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Edward B. Lee, MD, PhD Physician

Assistant Professor of Pathology and Laboratory Medicine

Dr. Lee is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 2009
  • Pathology - Neuropathology, 2009

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association of Neuropathologists, National American Board of Pathology, National American Society for Investigative Pathology, National Medical Research Council, International MND Association, International NIH Study Section, National Society for Neuroscience, International

Hospital Affiliation

Dr. Lee is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Alzheimer's disease
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis

Selected Publications:

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q: Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews. Neuroscience 13 (1): 38-50,2011.

Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121 (2): 726-38,2011.

Liu Elaine Y, Russ Jenny, Wu Kathryn, Neal Donald, Suh Eunran, McNally Anna G, Irwin David J, Van Deerlin Vivianna M, Lee Edward B: C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta neuropathologica 128 (4): 525-41,2014.

Russ Jenny, Liu Elaine Y, Wu Kathryn, Neal Donald, Suh EunRan, Irwin David J, McMillan Corey T, Harms Matthew B, Cairns Nigel J, Wood Elisabeth M, Xie Sharon X, Elman Lauren, McCluskey Leo, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B: Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta neuropathologica 129 (1): 39-52,2015.

McMillan Corey T, Russ Jenny, Wood Elisabeth M, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren, Van Deerlin Vivanna, Lee Edward B: C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology 84 (16): 1622-30,2015.

Academic Contact Info

613A Stellar Chance Laboratories
422 Curie Blvd

Philadelphia, PA 19104
Phone: (215) 898-0908
Patient appointments: 800-789-7366 (PENN)