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Donald L. Siegel, MD, PhD

Donald L. Siegel, MD, PhD Physician

Director, Division of Transfusion Medicine and Therapeutic Pathology Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Siegel is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology, 1992

Clinical Expertise:

  • Blood Banking
  • Blood Cancer
  • Bone Marrow Diseases
  • Bone Marrow Transplant
  • Cancer Screening and Diagnostics
  • Hematopoietic Stem Cell Collection
  • Immunohematology
  • Monoclonal Antibodies (mAbs) Therapy
  • Therapeutic Apheresis

Description of Clinical Expertise

transfusion medicine, blood banking, apheresis, hematopoietic stem cell collection/processing, cGMP manufacture of cellular therapies for phase I first-in-human clinical trials

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association of Blood Banks, National American Society for Apheresis, National American Society of Hematology, National Clinical Applications and Standards Committee, American Society for Apheresis, National Executive Committee of the Medical Advisory Board, Penn-Jersey Division of the American Red Cross, Local International Society for Cellular Therapy, International John Morgan Society, Local Medical Advisory Committee, Penn-Jersey Division of the American Red Cross, Local NIH Study Section "Selected Topics in Transfusion Medicine" (ZRG1 VH-E 50R), National NIH, Member, Selected Topics in Transfusion Medicine Study Section, National Scientific Subsection Committee, American Association of Blood Banks, National

Hospital Affiliation

Dr. Siegel is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests

Discovery and characterization of diagnostic and therapeutic monoclonal antibodies

Research Summary

My laboratory studies human immune repertoires in health and disease using phage display technologies for the production of human and non-human monoclonal antibodies relevant to transfusion medicine, benign hematology, infectious diseases, and oncology. Current studies focus on developing targeted drug delivery methods using red cell antibodies coupled to novel anti-thrombotic/anti-inflammatory molecules; cloning monoclonal primate neutralizing Dengue, Ebola, MERS and Zika virus antibodies for human in vivo antibody gene expression therapy; and isolating recombinant human and humanized antibody fragments for the design of T-cell chimeric antigen receptors for cancer therapy.

Selected Publications:

Villa, C.H., Pan, D.C., Johnston, I., Greineder, C.F., Walsh, L., Hood, E., Cines, D.B., Poncz, M., Siegel, D.L., Muzykantov, V.R.: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes Blood Advances 2 : 165-176,2018.

Villa, C.H., Marcos-Contreras, O.A., Greineder, C.F., Hood, E., Shuvaeva, T., Walsh, L., Meyerson, J., Glassman, P., Brenner, J.S., Siegel, D.L., Muzykantov, V.R.: Red blood cell targeting of liposomes provides markedly enhanced circulation Center for Targeted Therapeutics and Translation Nanomedicine Annual Symposium : 2017.

Villa C.H., Cines D.B., Siegel D.L., Muzykantov V.R.: Erythrocytes as carriers for drug delivery in blood transfusion and beyond Transfusion Medicine Reviews 31 : 26-35,2017.

Fraietta J.A., Lacey S.F., Orlando E.J., Pruteanu-Malinici I., Gohil M., Lundh S., Boesteanu A.C., Wang Y., O’Connor R.S., Hwang W.-T., Pequignot E., Ambrose D.E., Zhang C., Wilcox N., Bedoya F., Dorfmeir C., Chen F., Tian L., Parakandi H., Gupta M., Young R.M., Johnson F.B., Kulikovskaya I., Liu L., Xu J., Kassim S.H., Suhoski-Davis M.M., Levine B.L., Frey N.V., Siegel D.L., Huang A.C., Wherry E.J., Bitter H., Brogdon J.L., Porter D.L., June C.H., Melenhorst J.J.: Identification of functional determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia Blood 130 : 3181,2017.

Carnemolla, R., Villa, C.H., Greineder, C.F., Zaitsev, S., Kowalska, A., Atochin, D.N., Cines, D.B., Siegel, D.L., Esmon, C.T. Muzykantov, V.R.: Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury FASEB J 31 : 761-770,2017.

Beigel, J.H., Tebas, P., Elie-Turenne, Marie-Carmelle, et al: Immune plasma for the treatment of severe influenza: an open-label, multicenter, phase 2 randomised study The Lancet Respiratory Medicine 5 : 500-511,2017.

Chen, J., Zheng, Q., Hammers, C.M., Ellebrecht, C., Mukherjee, C., Tang, H-Y., Lin, C., Yuan, H-J., Pan, M., Langenhan, J., Komorowski, L., Siegel, D.L., Payne, A.S., Stanley, J.R.: Proteomic analysis of pemphigus autoantibodies indicates a much larger, more diverse, and dynamic repertoire than determined by B-cell genetics Cell Reports 18 : 237-247,2017.

Ostertag, E.M., Bdeir, K., Kacir, S., Thiboutot, M., Gulendran, G., Yunk, L., Hayes, V.M., Motto, D.G., Poncz, M., Zheng, X.L., Cines, D.B., Siegel, D.L.: ADAMTS13 Autoantibodies Cloned from Patients with Acquired Thrombotic Thrombocytopenic Purpura: 2. Pathogenicity in an animal model Transfusion 56 : 1775-1785,2016.

Zhao A., Tohidkia M.R., Siegel D.L., Coukos G., Omidi Y.: Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy Critical Reviews in Biotechnology 36 : 276-289,2016.

Ostertag, E.M., Kacir, S., Thiboutot, M., Gulendran, G., Zheng, X.L., Cines, D.B., Siegel, D.L.: ADAMTS13 Autoantibodies Cloned from Patients with Acquired Thrombotic Thrombocytopenic Purpura: 1. Structural and functional characterization in vitro Transfusion 56 : 1763-1774,2016.

View all publications

Academic Contact Info

9-112 South Tower, Big 421
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 662-3942
Patient appointments: 800-789-7366 (PENN)

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