Donald L. Siegel, MD, PhD

Bhoj, V.G., Kaminski, M., Zhao, H., Jackson, K., Montgomery, R.A., Ali, N., Mangiola, M., Spitzer, T.R., Safa, K., Pattanayak, V., Taj, R., Joy Chiu, J., Bui, T.-M., Sonnenberg, E.M., Markmann, J.F., Milone, M.C., June, C.H., Siegel, D.L., Fraietta, J.A., Gonzalez, V., Locci, M., Palmer, M., Monos, D., Hwang, W.-T .Sledge, T., Bridges, N.D., Goldstein, J.S., Odim, J., Sweet, S.C., Besharatian, B.D., Hussain, S.M., Brown, N.K., Kamoun, M., Garfall, A.L., Naji, A. Kidney transplant in two highly-sensitized candidates post-CAR T cell therapy , N Engl J Med, in press: 2026

Barber-Rotenberg, J.S., Haas, A.R., Aggarwal, C., O'Hara, M.H., Hexner, E., Pequignot, E., Dowd, E., Ndeupen, S., Thai, E., Chen, F., Oner, B.S., Czuczman, C., Gonzalez, V.E., Fraietta, J.A., Hwang, W.-T., Chew, A., Jadlowsky, J.K., Marshall, A., Shea, K.-M., Jiang, Y., Cosey, A., Ferthio, R., Plesa, G., Siegel, D.L., Young, R.M., Sheppard, N.C., Albelda, S.M., June, C.H., Tanyi, J.L. Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers , Molecular Therapy, in press: 2026

93., Scholler, J., Song, A., Deshmukh, M., Song, D., Gabunia, K., Ji, M., Fan, T.J., June, C.H., Siegel, D.L. Engineering a juxtamembrane-targeting CAR T-cell against mesothelin: A novel binder resilient to shed antigen for enhanced efficacy against ovarian and pancreatic cancer , Frontiers in Immunology, 17:1805950: 2026

Gu, M., Read, K., Bhardwaj, V., Carvalho, E., Nardo, D., Shayne, J., Shukla, D., Liu, W., Siegel, D.L., Sheppard, N., Milone, M., Cohen, A., Garfall, A., Riley, J.L. Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels , Journal of Experimental Medicine, 223 (6): e20252564: 2026

Paruzzo, L. Chong, E.R., Chong, E.A., Zheng, Z., Guruprasad, P., Landsburg, D.J., Nasta, S.D., Stella, F., Ramasubramanian, R., de Souza, V.B., Alkhatib, M.H., Ho, M., Imparato, A., Chen, G.M., Siegel, D.L., Plesa, G., Dai, A., Mackey, S., Das, P., Michener, P., Jadlowsky, J., Bushman, F.D., Patel, V., Carturan, A., Napier, E.B., Gonzalez, V.E., Jarocha, D., Xu, R., Levine, B.L., Porazzi, P., Frey, N., Porter, D.L., Svoboda, J., Fraietta, J.A., June, C.H., Schuster, S.J., Ruella, M. Decade-long persistence of CD19 CAR T-cells in B-cell lymphomas , Nature Medicine, in press: 2026

Noll, J.H., Dersh, D., Li, J.Y., Hemani, H., Lavorando, M., Bartoszek, R., Amses, K., Jain, A., Minehart, J., Ho, M., Ramirez-Fernandez, A., Paruzzo, L., Shestov, M., Camerini, E., Peters, Huang, X., Loren, A., Woyach, J., Goronzy, J., Kater, A.P., Ruella, M., Byrd, J., Powell, D., Gill S., Porter, D., Schuster, S., Bushman, F.D., Siegel, D.L., Levine, B.L., June, C.H., Frey, N., Cohen, A., Garfall, A., Long, M., Maus, M., Weng, N.-P., Diorio, C., Fraietta, J.A. T-cell immunosenescence limits CD19 CAR T-cell function in chronic lymphocytic leukemia , Blood, in press: 2026

