Description of Research Expertise:
Myeloproliferative Disorders
Umbilical Cord Blood Transplantation
Selected Publications:
Gupta, V., Harrison, C., Hexner, E. O., Al-Ali, H. K., Foltz, L., Montgomery, M., Sun, W., Gopalakrishna, P., Kantarjian, H., Verstovsek, S.: The impact of anemia on overall survival in patients with myelofibrosis treated with ruxolitinib in the COMFORT studies Haematologica : 2016.
Yam, C., Crisalli, L., Luger, S. M., Loren, A. W., Hexner, E. O., Frey, N. V., Mangan, J. K., Gao, A., Stadtmauer, E. A., Porter, D. L., Reshef, R.: Unrelated donors are associated with improved relapse free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem-cell transplantation Am J Hematol 91 (9): 883-7,2016.
Hexner, E. O., Luger, S. M., Reshef, R., Jeschke, G. R., Mangan, J. K., Frey, N. V., Frank, D. M., Richman, L. P., Vonderheide, R. H., Aqui, N. A., Rosenbach, M., Zhang, Y., Chew, A., Loren, A. W., Stadtmauer, E. A., Levine, B. L., June, C. H., Emerson, S. G., Porter, D. L.: Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment Am J Hematol 91 (5): 453-60,2016.
Ganetsky, A., Shah, A., Miano, T. A., Hwang, W. T., He, J., Loren, A. W., Hexner, E. O., Frey, N. V., Porter, D. L., Reshef, R.: Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation Bone Marrow Transplant 51 (4): 568-72,2016.
Meng, L., Bai, Z., He, S., Mochizuki, K., Liu, Y., Purushe, J., Sun, H., Wang, J., Yagita, H., Mineishi, S., Fung, H., Yanik, G. A., Caricchio, R., Fan, X., Crisalli, L. M., Hexner, E. O., Reshef, R., Zhang, Y., Zhang, Y.: The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation J Immunol 196 (3): 1070-80,2016.
Lewen, M., Gresh, R., Queenan, M., Paessler, M., Pillai, V., Hexner, E., Frank, D., Bagg, A., Aplenc, R., Caywood, E., Wertheim, G.: Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report Biomark Res 4 : 14,2016.
Gotlib, J., Kluin-Nelemans, H. C., George, T. I., Akin, C., Sotlar, K., Hermine, O., Awan, F. T., Hexner, E., Mauro, M. J., Sternberg, D. W., Villeneuve, M., Huntsman Labed, A., Stanek, E. J., Hartmann, K., Horny, H. P., Valent, P., Reiter, A.: Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis N Engl J Med 374 (26): 2530-41,2016.
Kumar, A. J., Vassilev, P., Loren, A. W., Luger, S. M., Reshef, R., Gill, S., Smith, J., Goldstein, S. C., Hexner, E., Stadtmauer, E. A., Porter, D., Frey, N. V.: Time to unrelated donor leukocyte infusion is longer, but incidence of GVHD and overall survival are similar for recipients of unrelated DLI compared to matched sibling DLI Am J Hematol 91 (4): 426-9,2016.
Orlowski R, Huang A, Gohil M, Mangan J, Vignali M, Emerson R, Robins H, Yusko E, Jordan M, Carroll M, Gilliland DG, Hexner E: Integrated Immunological Analysis of the Bone Marrow Tumor Microenvironment in Myeloproliferative Neoplasms to Determine Potential Efficacy of Immune Checkpoint Blockade Blood 126 (2766): 2015.
Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Raza, A., Vaddi, K., Sun, W., Peng, W., Sandor, V., Kantarjian, H.: Three-year efficacy, overall survival, and safety of ruxolitinib therapy in patients with myelofibrosis from the COMFORT-I study Haematologica 100 (9): 1139-45,2015.