Donald L. Siegel, MD, PhD

Bhoj, V.G., Kaminski, M., Zhao, H., Jackson, K., Montgomery, R.A., Ali, N., Mangiola, M., Spitzer, T.R., Safa, K., Pattanayak, V., Taj, R., Joy Chiu, J., Bui, T.-M., Sonnenberg, E.M., Markmann, J.F., Milone, M.C., June, C.H., Siegel, D.L., Fraietta, J.A., Gonzalez, V., Locci, M., Palmer, M., Monos, D., Hwang, W.-T .Sledge, T., Bridges, N.D., Goldstein, J.S., Odim, J., Sweet, S.C., Besharatian, B.D., Hussain, S.M., Brown, N.K., Kamoun, M., Garfall, A.L., Naji, A. Kidney transplant in two highly-sensitized candidates post-CAR T cell therapy , N Engl J Med, in press: 2026

Barber-Rotenberg, J.S., Haas, A.R., Aggarwal, C., O'Hara, M.H., Hexner, E., Pequignot, E., Dowd, E., Ndeupen, S., Thai, E., Chen, F., Oner, B.S., Czuczman, C., Gonzalez, V.E., Fraietta, J.A., Hwang, W.-T., Chew, A., Jadlowsky, J.K., Marshall, A., Shea, K.-M., Jiang, Y., Cosey, A., Ferthio, R., Plesa, G., Siegel, D.L., Young, R.M., Sheppard, N.C., Albelda, S.M., June, C.H., Tanyi, J.L. Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers , Molecular Therapy, in press: 2026

Jadlowsky, J.K., Hexner, E.O., Marshall, A., Grupp, S.A., Frey, N.V., Riley, J.L., Veloso, E., McConville, H., Rogal, W., Czuczman, C., Hwang, W.-T., Li, Y., Leskowitz, R.M., Farrelly, O., Karar, J., Christensen, S., Barber-Rotenberg, J., Gaymon, A., Aronson, N., Bernstein, W., Melenhorst, J.J., Roche, A.M., Everett, J.K., Zolnoski, S.A., McFarland, A.G., Reddy, S., Petrichenko, A., Cook, E.J., Lee, C., Gonzalez, V.E., Alexander, K., Kulikovskaya, I., Ramírez-Fernández, A., Minehart, J.C., Ruella, M., Gill, S.I., Schuster, S.J., Cohen, A.D., Garfall, A.L., Shah, P.D., Porter, D.L., Maude, S.L., Levine, B.L., Siegel, D.L., Chew, A., McKenna, S., Lledo, L., Davis, M.M, Plesa, G., Herbst, F., Stadtmauer, E.A., Tebas, P., DiNofia, A., Haas, A., Haas, N.B., Myers, R., O’Rourke, D.M., Svoboda, J., Tanyi, J.L., Aplenc, R., Jacobson, J.M., Ko, A.H., Cohen, R.B., June, C.H., Bushman, F.D., Fraietta, J.A. Long-term safety analysis in 783 patients treated with lentiviral or gammaretroviral gene-modified T-cells , Nature Medicine, doi.10.1038/s41591-024-03478-6: 2025

Bloch, E.M., Triulzi, D., Sachais, B.S., Hod, E.A., Cushing, M., Jacobs, J.W., Tobian, A.A.R., Shan, H., Leonard N. Chen, L.N., McGonigle, A.M., Tormey, C.A., Szczepiorkowski, Z.M., Siegel, D.L. The incompatible match for transfusion medicine fellowships , Transfusion, 65: 2025,246-248

Chen, G.M., Gering, D., Satulovsky, J., Datta, S., Lai, P., Karar, J., Gonzalez, V.E., Alexander, K., Chew, A., Jadlowsky, J.K., Ruella, M., Paruzzo, L., Amses, K.R., Rech, A.J., Stadtmauer, E.A., Frey, N.V., Hexner, E.O., Porter, D.L., Cohen, A.D., Gill, S.I., Garfall, A.L., Schuster, S.J., Mo, K.C., Liang, S.I., Spasic, M., Levine, B.L., Siegel, D.L., Ramírez- Fernández, A., Mackall, C.L., Bushman, F.D., Good, Z., E. John Wherry, E.J., June, C.H., Jain, A., Cabanski, C., Fraietta, J.A. Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-hematologic cancer , Nature Biomedical Engineering, in press: 2025

