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Elizabeth S. McDonald, MD

Elizabeth S. McDonald, MD Physician

Program Director, Breast/Women's Imaging Fellowship Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

Dr. McDonald is employed by Penn Medicine.

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Clinical Specialties


  • Radiology

Programs & Centers:

Board Certification:

  • Diagnostic Radiology, 2008

Clinical Expertise:

  • Aspiration
  • Biopsy
  • CT Scan (Computed Tomography)
  • Diagnostic Imaging
  • Diagnostic Test
  • Mammogram
  • MRI (Magnetic Resonance Imaging)
  • MRI Guided Biopsy
  • Nuclear Imaging
  • Ultrasound
  • Ultrasound Guided Biopsy

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program
  • Vibra Health Plan

Education and Training

Medical School: Mayo Medical School
Residency: Mayo Clinic
Fellowship: Mayo Clinic
Fellowship: University of Washington Hospital and Clinics


Abramson Cancer Center of the University of Pennsylvania, Local American Association for Cancer Research, National American Roentgen Ray Society, National Breast Cancer Alliance, National Congressionally Directed Medical Research, International Institute for Translational Medicine and Therapeutics, Local Radiological Society of North America, National Society of Breast Imaging, National The Doctor's Mayo Society of the Mayo Clinic Alumni Association, National

Hospital Affiliation

Dr. McDonald is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

McDonald, ES, Doot, RK, Young, AJ, Shubert, ES, Tchou, J, Pyrma, DA, Farwell, MD, Nayak, A, Ziober, A, Feldman, MD, DeMichele, A, Clark, AS, Shah, PD, Lee, H, Carlin, SD, Mach, RH, Mankoff, DA.: Uptake of the Sigma-2 Receptor Ligand, [18F]ISO-1, Correlates with Cell Proliferation Measures in Breast Cancer Journal of Nuclear Medicine : 2019.

McDonald ES, Ulaner GA.: Uses and Opportunities for Molecular Imaging in Patients with Breast Cancer. PET Clin. 2018 Jul;13(3):xi-xii. : 2018.

Rahbar H, Zhang Z, Chenevert TL, Romanoff J, Kitsch AE, Hanna LG, Harvey SM, Moy L, DeMartini WB, Dogan B, Yang WT, Wang LC, Joe BN, Oh KY, Neal CH, McDonald ES, Schnall MD, Lehman CD, Comstock CE, Partridge SC.: Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702). Clin Cancer Res. 25 : 1756-1765,2019.

Chong A, Weinstein SP, McDonald ES, Conant EF.: Digital Breast Tomosynthesis: Concepts and Clinical Practice. Radiology 292 : 1-14,2019.

Korhonen KE, Conant EF, Cohen EA, Synnestvedt M, McDonald ES, Weinstein SP.: Breast Cancer Conspicuity on Simultaneously Acquired Digital Mammographic Images versus Digital Breast Tomosynthesis Images. Radiology 292 : 69-76,2019.

Jessica Hsu, Brianna Moon, Joel stein; Kristen Lau, Mcdonald, Elizabeth, Peter Chhour, Pratap Naha, Maidment, Andrew, Renee Hastings, david cormode, Witschey, Walter: An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging Nanoscale 10 : 17236-17248,2018.

Michael N. Mirzabeigi, M.D.1, Irfan A. Rhemtulla, M.D., M.S.1, Fabiola A. Enriquez, B.A.1, Elizabeth S. McDonald, M.D.2, Dahlia M. Sataloff, M.D.3, Stephen J. Kovach, M.D.1, Liza C. Wu, M.D.1, Joseph M. Serletti, M.D.1, Suhail Kanchwala, M.D.: Locoregional Cancer Recurrence after Breast Reconstruction: Detection, Management, and Secondary Reconstructive Strategies Plastic and Reconstructive Surgery 143 : 1322-1330,2019.

Zeng C, McDonald ES, Mach RH: Molecular probes for imaging the sigma-2 receptor: In vitro and in vivo imaging studies Handb Exp Pharmacol : 2017.

Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW.: Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: Chemical shift artifact of the third kind. Magn Reson Med. 2018 Apr;79(4):2277-2289. : 2018.

So A, De La Cruz LM, Williams AD, Bahng J, Liao G, McDonald ES, Fisher CS, Czerniecki BJ, Sataloff D, Tchou J.: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. J Surg Oncol. 117 (4): 558-566,2018.

Elmi A, McDonald ES, Mankoff D.: Imaging Tumor Proliferation in Breast Cancer: Current Update on Predictive Imaging Biomarkers. PET Clin. 2018 Jul;13(3):445-457. : 2018.

McDonald ES, McCarthy AM, Weinstein SP, Schnall MD, Conant EF: BI-RADS category 3 comparison: probably benign category after recall from screening before and after implementation of digital breast tomosynthesis Radiology. 2017 Dec;285(3):778-787. : 2017.

McDonald ES, Oustimov A, Weinstein SP, Synnestvedt M, Schnall MD, Conant EF: Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening JAMA Oncology 2 (6): 737-743,2016.

