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Donald M. O'Rourke, MD

Donald M. O'Rourke, MD Physician

Director, Human Brain Tumor Tissue Bank John Templeton, Jr., M.D. Professor in Neurosurgery

Dr. O'Rourke is employed by Penn Medicine.

About Dr. Donald M. O'Rourke

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia magazine's Top Docs issue from 2005 to 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Abnormal Vertebrae
  • Absent Vertebrae
  • Accessory Nerve Injury
  • Acoustic Neurofibromatosis
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Acoustic Neuroma Removal
  • Acromegaly
  • Anaplastic Astrocytoma
  • Anaplastic Ependymoma
  • Anaplastic Mixed Glioma
  • Anaplastic Oligoastrocytoma
  • Aneurysms
  • Ankylosing Spondylitis
  • Anterior Temporal Lobectomy
  • Anterior Vertebral Body Tethering
  • Aqueductal Stenosis
  • Arachnoid Cyst
  • Arnold Chiari Malformation
  • Arterial Malformation of the Brain
  • Arteriovenous Malformations (AVM)
  • Artificial Disc Replacement Surgery in the Cervical Spine
  • Artificial Disc Replacement Surgery in the Lumbar Spine
  • Astrocytic Cancer
  • Astrocytoma Tumors
  • Auditory Brainstem Implant
  • AVM Embolization
  • Awake Craniotomy
  • Back Injuries
  • Back Surgery
  • Benign Neoplasm of Brain
  • Berry Aneurysm
  • Biological Enhancement of Spinal Fusion
  • Biopsy of the Brain
  • Biopsy of the Skull
  • Bone Cyst
  • Bone Growth Stimulator
  • Bone Tumors
  • Brachial Nerve Tumors
  • Brachial Plexus Injury
  • Brain Cancer Genomics
  • Brain Laceration
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumor Bleeding
  • Brain Tumors
  • Broken Coccyx
  • Bulging Disc
  • Burr Hole
  • Carotid Stenosis
  • Cauda Equina Syndrome
  • Cavernous Hemangioma
  • Cavernous Sinus Thrombosis
  • Central Nervous System Tumors
  • Central Venous Stenosis
  • Cerebellar Tumor
  • Cerebral Aneurysm
  • Cerebral Angiogram
  • Cerebral Angiogram with Aneurysm Embolization
  • Cerebral Angiogram with Coiling
  • Cerebral Angiogram with Stenting
  • Cerebral Artery Bypass Surgery
  • Cerebral Cyst
  • Cerebral Decompression
  • Cerebral Edema
  • Cerebral Hernia
  • Cerebral Revascularization
  • Cerebrospinal Fluid (CSF) Leak
  • Cerebrovascular Accident
  • Cerebrovascular Bypass Surgery
  • Cervical Arthritis
  • Cervical Bone Spur
  • Cervical Compression Fracture
  • Cervical Decompression
  • Cervical Deformity
  • Cervical Disc Degeneration
  • Cervical Disc Disease
  • Cervical Disc Displacement
  • Cervical Disc Herniation
  • Cervical Laminoplasty
  • Cervical Laminotomy
  • Cervical Radiculopathy
  • Cervical Revision Surgery
  • Cervical Spinal Fracture
  • Cervical Spinal Fusion Surgery
  • Cervical Spinal Stenosis
  • Cervical Spine Surgery
  • Cervical Steroid Injection
  • Chiari Decompression
  • Cholesteatoma
  • Chordoma
  • Choroid Plexus Tumor
  • Cingulotomy
  • Clipping of Brain Aneurysm
  • Clivus Chondroma
  • CNS Lymphoma
  • Coccyx Injury
  • Colloid Cyst
  • Common Carotid Artery Embolization
  • Complex Spinal Deformities
  • Complex Spinal Surgery
  • Compression Fractures
  • Congenital Malformation of the Spine
  • Congenital Scoliosis
  • Cordotomy
  • Corpus Callosotomy Surgery
  • Cortical Mapping
  • Cranial Nerve Disorders
  • Cranial Nerve Injuries
  • Cranial Nerve Palsy
  • Cranial Nerve Repair
  • Cranial Puncture
  • Craniectomy
  • Craniocele
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • CSF Shunt Removal
  • Decompression Laminectomy
  • Decompression Median Nerve At Elbow
  • Deep Brain Stimulation
