Description of Research Expertise:
Myeloproliferative Disorders
Umbilical Cord Blood Transplantation
Selected Publications:
Huang, Q., He, S., Tian, Y., Gu, Y., Chen, P., Li, C., Huang, J., Liu, Y., Yu, H., Jin, M., Hu, S., Tong, Q., Ma, A., Jin, J., Hexner, E., Fung, H., Reshef, R., Zhang, Y., Zhang, Y.: Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice Blood : 2017.
Verstovsek, S., Mesa, R. A., Gotlib, J., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Jr., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Paquette, R., Raza, A., Jones, M., Kornacki, D., Sun, K., Kantarjian, H., Comfort- I. investigators: Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial J Hematol Oncol 10 (1): 55,2017.
Hartwell, M. J., Ozbek, U., Holler, E., Renteria, A. S., Major-Monfried, H., Reddy, P., Aziz, M., Hogan, W. J., Ayuk, F., Efebera, Y. A., Hexner, E. O., Bunworasate, U., Qayed, M., Ordemann, R., Wolfl, M., Mielke, S., Pawarode, A., Chen, Y. B., Devine, S., Harris, A. C., Jagasia, M., Kitko, C. L., Litzow, M. R., Kroger, N., Locatelli, F., Morales, G., Nakamura, R., Reshef, R., Rosler, W., Weber, D., Wudhikarn, K., Yanik, G. A., Levine, J. E., Ferrara, J. L.: An early-biomarker algorithm predicts lethal graft-versus-host disease and survival JCI Insight 2 (3): e89798,2017.
Gupta, V., Harrison, C., Hexner, E. O., Al-Ali, H. K., Foltz, L., Montgomery, M., Sun, W., Gopalakrishna, P., Kantarjian, H., Verstovsek, S.: The impact of anemia on overall survival in patients with myelofibrosis treated with ruxolitinib in the COMFORT studies Haematologica 101 (12): e482-e484,2016.
Holtan, S. G., Khera, N., Levine, J. E., Chai, X., Storer, B., Liu, H. D., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Flowers, M. E., Cutler, C. S., Lukez, A., Arai, S., Lazaryan, A., Newell, L. F., Krupski, C., Jagasia, M. H., Pusic, I., Wood, W., Renteria, A. S., Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Watanaboonyongcharoen, P., Efebera, Y. A., Ferrara, J. L., Panoskaltsis-Mortari, A., Weisdorf, D., Lee, S. J., Pidala, J.: Late acute graft versus host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors Blood : 2016.
Yam, C., Crisalli, L., Luger, S. M., Loren, A. W., Hexner, E. O., Frey, N. V., Mangan, J. K., Gao, A., Stadtmauer, E. A., Porter, D. L., Reshef, R.: Unrelated donors are associated with improved relapse free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem-cell transplantation Am J Hematol 91 (9): 883-7,2016.
Hexner, E. O., Luger, S. M., Reshef, R., Jeschke, G. R., Mangan, J. K., Frey, N. V., Frank, D. M., Richman, L. P., Vonderheide, R. H., Aqui, N. A., Rosenbach, M., Zhang, Y., Chew, A., Loren, A. W., Stadtmauer, E. A., Levine, B. L., June, C. H., Emerson, S. G., Porter, D. L.: Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment Am J Hematol 91 (5): 453-60,2016.
Ganetsky, A., Shah, A., Miano, T. A., Hwang, W. T., He, J., Loren, A. W., Hexner, E. O., Frey, N. V., Porter, D. L., Reshef, R.: Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation Bone Marrow Transplant 51 (4): 568-72,2016.
Meng, L., Bai, Z., He, S., Mochizuki, K., Liu, Y., Purushe, J., Sun, H., Wang, J., Yagita, H., Mineishi, S., Fung, H., Yanik, G. A., Caricchio, R., Fan, X., Crisalli, L. M., Hexner, E. O., Reshef, R., Zhang, Y., Zhang, Y.: The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation J Immunol 196 (3): 1070-80,2016.
Lewen, M., Gresh, R., Queenan, M., Paessler, M., Pillai, V., Hexner, E., Frank, D., Bagg, A., Aplenc, R., Caywood, E., Wertheim, G.: Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report Biomark Res 4 : 14,2016.