Description of Research Expertise:
Dr. Jensen is Professor of Neurology and Chairman of Neurology at the Perelman School of Medicine, University of Pennsylvania, and Co-Director of Penn Translational Neuroscience Center. She was formerly Professor of Neurology, Harvard Medical School, Director of Translational Neuroscience and senior neurologist at Boston Children’s Hospital and Brigham and Women’s Hospital. She is a graduate of Cornell Medical College and obtained her neurology residency training at the Harvard Longwood Neurology Residency Program. Her research focuses on mechanisms of epilepsy and stroke, and the mechanistic interaction of epilepsy with other disorders such as autism and dementia, with specific emphasis on elucidating new therapies for clinical trials development. She received a 2007 Director’s Pioneer Award from the NIH to explore the interaction between epileptogenesis and cognitive dysfunction, and elected as a member of the National Academy of Medicine in 2015. Dr. Jensen was President of the American Epilepsy Society in 2012 and has served on a number of other leadership boards including the Council for the Society for Neuroscience and the Council at NICHD. She currently serves on the Board of the American Neurological Association, the scientific advisory panel at NIH for the BRAIN Initiative, and on a number of charitable foundations for neuroscience research. She has authored over 150 manuscripts on subjects related to her research and has been continuously funded by NIH since 1987. Dr. Jensen has trained numerous clinical and basic research fellows who now hold independent faculty positions nationally and internationally. Dr. Jensen is a Trustee of the Franklin Institute in Philadelphia and is involved in community outreach for brain research and education. In addition, Dr. Jensen is an advocate for awareness of the adolescent brain development, its unique strengths and vulnerabilities, as well as their impact on medical, social, and educational issues unique to teenagers and young adults, and author of the book “The Teenage Brain”, released by Harper Collins in 2015/16, translated and published in over 25 languages worldwide.
Jantzie Lauren L, Talos Delia M, Jackson Michele C, Park Hyun-Kyung, Graham Dionne A, Lechpammer Mirna, Folkerth Rebecca D, Volpe Joseph J, Jensen Frances E: Developmental Expression of N-Methyl-D-Aspartate (NMDA) Receptor Subunits in Human White and Gray Matter: Potential Mechanism of Increased Vulnerability in the Immature Brain. Cerebral cortex (New York, N.Y. : 1991) : 2013.
Engel J Jr, Pitkänen A, Loeb JA, Edward Dudek F, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A.: Epilepsy Biomarkers Epilepsia : 2013.
Pitkänen Asla, Nehlig Astrid, Brooks-Kayal Amy R, Dudek F Edward, Friedman Daniel, Galanopoulou Aristea S, Jensen Frances E, Kaminski Rafal M, Kapur Jaideep, Klitgaard Henrik, Löscher Wolfgang, Mody Istvan, Schmidt Dieter: Issues related to development of antiepileptogenic therapies. Epilepsia 54 Suppl 4 : 35-43,2013.
Brooks-Kayal Amy R, Bath Kevin G, Berg Anne T, Galanopoulou Aristea S, Holmes Gregory L, Jensen Frances E, Kanner Andres M, O'Brien Terence J, Whittemore Vicky H, Winawer Melodie R, Patel Manisha, Scharfman Helen E: Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia 54 Suppl 4 : 44-60,2013.
Wintermark Pia, Lechpammer Mirna, Warfield Simon K, Kosaras Bela, Takeoka Masanori, Poduri Annapurna, Madsen Joseph R, Bergin Ann M, Whalen Stephen, Jensen Frances E: Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. Journal of child neurology : 2013.
Ryan T. Cleary, Hongyu Sun, Thanhthao Huynh, Simon M. Manning, Yijun Li, Alexander Rotenberg, Delia M. Talos, Kristopher T. Kahle, Michele Jackson, Sanjay N. Rakhade, Gerard Berry, Frances E. Jensen: Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures PLOS ONE : 10.1371/journal.pone.0057148,2013.
Jacobs Margaret, Jensen Frances E: Introduction to institute of medicine report: epilepsy across the spectrum: promoting health and understanding. Epilepsy currents / American Epilepsy Society 12 (6): 243-4,2012.
Kowbow K, Auvin S, Jensen F, Loscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkanen A, Nehlig A, Rho JM: Finding a better drug for epilepsy: Antiepileptogenesis Targets Epilepsia : 2012.
Zhou C, Lippman Bell JJ, Sun H, Jensen FE: Learning Through Silence: Amping up Cognition After Neonatal Hypoxic Seizures Through AMPA Receptor Inhibition Journal of Neuroscience : 2012.