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Frederick S. Kaplan, MD

Frederick S. Kaplan, MD Surgeon

Chief, Division of Molecular Orthopaedic Medicine, Department of Orthopaedic Surgery Professor Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine in Orthopaedic Surgery

Dr. Kaplan is employed by Penn Medicine.

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About Dr. Frederick S. Kaplan

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Philadelphia Magazine's Top Docs issues in 2007, 2008,  2012, 2013, and 2018

Clinical Specialties


  • Orthopaedic Surgery

Programs & Centers:

  • Metabolic Bone Disease Services

Clinical Expertise:

  • Fibrodysplasia Ossificans Progressiva (FOP)
  • Heterotopic Ossification (HO)
  • Metabolic Bone Disease
  • Osteomalacia
  • Osteoporosis
  • Paget's Disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: Hospital of the University of Pennsylvania


Academic Orthopaedic Society (AOS), Alpha Omega Alpha, National American Academy of Orthopaedic Surgeons, National American Society for Gravitational and Space Biology, National American Society for Microbiology, Arthritis Foundation, Belgian FOP Association (FOP Belgium), Charles Herndon Orthopaedic Society (2006), National College of Physicians of Philadelphia, College of Physicians of Philadelphia, Edgar L. Ralston Society, European Neuromuscular Center, Federation of American Societies for Experimental Biology, Förderverein für Fibrodysplasia Ossificans Progressiva-Ekrankte (FOPe. V.) Germany, Foundation Program Committee, Greater Philadelphia Philosophy Consortium (1990), International Fibrodysplasia Ossificans Progressiva Association (IFOPA), International International Science Foundation, Intl. Society of Bone & Soft Tissue Densitometry, Johns Hopkins Medical and Surgical Society, Medical Research Council; London, National Cancer Institute of Canada, National Institutes of Health of the United States, National Organization for Rare Disorders, National Osteoporosis Foundation, Orthopaedic Research and Education Foundation (OREF), Orthopaedic Research Society, Phi Beta Kappa, Progressive Osseous Heteroplasia Association (POHA), International Research Advisory Panel, The National Paget's Disease Registry, Swiss National Science Foundation, The Benjamin Franklin Society, The Institute of Medicine of the National Academy of Sciences of the United States, National The John Morgan Society, The Lindback Society, The New York Academy of Sciences, National The New York Academy of Sciences, National The Paget Foundation, United States-Israel Binational Science Foundation, University of Pennsylvania School of Medicine Orthopaedic Alumni Assoc.,

Hospital Affiliation

Dr. Kaplan is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Pignolo RJ, Shore EM, Kaplan FS.: Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Emerging Concepts in Pediatric Bone Disease. Pediatric Endocrinology Reviews. 10(S-2): : 437-448,2013.

Zhang W, Zhang K, Song L, Pang J, Ma H, Shore EM, Kaplan FS, Wang P.: The phenotype and genotype of fibrodysplasia ossificans progressiva in China: A report of 72 cases Bone 57 : 386-391,2013.

Regard JB, Malhotra D, Gvozdanovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.: Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19 : 1505-1512,2013.

Cairns DM, Pignolo RJ, Uchimura T, Brennan TA, Lindborg CM, Xu M. *Kaplan FS, Shore EM, *Zeng L.(*co-senior authors).: Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. , 2013. J Clin Invest 123 : 3624-3633,2013.

Kaplan FS.: The skeleton in the closet. Gene 528: : 7-11,,2013.

Mohler ER, Kaplan FS, Pignolo RJ.: Boning-up on aortic valve calcification. J Am Coll Cardiol 60 : 1954-1955,2012.

Zimmer J, Doelken SC, Horn D, Groppe JC, Shore EM, Kaplan FS, Seemann P.: Functional analysis of alleged NOGGIN Mutation G92E disproves its pathogenic relevance. PLoS One 7 ((4): e35062: ): 1-7,2012.

Kitterman JA, Strober JB, Kan L, Rocke DM, Cali A, Peeper J, Snow J, Delai PLR, Morhart R, Pignolo RJ, Shore EM, Kaplan FS.: Neurological symptoms in individuals with fibrodysplasia ossificans progressiva. J Neurol : 2012.

La Sala LF, Pozzi LM, McAloose D, Kaplan FS, Shore EM, Kompanje EJ, Sidor IF, Musmeci L, Uhart MM.: Severe soft tissue ossification in a southern right whale Eubalanea australis Dis Aquat Organ 102 : 149-156,2012.

Kaplan FS, Chakkalakal SA, Shore EM.: Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis. Dis Model Mech 5 : 756-762,2012.

Academic Contact Info

Penn Medicine University City
Department of Orthopaedic Surgery
3737 Market Street, 6th floor

Philadelphia, PA 19104
Phone: (215) 294-9145
Patient appointments: 800-789-7366 (PENN)

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