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Frank E. Silvestry, MD

Frank E. Silvestry, MD Physician

Associate Chief for Education, Cardiovascular Division Director, Penn Cardiovascular Disease Fellowship Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Silvestry is employed by Penn Medicine.

About Dr. Frank E. Silvestry

Recognized by America's Top Doctors, 2012 - 2018

Recognized by Best Doctors in America 2003 - 2018

Recognized by Main Line Today Top Doctors 2009 issue

Recognized in Philadelphia magazine's annual Top Docs issues, 2002, and 2012 - 2018

Recognized by Suburban Life magazine's "Top Physicians 2010" issue

Recognized in Delaware Valley Consumers' Checkbook 2003 Top Docs issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 1997

Clinical Expertise:

  • 3D Echocardiography
  • Cardiology Risk Intervention
  • Consultative Cardiology
  • Echocardiography
  • Hyperlipidemia (Hyperlipoproteinemia)
  • Interventional Echocardiography
  • Intracardiac Echocardiography (ICE)
  • Ischemic Heart Disease (Myocardial Ischemia)
  • Non-Invasive Cardiac Imaging
  • Patent Foramen Ovale Closure
  • Percutaneous Treatment of Heart Disease
  • Transesophageal Echocardiogram (TEE)

Description of Clinical Expertise

Mitral Valve Disease
Patent Foramen Ovale
Atrial Septal Defect
Intracardiac Echocardiography
Interventional Echocardiography
Valvular heart disease
Preventitive cardiology
Lipid abnormalities
Metabolic syndrome

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Society of Echocardiography, National Fellow, American College of Cardiology (FACC), National Fellow, American Society of Echocardiography (FASE), National

Hospital Affiliation

Dr. Silvestry is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Mitral Valve Disease
Patent Foramen Ovale
Atrial Septal Defect
Structural heart disease
Valvular heart disease
Cardiac Imaging
Intracardiac Echocardiography
Interventional Echocardiography

Selected Publications:

Hirshfeld John W, Fiorilli Paul N, Silvestry Frank E: Important Strategies to Reduce Occupational Radiation Exposure in the Cardiac Catheterization Laboratory: No Lower Limit. Journal of the American College of Cardiology 71 (11): 1255-1258,2018.

Kaye David M, Silvestry Frank E, Gustafsson Finn, Cleland John G, van Veldhuisen Dirk J, Ponikowski Piotr, Komtebedde Jan, Nanayakkara Shane, Burkhoff Dan, Shah Sanjiv J: Impact of atrial fibrillation on rest and exercise haemodynamics in heart failure with mid-range and preserved ejection fraction. European journal of heart failure : 2017.

Kaye David M, Hasenfuß Gerd, Neuzil Petr, Post Martijn C, Doughty Robert, Trochu Jean-Noël, Kolodziej Adam, Westenfeld Ralf, Penicka Martin, Rosenberg Mark, Walton Antony, Muller David, Walters Darren, Hausleiter Jorg, Raake Philip, Petrie Mark C, Bergmann Martin, Jondeau Guillaume, Feldman Ted, Veldhuisen Dirk J van, Ponikowski Piotr, Silvestry Frank E, Burkhoff Dan, Hayward Christopher: One-Year Outcomes After Transcatheter Insertion of an Interatrial Shunt Device for the Management of Heart Failure With Preserved Ejection Fraction. Circulation. Heart failure 9 (12): 2016.

Rene AG, Jagasia D, Wickramasinghe SR, Desai N, Szeto W, Vallabhajosyula P, Li RH, Silvestry FE, Giri J, Jha S, Herrmann HC, Anwaruddin S1: New Ventricular Septal Defects Following Balloon-Expandable Transcatheter Aortic Valve Replacement J Invasive Cardiol 28 (7): E59-65,2016.

Feldman Ted, Komtebedde Jan, Burkhoff Daniel, Massaro Joseph, Maurer Mathew S, Leon Martin B, Kaye David, Silvestry Frank E, Cleland John G F, Kitzman Dalane, Kubo Spencer H, Van Veldhuisen Dirk J, Kleber Franz, Trochu Jean-Noël, Auricchio Angelo, Gustafsson Finn, Hasenfuβ Gerd, Ponikowski Piotr, Filippatos Gerasimos, Mauri Laura, Shah Sanjiv J: Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure: Rationale and Design of the Randomized Trial to REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I). Circulation. Heart failure 9 (7): 2016.

Liang JJ, Silvestry FE.: Mechanistic insights into mitral regurgitation due to atrial fibrillation: "atrial functional mitral regurgitation" Trends Cardiovasc Med : 2016.

Hasenfuß Gerd, Hayward Chris, Burkhoff Dan, Silvestry Frank E, McKenzie Scott, Gustafsson Finn, Malek Filip, Van der Heyden Jan, Lang Irene, Petrie Mark C, Cleland John G F, Leon Martin, Kaye David M: A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial. Lancet (London, England) 387 (10025): 1298-304,2016.

Feldman Ted, Kar Saibal, Elmariah Sammy, Smart Steven C, Trento Alfredo, Siegel Robert J, Apruzzese Patricia, Fail Peter, Rinaldi Michael J, Smalling Richard W, Hermiller James B, Heimansohn David, Gray William A, Grayburn Paul A, Mack Michael J, Lim D Scott, Ailawadi Gorav, Herrmann Howard C, Acker Michael A, Silvestry Frank E, Foster Elyse, Wang Andrew, Glower Donald D, Mauri Laura: Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II. Journal of the American College of Cardiology 66 (25): 2844-54,2015.

Frank E. Silvestry, MD: Primary Mitral Valve Regurgitation Treatment Options American College of Cardiology/ : 2015.

Frank E. Silvestry, MD, FASE, Chair, Meryl S. Cohen, MD, FASE, Co-Chair, Laurie B. Armsby, MD, FSCAI, Nitin J. Burkule, MD, DM, FASE, Craig E. Fleishman, MD, FASE, Ziyad M. Hijazi, MD, MPH, MSCAI, Roberto M. Lang, MD, FASE, Jonathan J. Rome, MD, and Yan Wang, RDCS: Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale: From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions J Am Soc Echocardiogr 28 : 910-58,2015.

View all publications

Academic Contact Info

Cardiovascular Division
Department of Medicine
11-133 South Pavillion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 615-5236
Patient appointments: 800-789-7366 (PENN)

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