Svoboda, J., Landsburg, D.J., Gerson, J., Nasta, S.D., Barta, S.K., Chong, E.A., Cook, M., Frey, N.V., Shea, J., Cervini, A., Marshall, A., Four, M., Davis, M.M., Jadlowski, J.K., Chew, A., Pequignot, E., Gonzalez, V., Noll, J.H., Paruzzo, L., Rojas-Levine, J., Plesa, G., Schollar, J., Siegel, D.L., Levine, B., Porter, D.L., Ghassemi, S., Ruella, M., Rech, A., Leskowitz, R.M., Fraietta, J.A., Hwang, W.-T., Hexner, E., Schuster, S.J., June, C.H. Enhanced CAR T-cell therapy for lymphoma after previous failure , New England J Med, 392: 2025,1824-1835

Bagley, S.J., Desai, A.S., Fraietta, J.A., Silverbush, D., Chafamo, D., Freeburg, N.F., Gopikrishna, G.K., Rech, A.J., Nabavizadeh, A., Bagley, L.J., Park, J., Jarocha, D., Martins, R., Sarmiento, N., Maloney, E., Lledo, L., Stein, C., Marshall, A., Leskowitz, R.M., Jadlowsky, J.K., Mackey, S., Christensen, S., Oner, B.S., Plesa, G., Brennan, A., Gonzalez, V. Chen, F., Barrett, D., Colbourn, R., Nasrallah, M.P., Mourelatos, Z., Hwang, W.-T., Alanio, C., Siegel, D.L., June, C.H., Hexner, E.O., Binder, Z.A., O'Rourke, D.M. Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial , Nature Medicine, doi/10.1038/s41591-025-03745-0: 2025

Ramirez-Fernández, A., Dimitri, A., Chen, F., Bartoszek, R., Chen, G., Córdoba-Espejo, L., Zhou, Y., Tang, Y.H., Lin, C.-T., Acosta, R., Scholler, J., Ghilardi, G., Porazzi, P., Pellicer, M., Profitós-Pelejà, N., Barta, S., Chew, A., Jadlowsky, J., Vanessa Gonzalez, V., Siegel, D.L., Levine, B., Roué, G., Ruella, M., Lotze, M., June, C.H., Riley, J., Fraietta, J. CCR5-targeted allogeneic gamma-delta CD19 CAR T cells for HIV-associated B cell malignancy immunotherapy , Nature Biomedical Engineering: 2025

Myers, R.M., DiNofia, A.M., Li, Y., Diorio, C., Liu, H., Wertheim, G., Fraietta, J.A., Gonzalez, V., Plesa, G., Siegel, D.L., Iannone, E., Shinehouse, L., Brogdon, J.L., Taylor, C., Jadlowsky, J.K., Hexner, E.O., Engels, B., Baniewicz, D., Callahan, C., Ruella, M., Aplenc, R., Leahy, A.B., McClory, S.E., Rheingold, S.R., Wray, L., June, C.H., Maude, S.L., Frey, N.V., Grupp, S.A. CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy , J Immunoherapy Cancer, doi:10.1136/jitc-2025-011549: 2025

Aznar, M.A., Good, C.R., Barber-Rotenberg, J.S., Agarwal, S., Wilson, W., Watts, A., Zhang, Z., Gonzales, D., Donahue, G., Hwang, W.-T., Rennels, A.K., Rech, A.J., Kuramitsu, S., Glastad, K.M., Alexander, K.A., Plesa, G., Brennan, A., Siegel, D.L., Tanyi, J., Haas, A., Drew Torigian, D., Nadolski, G., Gonzalez, V.E., Hexner, E.O., Fraietta, J.A., Jadlowsky, J.K., Young, R.M., Berger, S.L., June, C.H., O’Hara, M.H. Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer , Cell Reports Medicine, doi/10.1016/j.xcrm.2025.102301: 2025