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Frederick S. Kaplan, MD

Frederick S. Kaplan, MD Physician

Chief, Division of Molecular Orthopaedic Medicine, Department of Orthopaedic Surgery Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine in Orthopaedic Surgery

Dr. Kaplan is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
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About Dr. Frederick S. Kaplan

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Philadelphia magazine's Top Docs issues in 2007, 2008, 2012, 2013, 2018, and 2019

Clinical Specialties


  • Orthopaedic Surgery

Programs & Centers:

  • Metabolic Bone Disease Services

Clinical Expertise:

  • Fibrodysplasia Ossificans Progressiva (FOP)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: Hospital of the University of Pennsylvania


Academic Orthopaedic Society (AOS), Alpha Omega Alpha, National American Academy of Orthopaedic Surgeons, National American Society for Gravitational and Space Biology, National American Society for Microbiology, Arthritis Foundation, Belgian FOP Association (FOP Belgium), Charles Herndon Orthopaedic Society (2006), National College of Physicians of Philadelphia, College of Physicians of Philadelphia, Edgar L. Ralston Society, European Neuromuscular Center, Federation of American Societies for Experimental Biology, Förderverein für Fibrodysplasia Ossificans Progressiva-Ekrankte (FOPe. V.) Germany, Foundation Program Committee, Greater Philadelphia Philosophy Consortium (1990), International Fibrodysplasia Ossificans Progressiva Association (IFOPA), International International Science Foundation, Intl. Society of Bone & Soft Tissue Densitometry, Johns Hopkins Medical and Surgical Society, Medical Research Council; London, National Cancer Institute of Canada, National Institutes of Health of the United States, National Organization for Rare Disorders, National Osteoporosis Foundation, Orthopaedic Research and Education Foundation (OREF), Orthopaedic Research Society, Phi Beta Kappa, Progressive Osseous Heteroplasia Association (POHA), International Research Advisory Panel, The National Paget's Disease Registry, Swiss National Science Foundation, The Benjamin Franklin Society, The Institute of Medicine of the National Academy of Sciences of the United States, National The John Morgan Society, The Lindback Society, The New York Academy of Sciences, National The New York Academy of Sciences, National The Paget Foundation, United States-Israel Binational Science Foundation, University of Pennsylvania School of Medicine Orthopaedic Alumni Assoc.,

Hospital Affiliation

Dr. Kaplan is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Zhang W, Zhang K, Song L, Pang J, Ma H, Shore EM, Kaplan FS, Wang P.: The phenotype and genotype of fibrodysplasia ossificans progressiva in China: A report of 72 cases Bone 57 : 386-391,2013.

Regard JB, Malhotra D, Gvozdanovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.: Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19 : 1505-1512,2013.

Cairns DM, Pignolo RJ, Uchimura T, Brennan TA, Lindborg CM, Xu M. *Kaplan FS, Shore EM, *Zeng L.(*co-senior authors).: Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. , 2013. J Clin Invest 123 : 3624-3633,2013.

Kaplan FS.: The skeleton in the closet. Gene 528: : 7-11,,2013.

Pignolo RJ, Shore EM, Kaplan FS.: Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Emerging Concepts in Pediatric Bone Disease. Pediatric Endocrinology Reviews. 10(S-2): : 437-448,2013.

La Sala LF, Pozzi LM, McAloose D, Kaplan FS, Shore EM, Kompanje EJ, Sidor IF, Musmeci L, Uhart MM.: Severe soft tissue ossification in a southern right whale Eubalanea australis Dis Aquat Organ 102 : 149-156,2012.

Mohler ER, Kaplan FS, Pignolo RJ.: Boning-up on aortic valve calcification. J Am Coll Cardiol 60 : 1954-1955,2012.

Liu JJ, Russell E, Zhang D, Kaplan FS, Pignolo RJ, Shore EM.: Paternally-inherited Gs-alpha mutation impairs adipogenesis and potentiates a lean phenotype in vivo. Stem Cells 30: : 1477-1485,2012.

Hammond P, Suttie M, Hennekam RC, Allanson J, Shore EM, Kaplan FS.: The face signature of fibrodysplasia ossificans progressiva. Am J Med Genet 158A: : 1368-1380,,2012.

Chakkalakal SA, Zhang D, Culbert AL, Convente MR, Caron RJ, Wright AC, Maidment AD, Kaplan FS, Shore EM.: An Acvr1 Knock-in mouse has fibrodysplasia ossificans progressiva. J Bone Miner Res 27: : 746-1756, ,2012.

Academic Contact Info

Penn Medicine University City
Department of Orthopaedic Surgery
3737 Market Street, 6th floor

Philadelphia, PA 19104
Phone: (215) 294-9145
Patient appointments: 800-789-7366 (PENN)

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