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Douglas B. Cines, MD

Douglas B. Cines, MD Physician

Director, Coagulation Laboratory Director, Office of Faculty Development, Pathology and Laboratory Medicine Professor of Pathology and Laboratory Medicine Professor of Medicine

Dr. Cines is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Hematology, 1980
  • Internal Medicine, 1975

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University School of Medicine
Residency: University of North Carolina Hospitals
Fellowship: Hospital of the University of Pennsylvania


American Association for the Advancement of Science, National American Association of Immunologists, National American Federation for Clinical Research, National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National Federation of Clinical Immunology Societies, National Platelet Disorder Support Association, National

Hospital Affiliation

Dr. Cines is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Thormbosis, fibrinolysis, vascular biology, immunohematology

Selected Publications:

Pishko Allyson M, Misgav Mudi, Cuker Adam, Cines Douglas B, George James N, Vesely Sara K, Terrell Deirdra R: Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists. Journal of thrombosis and thrombolysis 46 (1): 24-30,2018.

Dai Jing, Madeeva Daria, Hayes Vincent, Ahn Hyun Sook, Tutwiler Valerie, Arepally Gowthami M, Cines Douglas B, Poncz Mortimer, Rauova Lubica: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood : 2018.

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK. Translational stroke research : 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2 (3): 165-176,2018.

Raouva, L., Arepally, G., Poncz, M. and Cines, D.B: Pathogenesis of heparin-induced thrombocytopenia Autoimmunity Reviews : 2018.

Florova, G., Azghani, A., Karandashova, S., Schaefer, C., Yarovoi S.V., Declerck, P.J., Cines, D.B., Idell, S. and Komissarov, A.A.: Targeting Plasminogen Activator Inhibitor 1 in Tetracycline-Induced Pleural Injury in Rabbits Am J Physiol Lung Cell Molec Physiol 314 (1): L54-L68,2018.

108., Cuker, C., Marturano, J.E., Carinato, M., Lowery, T.J. and Cines, D.B.: T2 magnetic resonance to monitor hemostasis Seminars in Haemostasis and Thrombosis : 2018.

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R.: ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model Blood Advances 1 (18): 1452-65,2017.

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L.: Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT). ISTH. Berlin, Germany : 2017.

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M.: Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia? ISTH. Berlin, Germany : 2017.

View all publications

Academic Contact Info

Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-3966
Patient appointments: 800-789-7366 (PENN)

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