Vision Sciences Society, International

Hospital Affiliation

Dr. Aguirre is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.

Selected Publications:

Cideciyan Artur V, Aguirre Geoffrey K, Jacobson Samuel G, Butt Omar H, Schwartz Sharon B, Swider Malgorzata, Roman Alejandro J, Sadigh Sam, Hauswirth William W: Pseudo-fovea formation after gene therapy for RPE65-LCA. Investigative ophthalmology & visual science 56 (1): 526-37,2015.

Butt Omar H, Benson Noah C, Datta Ritobrato, Aguirre Geoffrey K: Hierarchical and homotopic correlations of spontaneous neural activity within the visual cortex of the sighted and blind. Frontiers in human neuroscience 9 : 25,2015.

Persichetti Andrew S, Aguirre Geoffrey K, Thompson-Schill Sharon L: Value Is in the Eye of the Beholder: Early Visual Cortex Codes Monetary Value of Objects during a Diverted Attention Task. Journal of cognitive neuroscience : 1-9,2014.

Spitschan Manuel, Jain Sandeep, Brainard David H, Aguirre Geoffrey K: Opponent melanopsin and S-cone signals in the human pupillary light response. Proceedings of the National Academy of Sciences of the United States of America 111 (43): 15568-72,2014.

Cucchiara Brett, Datta Ritobrato, Aguirre Geoffrey K, Idoko Kimberly E, Detre John: Measurement of visual sensitivity in migraine: Validation of two scales and correlation with visual cortex activation. Cephalalgia : an international journal of headache : 2014.

Benson Noah C, Butt Omar H, Brainard David H, Aguirre Geoffrey K: Correction of distortion in flattened representations of the cortical surface allows prediction of v1-v3 functional organization from anatomy. PLoS computational biology 10 (3): e1003538,2014.

Datta Ritobrato, Aguirre Geoffrey K, Hu Siyuan, Detre John A, Cucchiara Brett: Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura. Cephalalgia 33 (6): 365-74,2013.

Butt Omar H, Benson Noah C, Datta Ritobrato, Aguirre Geoffrey K: The fine-scale functional correlation of striate cortex in sighted and blind people. The Journal of Neuroscience 33 (41): 16209-19,2013.

Cucchiara Brett, Wolf Ronald L, Nagae Lidia, Zhang Quan, Kasner Scott, Datta Ritobrato, Aguirre Geoffrey K, Detre John A: Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PloS one 8 (7): e71007,2013.

Benson Noah C, Butt Omar H, Datta Ritobrato, Radoeva Petya D, Brainard David H, Aguirre Geoffrey K: The retinotopic organization of striate cortex is well predicted by surface topology. Current biology 22 (21): 2081-5,2012.

View all publications

Academic Contact Info

Department of Neurology
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3390
Patient appointments: 800-789-7366 (PENN)

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