Penn Medicine Provider
Orthopaedic Surgery
Frederick S. Kaplan, MD
Sees patients of all ages
Penn Orthopaedics University City - 8th Floor
Make an appointmentCall 800-789-7366

About me

  • Chief, Division of Molecular Orthopaedic Medicine, Department of Orthopaedic Surgery
  • Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine in Orthopaedic Surgery

Dr. Kaplan specializes in research of musculoskeletal disorders such as fibrodysplasia ossificans progressiva (FOP) and progresstive osseous heteroplasia (FOH). 

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized in Philadelphia magazine's annual Top Docs issues, 2007, 2008, 2012, 2013, 2018 - 2020

Education and training

  • Medical School: Johns Hopkins University School of Medicine
  • Residency: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Learn about location

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Kaplan is a Penn Medicine physician.

Qualifications and experience

My research

McCullough M. A crippling disease called FOP is so rare it usually goes undiagnosed. A documentary may change that. , Philadelphia Inquirer.: 2020

Kaplan FS, Shore EM. Fibrodysplasia ossificans progressiva. , National Organization for Rare Disorders.: 2020

Pignolo RJ, Wang H, Kaplan FS. Fibrodysplasia ossificans progressiva: a segmental progeroid syndrome. 10 1-3, 2020 , Frontiers in Endocrinology , 10 (Article 908): 2020,1-3

Kou S, DeCunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, DiRocco M, Keen R, Al Mukaddam M, le Qua Sang K-H, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC. Patients with ACVR1R206H mutations have an increased prevalence of cardiac condition abnormalities on electrocardiogram in a natural history study of fibrodysplasia ossificans progressiva. , Orphanet J Rare Diseases : 2020

Kaplan FS. Kaplan FS, Al Mukaddam M, Stanley A, Towler OW, Shore EM. Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis. , Bone : 2020

Pignolo RJ, Cheung K. Kile S, Fitzpatrick MA, DeCunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff, EMW, DiRocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang K, Kaplan FS. Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association global registry. , Bone: 2020

Pignolo RJ, Kaplan FS. Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva. Expert Opinion on Orphan Drugs. p. 1-9. https://doi.org/10.1080/21678707. 2020.1751122 , Expert Opinion on Orphan Drugs: 2020,1-9

Kaplan FS, Al Mukaddam M, Pignolo RJ. Compartment syndrome of the thigh in a patient with fibrodysplasia ossificans progressiva. , J Ortho Case Reports, 10(3): 2020,103-107

Kaplan FS, Shore EM. Progressive osseous heteroplasia. , National Organization for Rare Disorders.: 2020

Cali A & Schwegler O (Executive Producers). Tin Soldiers. Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; October 5, 2019 , Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; Winner of Hollywood Independent Filmmaker Award.: 2019