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Fiona Simpkins, MD

Fiona Simpkins, MD Physician

Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Dr. Simpkins is employed by Penn Medicine.

Clinical Specialties


  • Gynecologic Oncology

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology - Gynecologic Oncology, 2011
  • Obstetrics and Gynecology, 2009

Clinical Expertise:

  • Cervical Cancer
  • Cervical Dysplasia
  • Cervical Lesions
  • Cervix Biopsy
  • Chemotherapy for Gynecologic Cancers
  • Colposcopy
  • Endometrial Cancer
  • Fallopian Tube Cancer
  • Gynecologic Cancer
  • Gynecologic Cancer Surgery
  • Gynecologic Surgery
  • Gynecology Clinical Trials
  • Hysterectomy (Uterus Surgery)
  • Hysteroscopy
  • Laparoscopic Hysterectomy
  • Laparoscopic Supracervical Hysterectomy
  • Laparoscopy
  • Loop Electrosurgical Excision Procedure (LEEP)
  • Minimally Invasive Hysterectomy
  • Ovarian Cancer
  • Robotic Surgery
  • Trophoblastic Cancer
  • Uterine Cancer
  • Vaginal Cancer
  • Vulvar Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Temple University School of Medicine
Residency: Johns Hopkins Hospital
Fellowship: National Institutes of Health
Fellowship: Cleveland Clinic Foundation


Alpha Omega Alpha Society Member, National American Board of Obstetrics and Gynecology, Exam writer for written boards, National American College of Obstetricians & Gynecologists, Fellow, National Candidate member, American Society of Clinical Oncologists (ASCO), National NRG (Gynecological Oncology Group) Experimental Therapeutics and Phase 1 Committee Member, National Society of Gynecologic Oncology (SGO), National

Hospital Affiliation

Dr. Simpkins is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Hyoung Kim, Veena Jagnnathan, Dorothy Halberg, Haineng Xu, Erin George, Sergey Medvedev, Yasuto Kinose, Anne van Harten, Victor Velculesco, Eric Brown, Fiona Simpkins: Optimizing DDRi combinations by genetic context in ovarian cancers from germline BRCA carriers. Basser Symposium for BRCA : 2019.

Arlene Garcia, Natalie MacKenzie, Margaret Whicker, Joseph Lucci, Matt Pearson, Loraine Portelance, Gordon Mills, Lilie Lin, Fiona Simpkins: Phase I clinical trial of nelfinavir and chemoradiation in locally advanced cervix cancer. SGO, Honolulu, HI : 2019.

Yasuto Kinose, Dorothy Hallberg, Gordon Mills, Tan Ince, Victor Velculescu, Fiona Simpkins, Ronny Drapkin: Comprehensive genomic, proteomic, and experimental characterization of ovarian clear cell carcinoma cell lines for improved drug development 12th Biennial Ovarian Cancer Research Symposium presented by the Rifkin center for Ovarian Cancer and the American Association for Cancer Research, Seattle WA : 2018.

Haineng X, Yasuto Kinose, Hyoung Kim, Sergey Medvedev, Erin George, Ronny Drapkin, Eric Brown, Gordon Mills, Fiona Simpkins: A novel treatment approach for targeting Cyclin E over-expressing ovarian cancers 12th Biennial Ovarian Cancer Research Symposium presented by the Rifkin center for Ovarian Cancer and the American Association for Cancer Research, Seattle WA : 2018.

Hyoung Kim, Erin George, Haineng Xu, Sergey Medvedev, Veena Jagannathan, Mark Morgan, Gordon Mills, Eric Brown, Fiona Simpkins: ATR inhibition targets treatment resistant ovarian cancer 12th Biennial Ovarian Cancer Research Symposium presented by the Rifkin center for Ovarian Cancer and the American Association for Cancer Research, Seattle WA : 2018.

*Simpkins F, Jang K, Yoon H, Hew K, Kim M, Azzam D, Sun J, Zhao D, Ince, T, Liu W, Guo W, Zhi Wei, Zhang G, Mills G, *Slingerland JM: *Co-corresponding authors. Dual Src and MEK inhibition decreases ovarian cancer growth and targets tumor initiating stem-like cells. Clin Cancer Res : 2018.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest : 2018.

George E, Kim H, Ragland R, Butler L, Morgan M, Gilad O, Brown E, Simpkins F: Improving the efficacy of PARP inhibition with a novel ATR inhibitor, ATRN119, in ovarian high grade serous cancers (HGSC). Poster presented at: Society of Gynecologic Oncology, New Orleans, LA, : 2018.

Karakashev S, Zhu H, Yokoyama Y, Zhao B, Fatkhutdinov N, Kossenkov AV, Wilson AJ, Simpkins F, Speicher D, Khabele D, Bitler BG, Zhang R: BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer. Cell Rep 21(12):3398-3405 : 2017.

Garcia-Soto AE, Schreiber T, Strbo N, Ganjei-Azar P, Miao F, Koru-Sengul T, Simpkins F, Nieves-Neira W, Lucci J 3rd, Podack ER: Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors. Gynecol Oncol 145(3):413-419 : 2017.

Academic Contact Info

Jordan Center for Gynecologic Oncology at Penn Perelman Center for Advanced Medicine
3400 Civic Center Blvd., 3rd Floor West

Philadelphia, PA 19104
Phone: (215) 662-3318
Patient appointments: 800-789-7366 (PENN)