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Gary D. Wu, MD

Gary D. Wu, MD Physician

Associate Chief for Research, Division of Gastroenterology
Associate Director, Center for Molecular Studies in Digestive and Liver Disease
Director, Molecular Biology Core
Ferdinand G. Weisbrod Professor in Gastroenterology
Professor of Pediatrics

Dr. Wu is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 1991
  • Internal Medicine, 1989

Clinical Expertise:

  • Endoscopy
  • Inflammatory Bowel Disease (IBD)

Practice Locations and Appointments

  • Gastroenterology

    Perelman Center for Advanced Medicine South Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Northwestern University Feinberg School of Medicine
Residency: University of Minnesota Hospitals
Fellowship: University of Michigan Medical Center

Memberships

American Gastroenterological Association, National Crohn's and Colitis Foundation of America (CCFA), National Crohn's and Colitis Foundation of Canada, International Digestive Disease Research Center (DDRC) at the University of North Carolina, National Digestive Disease Research Center (DDRC) at Washington University St. Louis, National Gastroenterology Research Group, National Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network, National NIH Study Section, National VA Merit Review Board, National

Hospital Affiliation

Dr. Wu is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.

Research

Description of Research Expertise:

Research Program
Diet, the Gut Microbiome, and Host Metabolism

Program Summary
Dr. Wu is the Ferdinand G. Weisbrod Professor in Gastroenterology at the Perelman School of Medicine at the University of Pennsylvania where he is the Associate Chief for Research in the Division of Gastroenterology and is also the Associate Director of the Center for Molecular Studies in Digestive and Liver Disease. He is currently Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the American Association of Physicians. The research programs in the Wu laboratory focus on the mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism. Growing evidence suggests that diet impacts upon both the structure and function of the gut microbiota that, in turn, influences the host in fundamental ways. Current areas of investigation include the effect of diet on the composition of the gut microbiota and its subsequence effect on host metabolism related to nitrogen balance as well as its impact on metabolic pathways in the intestinal epithelium, principally fatty acid oxidation. Through a UH3 roadmap initiate grant, he is helping to direct a project investigating the impact of diet on the composition of the gut microbiome and its relationship to therapeutic responses associated with the treatment of patients with Crohn’s disease using an elemental diet. Finally, Dr. Wu is leading a multidisciplinary group of investigators using phosphorescent nanoprobe technology to examine the dynamic oxygen equilibrium between the host and the gut microbiota at the intestinal mucosal interface.

Lab personnel:
Lindsay Albenberg
Lillian Chau
Christel Chehoud
Sue Ann Keilbaugh, PhD
Andrew Lin
Josephine Ni, MD
Ting-Chin David Shen, MD
Sarah Smith, PhD

Selected Publications:

Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, Albenberg L, Sinha R, Compher C, Gilroy E, Nessel L, Grant A, Chehoud C, Li H, Wu GD, Bushman FD.: Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's Disease Cell Host Microbe 18 (4): 489-500,2015.

Kelsen J, Bittinger K, Pauly-Hubbard H, Posivak L, Grunberg S, Baldassano R, Lewis JD, Wu GD, Bushman FD: Alterations of the subgingival microbiota in pediatric Crohn's disease studied longitudinally in discovery and validation cohorts Inflammatory Bowel Disease Epub ahead of print : 2015.

Lee D, Baldassano RN, Otley AR, Albenberg L, Griffiths AM, Compher C, Chen EZ, Li H, Gilroy E, Nessel L, Grant A, Chehoud C, Bushman FD, Wu GD, Lewis JD: Comparative effectiveness of nutritional and biological therapy in North American children with active Crohn's Disease Inflammatory Bowel Disease 21 (8): 1786-93,2015.

Chehoud C, Albenberg LG, Judge C, Hoffmann C, Grunberg S, Bittinger K, Baldassano RN, Lewis JD, Bushman FD, Wu GD: Fungal signature in the gut microbiota of pediatric patients with inflammatory bowel disease Inflammatory bowel diseases 21 (8): 1948-56,2015.

Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD: Engineering the gut microbiota to treat hyperammonemia Journal of Clinical Investigation 125 (7): 2841-50,2015.

Bryson AL, Hwang Y, Sherrill-Mix S, Wu GD, Lewis JD, Black L, Clark TA, Bushman FD: Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9 mBio 6 (3): 00648-15,2015.

Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis JD: Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production Gut : Epub ahead of print,2014.

Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD: Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota Gastroenterology 14 (5): 1055-63,2014.

Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing Genome Biology 15 (10): 487,2014.

Wu, GD: Diet, the gut microbiome and the metabolome in IBD Nestle Nutr Inst Workshop Series (79): 73-82,2014.

View all publications

Academic Contact Info

421 Curie Boulevard
9th Floor Biomedical Research Building

Philadelphia, PA 19104
Phone: (215) 898-0158
Patient appointments: 800-789-PENN (7366)

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