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Donald L. Siegel, MD, PhD

Donald L. Siegel, MD, PhD Physician

Director, Division of Transfusion Medicine and Therapeutic Pathology Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Siegel is employed by Penn Medicine.

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About Dr. Donald L. Siegel

My areas of clinical expertise include transfusion medicine, blood banking, apheresis, hematopoietic stem cell collection/processing, and cGMP manufacture of cellular therapies for phase I first-in-human clinical trials.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology, 1992

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association of Blood Banks, National American Society for Apheresis, National American Society of Hematology, National Clinical Applications and Standards Committee, American Society for Apheresis, National Executive Committee of the Medical Advisory Board, Penn-Jersey Division of the American Red Cross, Local International Society for Cellular Therapy, International John Morgan Society, Local Medical Advisory Committee, Penn-Jersey Division of the American Red Cross, Local NIH Study Section "Selected Topics in Transfusion Medicine" (ZRG1 VH-E 50R), National NIH, Member, Selected Topics in Transfusion Medicine Study Section, National Scientific Subsection Committee, American Association of Blood Banks, National

Hospital Affiliation

Dr. Siegel is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests

Discovery and characterization of diagnostic and therapeutic monoclonal antibodies

Research Summary

My laboratory studies human immune repertoires in health and disease using phage display technologies for the production of human and non-human monoclonal antibodies relevant to transfusion medicine, benign hematology, infectious diseases, and oncology. Current studies focus on developing targeted drug delivery methods using red cell antibodies coupled to novel anti-thrombotic/anti-inflammatory molecules; cloning monoclonal primate neutralizing Dengue, Ebola, MERS and Zika virus antibodies for human in vivo antibody gene expression therapy; and isolating recombinant human and humanized antibody fragments for the design of T-cell chimeric antigen receptors for cancer therapy.

Selected Publications:

Tebas, P., Jadlowsky, J., Shaw, P., Lee, G., Ando, D., Kim, S., Naing, S.Y., Lacey, S., Levine, B.L., Siegel, D.L., June, C.H., Riley, J.L.: Delayed Viral rebound during ATI after infusion of CCR5 ZFN-treated CD4 T cells. 2019 Conference on Retroviruses and Opportunistic Infections (CROI) : 2019.

Villa, C.H., Pan, D.C., Johnston, I., Greineder, C.F., Walsh, L., Hood, E., Cines, D.B., Poncz, M., Siegel, D.L., Muzykantov, V.R.: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes Blood Advances 2 : 165-176,2018.

Nobles, C.L., Everett, J.K., Reddy, S., Fraietta, J.A., Porter, D.L., Frey, N.V., Grupp, S.A., Siegel, D.L., Lacey, S.F., June, C.H., Bushman, F.D., Melenhorst, J.J.: Vector integration and efficacy of CD19-directed CAR T cell therapy in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Blood 132 : 4548,2018.

Melenhorst, J.J., Porter, D.L., Tian, L., Lacey, S.F., Nobles, C.L., Fraietta, J.A., Frey, N.V., Kulikovskaya, I., Gupta, M., Young, R.M., Ambrose, D.E., Siegel, D.L., Bushman, F.D., June, C.H. Long-term remission of CLL sustained by pauciclonal anti-CD19 chimeric antigen receptor t (CTL019) cell clones.: Long-term remission of CLL sustained by pauciclonal anti-CD19 chimeric antigen receptor t (CTL019) cell clones Blood 132 : 699,2018.

Hammers, C.M., Yuan, H., Lin, C., Tang, H.Y., Siegel, D.L., Stanley, J.R.: Cloning and analysis of bullous pemphigoid anti-BP180 IgG and IgE autoantibodies indicates predominance of VL1-47 gene usage and direct (from IgM) and indirect (through IgG) class switching to IgE Exp Dermatol 27 : E64-E65,2018.

Dancy, E., Garfall, A.L., Cohen, A.D., Fraietta, J.A., Davis, M., Levine, B.L., Siegel, D.L., Stadtmauer, E.A., Vogl, D.T., Waxman, A., Rapoport, A.P., Milone, M.D., June, C.H., Melenhorst, J.J.: Clinical predictors of T cell fitness for CAR T cell manufacturing and efficacy in multiple myeloma Blood 132 : 1886,2018.

Chong, E.A., Levine, B.L., Grupp, S.A., Davis, M., Siegel, D.L., Maude, S.L., Gladney, W.L., Frey, N.V., Porter, D.L., June, C.H., Schuster, S.J.: CD19-directed CAR T-cell (CTL019) product viability and clinical outcomes in non-Hodgkin lymphomas and B-cell acute lymphoblastic leukemia Blood 132 : 197,2018.

Garfall, A., Stadtmauer, E., Hwang, W.-T., Lacey, S., Melenhorst, J., Krevvata, M., Carroll, M., Matsui, W., Wang, Q., Dhodapkar, M., Dhodapkar, K., Das, R., Vogl, D., Weiss, B., Cohen, A., Mangan, P., Ayers, E., Nunez-Cruz, S., Kulikovskaya, I., Davis, M., Lamontagne, A., Dengel, K., Kerr, N., Young, R., Siegel, D.L., Levine, B., Milone, M.C., Maus, M., June, C.H.: Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma JCI Insight 3 : e120505,2018.

Robust automated cell counter and viability measurement for engineered T cell product release,: Ohayon, Y., Corl, C.M., Leskowitz, R.M., Malykhin, A., Arostegui, S.M., Hennesy, N.A, Ngo, S., Levine, B.L., Siegel, D.L., Fesnak, A., Davis, M.M. Cytotherapy 20 : S69,2018.

Fraietta, J.A., Lacey, S.F., Orlando, E.J., Pruteanu-Malinici, I., Gohil, M., Lundh, S., Boesteanu, A.C., Wang, Y., O'Connor, R.S., Hwang, W.-T., Pequignot, E., Ambrose, D.E., Zhang, C., Wilcox, N., Bedoya, F., Dorfmeir, C., Chen, F., Tian, L., Parakandi, H., Gupta, M., Young, R.M., Johnson, F.B., Kulikovskaya, I., Liu, L., Xu, J., Kassim, S.H., Suhoski-Davis, M.M., Levine, B.L., Frey, N.V., Siegel, D.L., Huang, A.C., Wherry, E.J., Bitter, H., Brogdon, J.L., Porter, D.L., June, C.H., Melenhorst, J.J: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia Nature Medicine 24 : 563-571,2018.

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Academic Contact Info

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Phone: (215) 662-3942
Patient appointments: 800-789-7366 (PENN)

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