Chen, G.M., Gering, D., Satulovsky, J., Datta, S., Lai, P., Karar, J., Gonzalez, V.E., Alexander, K., Chew, A., Jadlowsky, J.K., Ruella, M., Paruzzo, L., Amses, K.R., Rech, A.J., Stadtmauer, E.A., Frey, N.V., Hexner, E.O., Porter, D.L., Cohen, A.D., Gill, S.I., Garfall, A.L., Schuster, S.J., Mo, K.C., Liang, S.I., Spasic, M., Levine, B.L., Siegel, D.L., Ramírez- Fernández, A., Mackall, C.L., Bushman, F.D., Good, Z., E. John Wherry, E.J., June, C.H., Jain, A., Cabanski, C., Fraietta, J.A. Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-hematologic cancer , Nature Biomedical Engineering: 2026

Ramírez-Fernández, A., Bear, A., Kamali, E., Bartoszek, R., Ho, M., Chen, G., Dersh, D., Cordoba-Espejo, L., Liu, J., Deng, M., Velasco-Sidro, M., Jain, A., Noll, J.H., Hopkins, C., Koucky, O., Minehart, J., Dimitri, A., Williams, E., Lavorando, M., Segura-Tudela, A., Scholler, J., Barber-Rotenberg, J., Jadlowsky, J., Powell, D., Gonzalez, V., Siegel, D.L., Bruce Levine, B., Lotze, M., June, C., Riley, J., Vonderheide, R., Herbst, F., Fraietta, J.A. A modular γδ TCR-T platform combining KRAS pMHC targeting with re-dosable mRNA engager redirection , J. Hematology Oncology, in press: 2026

Jadlowsky, J.K., Hexner, E.O., Marshall, A., Grupp, S.A., Frey, N.V., Riley, J.L., Veloso, E., McConville, H., Rogal, W., Czuczman, C., Hwang, W.-T., Li, Y., Leskowitz, R.M., Farrelly, O., Karar, J., Christensen, S., Barber-Rotenberg, J., Gaymon, A., Aronson, N., Bernstein, W., Melenhorst, J.J., Roche, A.M., Everett, J.K., Zolnoski, S.A., McFarland, A.G., Reddy, S., Petrichenko, A., Cook, E.J., Lee, C., Gonzalez, V.E., Alexander, K., Kulikovskaya, I., Ramírez-Fernández, A., Minehart, J.C., Ruella, M., Gill, S.I., Schuster, S.J., Cohen, A.D., Garfall, A.L., Shah, P.D., Porter, D.L., Maude, S.L., Levine, B.L., Siegel, D.L., Chew, A., McKenna, S., Lledo, L., Davis, M.M, Plesa, G., Herbst, F., Stadtmauer, E.A., Tebas, P., DiNofia, A., Haas, A., Haas, N.B., Myers, R., O’Rourke, D.M., Svoboda, J., Tanyi, J.L., Aplenc, R., Jacobson, J.M., Ko, A.H., Cohen, R.B., June, C.H., Bushman, F.D., Fraietta, J.A. Long-term safety analysis in 783 patients treated with lentiviral or gammaretroviral gene-modified T-cells , Nature Medicine, doi.10.1038/s41591-024-03478-6: 2025

Aznar, M.A., Good, C.R., Barber-Rotenberg, J.S., Agarwal, S., Wilson, W., Watts, A., Zhang, Z., Gonzales, D., Donahue, G., Hwang, W.-T., Rennels, A.K., Rech, A.J., Kuramitsu, S., Glastad, K.M., Alexander, K.A., Plesa, G., Brennan, A., Siegel, D.L., Tanyi, J., Haas, A., Drew Torigian, D., Nadolski, G., Gonzalez, V.E., Hexner, E.O., Fraietta, J.A., Jadlowsky, J.K., Young, R.M., Berger, S.L., June, C.H., O’Hara, M.H. Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer , Cell Reports Medicine, doi/10.1016/j.xcrm.2025.102301: 2025