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Fiona Simpkins, MD

Fiona Simpkins, MD Physician

Assistant Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Languages spoken:

  • French

Dr. Simpkins is a Penn Medicine employed physician.

Clinical Specialties


  • Obstetrics and Gynecology

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology - Gynecologic Oncology, 2011
  • Obstetrics and Gynecology, 2009

Clinical Expertise:

  • Cervical Cancer
  • Cervical Dysplasia
  • Cervical Lesions
  • Cervix Biopsy
  • Chemotherapy for Gynecologic Cancers
  • Colposcopy
  • Endometrial Cancer
  • Fallopian Tube Cancer
  • Gynecologic Cancer
  • Gynecologic Cancer Surgery
  • Gynecologic Surgery
  • Gynecology Clinical Trials
  • Hysterectomy
  • Hysteroscopy
  • Laparoscopy
  • LEEP Procedure
  • Minimally Invasive Hysterectomy
  • Ovarian Cancer
  • Robotic Surgery
  • Robotic-Assisted Laparoscopic Hysterectomy (RALH)
  • Supracervical Hysterectomy - Laparoscopic
  • Trophoblastic Cancer
  • Uterine Cancer
  • Vaginal Cancer
  • Vulvar Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Temple University School of Medicine
Residency: Johns Hopkins Hospital
Fellowship: National Institutes of Health
Fellowship: Cleveland Clinic Foundation


Alpha Omega Alpha Society Member, National American College of Obstetricians & Gynecologists, National Candidate member, American Society of Clinical Oncologists (ASCO), National NRG (Gynecological Oncology Group) Experimental Therapeutics Committee Member, National Society of Gynecologic Oncology (SGO), National

Hospital Affiliation

Dr. Simpkins is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Hew KE, Miller PC, El-Ashry D, Sun J, Besser AH, Ince TA, Gu M, Wei Z, Zhang G, Brafford P, Gao W, Lu Y, Mills GB, Slingerland JM, Simpkins F: MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer. Clin Cancer Res 22(4):935-47 : 2016.

George E, Kim H, Tanyi J, Ragland R, Brown E, Zhang R, Brafford P, Sproesser K, Beqiri M, Vultur A, Krepler C, Lee R, Weis B, Nathanson K, Lu Y, Mills G, Makvandi M, Mach R, Morgan M, Herlyn M, Simpkins F: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers. Poster, AACR, New Orleans, LA, : 2016.

Zhang X, Haggerty AF, Brown JC, Giuntoli R 2nd, Lin L, Simpkins F, Dean LT, Ko E, Morgan MA, Schmitz KH: The prescription or proscription of exercise in endometrial cancer care. Gynecol Oncol 139(1):155-9 : 2015.

Kim H, George E, Brown E, Zhang R, Krepler C, Tanyi J, Lee R, Morgan MA, Herlyn M, Simpkins, F: Targeting the ATR/CHK1 axis in BRCA1/2 mutant ovarian cancer using an orthotopic patient-derived xenograft (PDX) model. Poster, AACR, Orlando, FL, : 2015.

Chen J, Solomides C, Parekh H, Simpkins F, Simpkins H: Cisplatin resistance in human cervical, ovarian and lung cancer cells. Cancer Chemother Pharmacol 75(6):1217-27 : 2015.

Garcia-Soto A, McKenzie N, Portelance L, Castillo R, Pearson M, Hu J, Lucci JA 3rd, Lin L, Simpkins F: Phase I trial of nelfinavir added to cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer. Poster and published for ASCO. J Clin Oncol 33 (suppl; abstr TPS5619) : 2015.

Simpkins F, Drake R, Escobar PF, Nutter B, Rasool N2, Rose PG: A phase II trial of paclitaxel, carboplatin, and bevacizumab in advanced and recurrent endometrial carcinoma (EMCA). Gynecol Oncol 136(2):240-5 : 2015.

Cui H, He Y, Krepler C, Tanyi J, Morgan MA, Burger RA, Kim S, Ko E, Ince T, Herlyn M, Simpkins F: A true orthotopic ovarian cancer patient-derived xenograft (PDX) model. Poster and published for AACR, Philadelphia, PA, Cancer Res 75; 3223 : 2015.

Hew K, Miller P, Sun J, Wei Z, Zhang G, Lu Y, Mills G, Slingerland J, El-Ashry D, Simpkins F: MEK inhibition reverses antiestrogen resistance in ovarian cancer (OVCA) via alteration of cell cycle pathways and MAPK/estrogen regulated gene expression. Oral presentation and published, AACR Meeting, Marsha Rivkin Center for Ovarian Cancer Research Symposia, Seattle WA Clin Cancer Res 21; AS31 : 2014.

Simpkins F, Hew K, Azzam D, Wei Z, Zhang G, Sun J, Zhang D, Jang K, Liu W, Lu Y, Mills G, Tan I, Slingerland J: Combined Src and MEK inhibition decreases ovarian cancer (OVCA) cell growth, tumorigenicity and aldehyde dehydrogenase positive tumor-initiating-cells. Poster and published for the AACR Meeting, Marsha Rivkin Center for Ovarian Cancer Research Symposia, Seattle WA, Clin Cancer Res 21; POSTER-THER-1431 : 2014.

Academic Contact Info

Jordan Center for Gynecologic Oncology at Penn Perelman Center for Advanced Medicine
3400 Civic Center Blvd., 3rd Floor West

Philadelphia, PA 19104
Phone: (215) 662-3318
Fax: (215) 349-5849
Patient appointments: 800-789-PENN (7366)