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Donald M. O'Rourke, MD

Donald M. O'Rourke, MD Physician

Director, Human Brain Tumor Tissue Bank John Templeton, Jr., M.D. Associate Professor in Neurosurgery

Dr. O'Rourke is employed by Penn Medicine.

About Dr. Donald M. O'Rourke

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia magazine's Top Docs issue from 2005 to 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Acoustic Neuroma (Vestibular Schwannoma)
  • Arnold-Chiari Malformation
  • Astrocytoma
  • Brain Cancer
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Cancer Surgery
  • Cervical Degenerative Disc Disease
  • Cervical Myelopathy
  • Cervical Spine Surgery
  • Gamma Knife
  • Glioma
  • Meningioma
  • Metastatic Cancer
  • Radiosurgery
  • Skull Base Cancer
  • Spinal Cord Cancer
  • Spinal Degenerative Disease
  • Spinal Stenosis
  • Spinal Tumor
  • Spine Disorders
  • Spine Microsurgery
  • Spondylosis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurological Surgery, National American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons (AANS), National California Institute for Regenerative Medicine (CIRM), National College of Physicians of Philadelphia, Local Congress of Neurological Surgeons, National National Institutes of Health, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Society for Neuro-Oncology, National Society for Neuroscience, National

Hospital Affiliation

Dr. O'Rourke is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Selected Publications:

Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, Desai AS: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma. J Neurooncol : 2018.

Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma Nature Communications 9 (1): 2018.

Yin Y, Boesteanu, AC, Binder, ZA, Xu C, Reid RA, Rodriguez J L, Cook DR; Thokala, R, Blouch, K McGettigan-Croce B, Zhang L, Konradt Christoph, Cogdill, AP, Panjwani, MK; Jiang S, Migliorini, D, Dahmane N, Posey Jr, AD; June CH, Mason NJ, Lin, Z, Johnson, LA, O’Rourke, DM: Checkpoint blockade reverses anergy in IL13Rα2 humanized scFv based CAR T cells to treat murine and canine gliomas. Molecular Therapy-Oncolytics : 2018.

Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson C, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Orellana L, Scott AM, Davatzikos C, Furnari FB, O'Rourke DM.: Epidermal Growth Factor Receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development. Cancer Cell 34 (1): 163-177.e7,2018.

Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA.: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI J Magn Reson Imaging : 2018.

Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics offering prognostic value beyond IDH1 Sci Reports 8 (1): 5087,2018.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol : 2018.

Wang Q, He Z, Huang M, Liu Y, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2a Nature Communications 9 (1): 559,2018.

Morris J, NA YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J.: Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing. Cell Reports 21 (10): 2706-2713,2017.

Roccograndi L, Binder ZA, Zhang L, Aceta N, Zhang Z, Bentores-Alj M, Nakano, I, Dahmane N, O’Rourke DM.: Shp2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol 135 (3): 487-496,2017.

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Patient appointments: 800-789-7366 (PENN)

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