Description of Research Expertise:
Diet, the Gut Microbiome, and Host Metabolism
Dr. Wu is the Ferdinand G. Weisbrod Professor in Gastroenterology at the Perelman School of Medicine at the University of Pennsylvania where he is the Associate Chief for Research in the Division of Gastroenterology and is also the Associate Director of the Center for Molecular Studies in Digestive and Liver Disease. He is currently Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the American Association of Physicians. The research programs in the Wu laboratory focus on the mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism. Growing evidence suggests that diet impacts upon both the structure and function of the gut microbiota that, in turn, influences the host in fundamental ways. Current areas of investigation include the effect of diet on the composition of the gut microbiota and its subsequence effect on host metabolism related to nitrogen balance as well as its impact on metabolic pathways in the intestinal epithelium, principally fatty acid oxidation. Through a UH3 roadmap initiate grant, he is helping to direct a project investigating the impact of diet on the composition of the gut microbiome and its relationship to therapeutic responses associated with the treatment of patients with Crohn’s disease using an elemental diet. Finally, Dr. Wu is leading a multidisciplinary group of investigators using phosphorescent nanoprobe technology to examine the dynamic oxygen equilibrium between the host and the gut microbiota at the intestinal mucosal interface.
Lindsay Albenberg, DO
Lillian Chau, MS
Elliot Friedman, PhD
Josephine Ni, MD
Ting-Chin David Shen, MD
Sarah Smith, PhD
Erika Panfen, BS
Jack Jiang, BS
Ni J, Shen TCD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffman C, Rivas G, Albenberg L, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD: A Role for Bacterial Urease in Crohn's Disease and Gut Dysbiosis Science Translational Medicine : 2017.
Shen TC, Chehoud C, Ni J, Hsu E, Chen YY, Bailey A, Laughlin A, Bittinger K, Bushman FD: Dietary Regulation of the Gut Microbiota Engineered by a Minimal Defined Bacterial Consortium PLoS One 11 : e0155620,2016.
Sartor RB: Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches Gastroenterology : 2016.
Yang Y, Owyang C: East Meets West: The Increasing Incidence of Inflammatory Bowel Disease in Asia as a Paradigm for Environmental Effects on the Pathogenesis of Immune-Mediated Disease Gastroenterology : 2016.
Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, Albenberg L, Sinha R, Compher C, Gilroy E, Nessel L, Grant A, Chehoud C, Li H, Wu GD: Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's Disease Cell Host Microbe 18 (4): 489-500,2015.
Kelsen J, Bittinger K, Pauly-Hubbard H, Posivak L, Grunberg S, Baldassano R, Lewis JD, Wu GD: Alterations of the subgingival microbiota in pediatric Crohn's disease studied longitudinally in discovery and validation cohorts Inflammatory Bowel Disease Epub ahead of print : 2015.
Lee D, Baldassano RN, Otley AR, Albenberg L, Griffiths AM, Compher C, Chen EZ, Li H, Gilroy E, Nessel L, Grant A, Chehoud C, Bushman FD, Wu GD: Comparative effectiveness of nutritional and biological therapy in North American children with active Crohn's Disease Inflammatory Bowel Disease 21 (8): 1786-93,2015.
Chehoud C, Albenberg LG, Judge C, Hoffmann C, Grunberg S, Bittinger K, Baldassano RN, Lewis JD, Bushman FD: Fungal signature in the gut microbiota of pediatric patients with inflammatory bowel disease Inflammatory bowel diseases 21 (8): 1948-56,2015.
Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD: Engineering the gut microbiota to treat hyperammonemia Journal of Clinical Investigation 125 (7): 2841-50,2015.
Bryson AL, Hwang Y, Sherrill-Mix S, Wu GD, Lewis JD, Black L, Clark TA: Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9 mBio 6 (3): 00648-15,2015.
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