Description of Research Expertise:
The Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.
Mark H. O’Hara, Eileen O’Reilly, Rosemarie Mick, Gauri Varadhachary, Zev Wainberg, Andrew Ko, George Fisher, Osama Rahma, Jaclyn P. Lyman, Christopher R. Cabanski, Erica L. Carpenter, Travis Hollmann, Pier F. Gherardini, Lacey Kitch, Cheryl Selinsky, Theresa LaVallee, Ovid C. Trifan, Ute Dugan, Vanessa Lucey, Robert H. Vonderheide: A Phase 1b Study of CD40 Agonistic Monoclonal Antibody APX005M Together with Gemcitabine (Gem) and nab-Paclitaxel (NP) with or without Nivolumab (Nivo) in Untreated Metastatic Ductal Pancreatic Adenocarcinoma (PDAC) Patients American Association of Cancer Research General Meeting : 2019.
Ling Wang, Lynn Godfrey, Maria Krevvata, Keely Dulmage, Cathy Spargo, Liping Yu, Silin Sa, Frances Tong, Erica Carpenter, Alfred Garfall, and Eric Dixon: Applying novel technologies to develop a sensitive liquid biopsy for transcriptomic single-cell profiling of circulating multiple myeloma cells AGBT General Meeting : 2019.
Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan Joseph Melenhorst, Ronnie Sebro, Michael Farwell, Wei-Ting Hwang, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas: A Phase 1 Clinical Trial of PSMA-directed/TGFβ-insensitive CAR-T cells in Metastatic Castration-Resistant Prostate Cancer American Society of Clinical Oncologists Genitourinary Cancers Symposium : 2019.
Mark H. O’Hara, Eileen O’Reilly, *, Rosemarie Mick, Gauri Varadhachary, Zev Wainberg, Andrew Ko, George Fisher, Osama Rahma, Erica L. Carpenter, Jaclyn P. Lyman, Christopher R. Cabanski, Ovid C. Trifan, Ute Dugan, Vanessa Lucey, Robert H. Vonderheide: A Phase 1b Study of CD40 Agonistic Monoclonal Antibody APX005M Together with Gemcitabine and nab-Paclitaxel with or without Nivolumab in Untreated Metastatic Ductal Pancreatic Adenocarcinoma (PDAC) Patients American Society for Clinical Oncology Gastrointestinal Cancers Symposium : 2019.
Kim Anna Reiss, Edgar Ben-Josef, Nevena Damjanov, Maarouf Hoteit, Thomas Benjamin Karasic, Erica Carpenter, Lisa DiCicco, Luis Anna Garcia-Marcano, Rosemarie Mick, Robert H Vonderheide: A Pilot Study of Galunisertib (LY2157299) Plus Stereotactic Body Radiotherapy (SBRT) in Advanced Hepatocellular Carcinoma (HCC) American Society of Clinical Oncologists Gastrointestinal Cancers Symposium : 2019.
Stephen J. Bagley, Jacob E. Till, Jazmine Mays, Seyed Ali Nabavizadeh, Stephanie S. Yee, Scott S. Levy, Arati S. Desai, and Erica L. Carpenter: Plasma cell-free DNA (cfDNA) concentration is independently associated with radiographic tumor burden in newly diagnosed glioblastoma (GBM) prior to initial surgical resection Society for Neuro-Oncology : 2018.
Stephen J. Bagley, Jacob E. Till, Jazmine Mays, Seyed Ali Nabavizadeh, Stephanie S. Yee, Scott S. Levy, Arati S. Desai, and Erica L. Carpenter: Plasma Cell-free DNA (cfDNA) Concentration Is Independently Associated with Radiographic Tumor Burden in Newly Diagnosed Glioblastoma (GBM) Prior to Initial Surgical Resection Society for Neuro-Oncology Annual Scientific Meeting : 2018.
Moen Sen, Neha Bhagwat, Keely Dulmage, Sindhushree Raghunandan, Charles H. Pletcher, Jr, Ling Wang, William J. Murphy, William DeMuth, David Balli, Stephanie S. Yee, Silin Sa, Frances Tong, Liping Yu, Jonni S. Moore, Eric P. Dixon, Ben Z. Stanger, Erica L. Carpenter: A novel biomarker panel detects pancreatic ductal adenocarcinoma circulating tumor cells Biomedical Postdoctoral Research Symposium : 2018.
Charu Aggarwal, MD, MPH; Jeffrey C. Thompson, MD; Taylor A. Black, BA; Sharyn I. Katz, MD, MTR; Ryan Fan, BA;, Stephanie S. Yee, MS; Austin L. Chien, BA; Tracey L. Evans, MD; Joshua M. Bauml, MD; EvanW. Alley, MD, PhD;, Christine A. Ciunci, MD, MSCE; Abigail T. Berman, MD, MSCE; Roger B. Cohen, MD; David B. Lieberman, MS, LCGC;, Krishna S. Majmundar, BS; Samantha L. Savitch, BA; Jennifer J. D. Morrissette, PhD;Wei-Ting Hwang, PhD;, Kojo S. J. Elenitoba-Johnson, MD; Corey J. Langer, MD; Erica L. Carpenter: Clinical implications of plasma-based genotyping with the delivery of personalized therapy in metastatic non-small cell lung cancer JAMA Oncology in press : 2018.
Melina Marmarelis*, Erin Bange*, Stephen Bagley, Wei-Ting Hwang, Yu-Xiao Yang, Jeffrey Thompson, Joshua Bauml, Christine Ciunci, Evan Alley, Jennifer Morrissette, Roger B. Cohen, Corey Langer, Erica Carpenter, Charu Aggarwal: Impact of STK11 co-mutation on outcomes following immunotherapy among patients with TP53 and KRAS mutated stage IV NSCLC World Lung : 2018.