Description of Research Expertise:
The Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.
Neha Bhagwat, Keely Dulmage, Charles H. Pletcher Jr., Ling Wang, William DeMuth, Moen Sen, David Balli, Stephanie S. Yee, Silin Sa, Frances Tong, Liping Yu, Jonni S. Moore, Ben Z. Stanger, Eric P. Dixon & Erica L. Carpenter: An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters Scientific Reports : 2018.
Melina Marmarelis*, Erin Bange*, Stephen Bagley, Wei-Ting Hwang, Yu-Xiao Yang, Jeffrey Thompson, Joshua Bauml, Christine Ciunci, Evan Alley, Jennifer Morrissette, Roger B. Cohen, Corey Langer, Erica Carpenter, Charu Aggarwal: Impact of STK11 co-mutation on outcomes following immunotherapy among patients with TP53 and KRAS mutated stage IV NSCLC International Association for the Study of Lung Cancer : 2018.
Stephen Joseph Bagley, Jazmine Mays, Seyed Ali Nabavizadeh, Stephanie S. Yee, Scott S Levy, Arati Suvas Desai, Erica L. Carpenter: Plasma cell-free DNA (cfDNA) Concentration and Radiographic Tumor Burden in Patents with Glioblastoma (GBM). ASCO General Meeting : 2018.
Jina Ko, Neha Bhagwat, Taylor Black, Stephanie Yee, Young-Ji Na, Stephen Fisher, Junhyong Kim, Erica Carpenter, Ben Stanger, and David Issadore: miRNA Profiling of Magnetic Nanopore Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Cancer Research : 2018.
Moen Sen, Neha Bhagwat, Keely Dulmage, Sindhushree Raghunandan, Charles H. Pletcher, Jr, Ling Wang, William J. Murphy, William DeMuth, David Balli, Stephanie S. Yee, Silin Sa, Frances Tong, Liping Yu, Jonni S. Moore, Ben Z. Stanger, Eric P. Dixon, Erica L. Carpenter: Development of a novel biomarker panel to detect pancreatic ductal adenocarcinoma circulating tumor cells AACR Pancreatic Cancer Meeting : 2018.
Stephen J. Bagley, Jacob E. Till, Jazmine Mays, Seyed Ali Nabavizadeh, Stephanie S. Yee, Scott S. Levy, Arati S. Desai, and Erica L. Carpenter: Plasma cell-free DNA (cfDNA) concentration is independently associated with radiographic tumor burden in newly diagnosed glioblastoma (GBM) prior to initial surgical resection Society for Neuro-Oncology : 2018.
Erin Bange*, Melina Marmarelis*, Wei-Ting Hwang, Yu-Xiao Yang, Jeffrey Thompson, Joshua Bauml, Christine Ciunci, Evan Alley, Tracey Evans, Jennifer Morrissette, Roger B. Cohen, Corey Langer, Erica Carpenter, Charu Aggarwal: Impact of KRAS and TP53 co-mutations on outcomes following 1st-line therapy among patients with LKB1/STK11 mutated stage IV NSCLC AACR General Meeting : 2018.
William Chapin, MD; Kim Reiss-Binder, MD; Mark O’Hara, MD; Erica Carpenter, PhD: Presence of circulating tumor cells detected by immunohistochemical staining and bioinformatics approach associated with worse overall survival in locally advanced and metastatic pancreatic cancer cohorts and may serve as marker of response to therapy University of Pennsylvania School of Medicine Research Day : 2018.
Jacob Till, Prince Addai, Neha Bhagwat, Stephanie Yee, Erica Carpenter, Sam Yoon, Sandra Ryeom: A new mouse model of gastric adenocarcinoma: a valuable tool for preclinical studies AACR general meeting : 2018.
Charu Aggarwal, MD, Christiana W. Davis, MD, Rosemarie Mick MS, Jeffrey C. Thompson, MD, Saman Ahmed, MD, Seth Jeffries, BS, Stephen Bagley, MD, Peter Gabriel, MD, Tracey L. Evans, MD, Joshua M. Bauml, MD, Christine Ciunci, MD, Evan Alley, MD, Jennifer J. D. Morrissette, PhD, Roger B. Cohen, MD, Erica L. Carpenter, MBA, PhD and Corey J. Langer, MD: Influence of TP53 Mutation on Survival and Transformation to Small Cell Lung Cancer in Patients with Advanced EGFR-Mutant Non-small Cell Lung Cancer Journal of Clinical Oncology Precision Medicine : 2018.