Description of Research Expertise
Neuronal autoantibodies, encephalitis, acquired neuromyotonia (Isaacs' syndrome), peripheral nerve hyperexcitability, potassium channels, the glycine receptor, the GABA-B receptor, neuromuscular disorders, stiff person syndrome.
Selected Publications
Argent L, Winter F, Prickett I, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EBE.: Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology Journal of Biological Chemistry 295 (36): 12716-12726,2020.
Tizazu E, Ellis CA, Reichert J, Lancaster E.: Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy Seizure 80 : 38-41,2020.
Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH.: CRISPR-engineered T cells in patients with refractory cancer Science 367 (6481): eaba7365,2020.
Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F.: An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models Lancet Neurology 18 (11): 1045-1057,2019.
Gill A, Perez MA, Perrone CM, Bae CJ, Pruitt AA, Lancaster E.: A case series of PD-1 inhibitor-associated paraneoplastic neurologic syndromes J Neuroimmunol. 334 : 576980,2019.
Lancaster E.: Encephalitis, severe seizures, and multifocal brain lesions: Recognizing autoimmunity to the GABAA receptor. Neurol Neuroimmunol Neuroinflamm. 6 (3): 554,2019.
Lancaster E, Burnor E, Zhang J, Lancaster E.: ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents. Neurosci Lett. (704): 159-163,2019.
Cohen AD, Garfall AL, Stadtmauer EA, Melenhorst JJ, Lacey SF, Lancaster E, Vogl DT, Weiss BM, Dengel K, Nelson A, Plesa G, Chen F, Davis MM, Hwang WT, Young RM, Brogdon JL, Isaacs R, Pruteanu-Malinici I, Siegel DL, Levine BL, June CH, Milone MC.: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. J Clin Invest. (130): 126397,2019.
Patterson K, Iglesias E, Nasrallah M, González-Álvarez V, Suñol M, Anton J, Saiz A, Lancaster E, Armangue T.: Anti-MOG encephalitis mimicking small vessel CNS vasculitis. Neurol Neuroimmunol Neuroinflamm. 6 (2): e538,2019.
Amado DA, Rieders JM, Diatta F, Hernandez-Con P, Singer A, Mak JT, Zhang J, Lancaster E, Davidson BL, Chen-Plotkin AS.: AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity. Mol Ther. 27 (2): 465-478,2019.
Academic Contact Information
3 W. Gates - Neurology
3400 Spruce St.
Philadelphia,
PA
19104
Patient appointments: 800-789-7366