Lowenfeld, L., Zaheer, S., Oechsle, C, Fracol, M., Datta, J, Xu, S, Fitzpatrick, E, Roses, RE, Fisher, CS, McDonald, ES, Zhang, PJ, DeMichele, A, Mick, R., Koski, GK, Czerniecki, BJ.: Addition of anti-estrogen therapy to anti-HER2 dendritic cell vaccination improves regional nodal immune response and pathologic complete response rate in patients with ERpos/HER2pos early breast cancer OncoImmunology : 2017.

Zuckerman SP, Maidment ADA, Weinstein SP, McDonald ES, Conant EF: Imaging with synthesized 2D mammography: differences, advantages, and pitfalls compared with digital mammography AJR Am J Roentgenol 209 (1): 222-229,2017.

McDonald ES, Mankoff D, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death cancer cells Biochem Biophys Res Commun 486 (3): 788-795,2017.

Conant EF, Keller BM, Pantalone L, Gastounioti A, McDonald ES, Kontos D: Agreement between breast percentage density estimations from standard-dose versus synthetic digital mammograms: Results from a large screening cohort using automated measures Radiology Jun;283(3):673-680 : 2017.

Cruz, L, McDonald, ES, Mick, R, Czerneicki, B: Anti-HER2 Th1 Response is Superior to Breast MRI in Response to Neoadjuvant Chemotherapy in Patients with HER2 Positive Breast Cancer Ann Surg Oncol 24 (4): 1057-1063,2017.

Chudgar, AV, Conant, EF, Weinstein, SP, Keller, BM, Synnestvedt, M, Yamartino, P, McDonald, ES: Digital Breast Tomosynthesis versus Digital Mammography alone Screen Detected Breast Cancers: Assessment of Disease Extent on Contrast-enhanced Magnetic Resonance Imaging. Clinical Radiology S0009-9260 (17): 30078-8,2017.

Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES, Maidment AD, Cormode DP: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8 (28): 13740-54,2016.

Makvandi, M, Xu, K, Lieberman, BP, Anderson, R, Effron, SS, Winters, H, Zeng, C, McDonald, ES, Pryma, DA, Greenberg, RA, Mach, RH.: A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research 76 (15): 4516-24,2016.

Zuckerman S,Conant EF,Keller B,Weinstein S,McDonald ES.: Implementation of synthesized 2D mammography in a population-based digital breast tomosynthesis screening program Radiology 28 (1): 730-736,2016.

McDonald ES, Mankoff DA, Mach RH: Novel strategies for breast cancer imaging: new imaging agents to guide treatment J Nuc Med 57 : 69S-74S,2016.

Pertuz S, McDonald ES, Weinstein SP, Conant EC, Kontos D: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging Radiology 279 (1): 65-74,2016.

Mitsumori LM, McDonald ES, Neligan PC, Maki JH: Peripheral Magnetic Resonance Lymphangiography: Techniques and Applications Tech Vasc Inter Radiol 19 (4): 262-272,2016.

Korhonen KE, Weinstein SP, McDonald ES, Conant EF: Strategies to increase cancer detection: Review of true-positive and false-negative results at digital breast tomosynthesis screening Radiographics 36 (7): 1954-1965,2016.

McDonald ES, Hammersley JA, Chou SS, Rahbar H, Scheel JR, Lee CI, Liu CL, Lehman CD, Partridge SC.: Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women with Dense Breasts. AJR Am Journal of Roentgenol 207 (1): 205-16,2016.

Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D: The Impact of acquisition dose on quantitative breast density estimation with digital mammography: Results from ACRIN PA 4006 Radiology 280 (3): 693-700,2016.

McDonald ES, Clark A, Tchou J, Zhang, P, Freedman, G.: Clinical diagnosis and management of breast cancer J Nuc Med 57 : 9S-16S,2016.

Rahbar, H, McDonald, ES, Lee, JM, Partridge, SC, Lee, CI.: How Can Advanced Imaging Be Used to Mitigate Potential Breast Cancer Overdiagnosis? Academic Radiology 23 (6): 768-73,2016.

McDonald ES, McCarthy AM, Akhtar A, Synnestvedt A, Schnall M, Conant EF: Baseline screening mammography: Performance of full field digital versus digital breast tomosynthesis American Journal of Roentgenology 205 (5): 1143-8,2015.

Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA, Mach RH: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer Biochem Biophys Res Commun (BBRC) 467 (4): 1070-1075.,2015.

Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH: MR Lymphangiography: How I do it J Magn Reson Imaging 42 (6): 1465-77,2015.

Clark AS, McDonald E, Lynch MC, Mankoff D: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer Oncology 28 (5): 424-30,2014.

Doot RK, McDonald ES, Mankoff DA: Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials Clin Transl Imaging 2 (4): 295-303,2014.

McDonald ES, Schopp JG, Peacock S, DeMartini WB, Rahbar H, Lehman CD, Partridge SC: Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T AJR Am J Roentgenol 202 (5): W496-502,2014.

Mirzabeigi MN, McDonald ES, Chu MW, Fischer JP, Basta M, Kovach S, Wu LC, Serletti J, Kanchwala S: Operative management of locoregional cancer recurrence following post-mastectomy breast reconstruction-indications and outcomes American Society for Reconstructive Microsurgery : 2016.

Partridge SC, McDonald ES: Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications Magn Reson Imaging Clin N Am 21 (3): 601-624,2013.

Academic Contact Info

Hospital of the University of Pennsylvania
3400 Spruce Street, 1 Silverstein

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)