Penn Medicine Provider
Pathology and Laboratory Medicine
Frank S. Lee, MD, PhD
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP

About me

  • Professor of Pathology and Laboratory Medicine

My clinical expertise is in medical (autopsy) pathology.

Education and training

  • Medical School: Harvard University
  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
  • Fellowship: Massachusetts General Hospital/Brigham and Women’s Hospital

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Lee is a Penn Medicine physician.

Qualifications and experience

My research

Lee, F.S. Hypoxia Inducible Factor pathway proteins in high-altitude mammals , Trends Biochem. Sci., 49: 2024,79-92


Jorgensen, K.#, Song, D.#, Weinstein, J., Garcia, O.A., Pearson, L.N., Inclan, M., Rivera-Chira, M., Leon-Velarde, F., Kiyamu, M., Brutsaert, T.D., Bigham, A.W.*, and Lee, F.S.* High-Altitude Andean H194R HIF2A Allele is a Hypomorphic Allele. , Mol. Biol. Evol., 40: 2023,msad162


Song D., Peng K., Palmer B.E., & Lee F.S. The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α , EMBO J, 41: 2022,e112059


Song, D., Bigham, A.W., & Lee, F.S. High-altitude deer mouse Hypoxia inducible factor-2α shows defective interaction with CREB-binding protein. , J. Biol. Chem., 296: 2021,100461


Song, D., Navalsky, B.E., Guan, W., Ingersoll, C., Wang, T., Loro, E., Eeles, L., Matchett, K.B., Percy, M.J., Medina, R.J., Khurana, T.S., Bigham, A.W., Lappin, T.R., & Lee, F.S. Tibetan PHD2, an allele with loss of function properties , Proc. Natl. Acad. Sci. USA, 117: 2020,12230-12238


Bigham, A.W., & Lee, F.S. Human high-altitude adaptation: forward genetics meets the HIF pathway , Genes & Dev, 28(20): 2014,2189-2204


Song, D., Li, L.-S., Arsenault, P.R., Tan, Q., Bigham, A.W., Heaton-Johnson, K.J., Master, S.R., & Lee, F.S. Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing , J. Biol. Chem., 289(21): 2014,14656–14665


Percy, M.J., Furlow, P.W., Lucas, G.W., Li, X., Lappin, T.R.J., McMullin, M.F., & Lee, F.S. A gain of function mutation in the HIF2A gene in familial erythrocytosis. , N Engl J Med , 358(2): 2008,162-168


Percy M.J., Zhao Q., Flores A., Harrison C., Lappin T.R., Maxwell P.H., McMullin M.F.*, & Lee F.S.* A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. , Proc Natl Acad Sci U S A, 103(3): 2006,654-659


Yu, F., White, S.B., Zhao, Q., & Lee, F.S. HIF-1α Binding to VHL is Regulated by Stimulus-Sensitive Proline Hydroxylation , Proc. Natl. Acad. Sci. USA, 98(17): 2001,9630-9635


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