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Douglas B. Cines, MD

Douglas B. Cines, MD Physician

Director, Coagulation Laboratory Director, Office of Faculty Development, Pathology and Laboratory Medicine Professor of Pathology and Laboratory Medicine Professor of Medicine

Dr. Cines is employed by Penn Medicine.

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About Dr. Douglas B. Cines

My areas of clinical expertise include coagulation and immune hematological disorders.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Hematology, 1980
  • Internal Medicine, 1975

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University School of Medicine
Residency: University of North Carolina Hospitals
Fellowship: Hospital of the University of Pennsylvania


Am. Soc. Hematol. Thrombocytopenia, National American Association for the Advancement of Science, National American Association of Immunologists, National American Federation for Clinical Research, National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National American Society of Hematology, National Federation of Clinical Immunology Societies, National Platelet Disorder Support Association, National

Hospital Affiliation

Dr. Cines is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Thormbosis, fibrinolysis, vascular biology, immunohematology

Selected Publications:

McDaniel Jenny K, Abdelgawwad Mohammad S, Hargett Audra, Renfrow Matthew B, Bdeir Khalil, Cao Wenjing, Cines Douglas B, Zheng X Long: Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols. Journal of thrombosis and haemostasis : JTH 17 (4): 596-606,2019.

Cuker Adam, Marturano Joseph E, Carinato Maria E, Lowery Thomas J, Cines Douglas B: T2 Magnetic Resonance to Monitor Hemostasis. Seminars in thrombosis and hemostasis 45 (3): 247-252,2019.

Tutwiler Valerie, Peshkova Alina D, Le Minh Giang, Zaitsev Sergei, Litvinov Rustem I, Cines Douglas B, Weisel John W: Blood clot contraction differentially modulates internal and external fibrinolysis. Journal of thrombosis and haemostasis : JTH 17 (2): 361-370,2019.

Abu-Fanne Rami, Stepanova Victoria, Litvinov Rustem I, Abdeen Suhair, Bdeir Khalil, Higazi Mohamed, Maraga Emad, Nagaswami Chandrasekaran, Mukhitov Alexander R, Weisel John W, Cines Douglas B, Higazi Abd Al-Roof: Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability. Blood 133 (5): 481-493,2019.

Khandelwal Sanjay, Ravi Joann, Rauova Lubica, Johnson Alexandra, Lee Grace M, Gilner Jennifer B, Gunti Sreenivasulu, Notkins Abner L, Kuchibhatla Maragatha, Frank Michael, Poncz Mortimer, Cines Douglas B, Arepally Gowthami M: Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. Blood 132 (23): 2431-2440,2018.

Gollomp Kandace, Kim Minna, Johnston Ian, Hayes Vincent, Welsh John, Arepally Gowthami M, Kahn Mark, Lambert Michele P, Cuker Adam, Cines Douglas B, Rauova Lubica, Kowalska M Anna, Poncz Mortimer: Neutrophil accumulation and NET release contribute to thrombosis in HIT. JCI insight 3 (18): 2018.

Pishko Allyson M, Misgav Mudi, Cuker Adam, Cines Douglas B, George James N, Vesely Sara K, Terrell Deirdra R: Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists. Journal of thrombosis and thrombolysis 46 (1): 24-30,2018.

Dai Jing, Madeeva Daria, Hayes Vincent, Ahn Hyun Sook, Tutwiler Valerie, Arepally Gowthami M, Cines Douglas B, Poncz Mortimer, Rauova Lubica: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood : 2018.

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK. Translational stroke research : 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2 (3): 165-176,2018.

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Academic Contact Info

Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-3966
Patient appointments: 800-789-7366 (PENN)

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