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Research Interest Summary: The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.
Rubtsova, N.I., Hart, M.C., Arroyo, A.D., Osharovich, S.A., Liebov, B.K., Miller, J., Yuan, M., Cochran, J.M., Chong, S., Yodh, A.G., Busch, T.M., Delikatny, E.J., Anikeeva, N., and Popov, A.V.: NIR fluorescent imaging and photodynamic therapy with a novel theranostic phospholipid probe for triple-negative breast cancer cells Bioconjugate Chemistry 18 (32): 1852-1863,2021.
Bryski, M.G., Frenzel-Sulyok, L.G., Delikatny, E.J., Deshpande, C., Litzky, L.A., and Singhal, S..: Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation PLoS One 16 (6): e0252731,2021.
Azari, F., Kennedy, G., Bernstein, E., Delikatny, E.J., Lee, J., Kucharczuk, J., Low, P.S., and Singhal, S.: Evaluation of OTL38-generated tumor-to-background ratio in intraoperative molecular imaging-guided lung cancer resections Molecular imaging and Biology : 2021.
Teng, C.W., Cho, S.S., Singh, Y., De Ravin, E., Somers, K., Buch, L., Brem, S., Singhal, S., Delikatny, E.J., and Lee, J.: Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery Journal of Neurosurgery 2 : 1-10,2021.
Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK: Evaluation of diagnostic accuracy following the coadministration of Delta-Aminolevulinic Acid and second window indocyanine green in rodent and human glioblastomas Molecular Imaging and Biology : 1266-1279,2020.
Teng, C.W., Amirshaghaghi, A., Cho, S.S., Cai, S.S., De Ravin, E., Singh, Y., Miller, J., Sheikh, S., Delikatny, E.J., Cheng, Z., Busch, T.M., Dorsey, J.F., Singhal, S., Tsourkas, A., and Lee, J.: Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. Journal of Neurooncology 149 (2): 243-254,2020.
Alejandro D Arroyo, Andrea E Guzmán, Alexander V Kachur, Sarah J Saylor, Anatoliy V Popov, E James Delikatny: Development of fluorinated naphthofluoresceins for Cerenkov imaging Journal of Fluorine Chemistry 225 : 27-34,2019.
Alejandro D. Arroyo, Andrea E. Guzmán, Alexander V. Kachur, Sarah J.Saylor, Anatoliy V.Popov, E. James Delikatny: Development of fluorinated naphthofluoresceins for Cerenkov imaging Journal of Fluorine Chemistry 225 : 27-34,2019.
Predina JD, Newton AD, Corbett C, Shin M, Sulfyok LF, Okusanya OT, Delikatny EJ, Nie S, Gaughan C, Jarrar D, Pechet T, Kucharczuk JC, and Singhal S: Near-infrared intraoperative imaging for minimally invasive pulmonary metastasectomy for sarcomas.
J Thorac Cardiovasc Surg. 157 (5): 2061-2069,2019.
Chiorazzo MG, Tunset HM, Popov AV, Johansen B, Moestue S, Delikatny EJ.: Detection and Differentiation of Breast Cancer Sub-Types using a cPLA2α Activatable Fluorophore Scientific Reports 16 (9): 6122,2019.
Hospital of the University of Pennsylvania,Department of Radiology,317 Anatomy Chemistry Building3620 Hamilton Walk