  • Deep Brain Stimulation for Dystonia
  • Deep Brain Stimulation while Asleep
  • Deep Brain Stimulation while Awake
  • Degenerative Spine Conditions
  • Disc Arthroplasty
  • Disc Replacement
  • Disc Surgery
  • Diskectomy
  • Dorsal Column Stimulator
  • Dural Arteriovenous Fistula
  • Dural Based Tumor
  • Dural Sinus Thrombosis
  • Dystonia
  • EGFR Translocation
  • Electrocorticography
  • Embryonal Cell Tumors of the Brain
  • Embryonal Tumors
  • Encephalocele Repair
  • Endodermal Sinus Tumor
  • Endonasal Transsphenoidal Approach
  • Endoscopic Endonasal Approach
  • Endoscopic Fusion
  • Endoscopic Neurosurgery
  • Endoscopic Third Ventriculostomy
  • Ependymoma
  • Epidural Hematoma
  • Epidural Hemorrhage
  • Epidural Injection
  • Epilepsy
  • Epilepsy Surgery
  • Erdheim-Chester Disease
  • Essential Tremor
  • Evaluation for Epilepsy Surgery
  • Extradural Abscess
  • Extreme Lateral Interbody Fusion
  • Facet Injection
  • Facet Surgery
  • Facial Nerve Schwannoma
  • Facial Pain
  • Facial Spasm
  • Failed Back Surgery Syndrome (FBSS)
  • Fibrillary Astrocytoma
  • Flatback Syndrome Post Harrington Rods
  • Flow Diversion for Cerebral Aneurysms
  • Foot Drag
  • Gamma Knife
  • Gamma Knife Perfexion
  • Ganglioglioneurocytoma
  • Ganglioma
  • Ganglioneuroblastoma
  • Ganglioneurocytoma
  • Germ Cell Tumors
  • Germinoma
  • Glioblastoma
  • Glioma
  • Gliomatosis Cerebri
  • Gliosarcoma
  • Glomus Jugulare Tumor
  • Glossopharyngeal Neuralgia
  • Growing Rods
  • Head and Neck Osteoma
  • Head Reconstruction
  • Hemangioblastoma
  • Hemangiopericytoma
  • Hemispherectomy
  • Herniated Disc
  • Hydrocephalus
  • Hypothalamic Hamartoma
  • Image Guided Biopsy of the Spine
  • Injury of Optic Chiasm
  • Intracranial Abscess
  • Intracranial Arterial Bypass
  • Intracranial Arterial Occlusion
  • Intracranial Hemangioma
  • Intracranial Hemorrhage
  • Intracranial Hypotension
  • Intracranial Mass
  • Intraoperative MRI
  • Intraspinal Abscess
  • Intraventricular Endoscopy
  • Intraventricular Tumor
  • Junctional Kyphosis
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Kyphosis
  • Laminectomy
  • Laminoplasty
  • Lateral Access Spine Surgery
  • Leptomeningeal Carcinomatosis
  • Leptomeningeal Disease
  • Lesion of Median Nerve
  • Lesion of Popliteal Nerve
  • Lesion of Posterior Tibial Nerve
  • Lesion of Sciatic Nerve
  • Lesionectomies
  • Lesionectomy
  • Lhermitte-Duclos Disease
  • Lipomyelomeningocele
  • Lobectomy of Brain
  • Low Back Surgery
  • Lower Back Injuries
  • Lower Back Pain
  • Lumbar Drain
  • Lumbar Scoliosis
  • Lumbar Spinal Fracture
  • Lumbar Spinal Fusion
  • Lumbar Spinal Injury
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumbar Stress Fracture
  • Lumboperitoneal Shunt Placement
  • Lumbosacral Plexus Lesion
  • Lumbosacral Radiculopathy
  • Malignant Neoplasm of the Brain Stem
  • Malignant Neoplasm of the Cerebellum
  • Malignant Neoplasm of the Frontal Lobe
  • Malunion Fracture of the Spine
  • Medulloblastoma
  • Medulloepithelioma
  • Meningioma
  • Meningocele
  • Metastatic Brain Cancer
  • Microdiscectomy
  • Microneurosurgery
  • Microsurgery
  • Microvascular Decompression
  • Microvascular Surgery
  • Minimally Invasive Partial Lumbar Discectomy
  • Minimally Invasive Spinal Fusion
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Moyamoya
  • Myelopathy
  • Myelopathy Surgery
  • Myxopapillary Ependymoma
  • Neck Masses and Lumps
  • Neck Tumors
  • Needle Biopsy of Brain
  • Needle Biopsy of Cerebral Meninges
  • Neoplasm of Brain Stem
  • Nerve Sheath Tumor
  • Neuroblastoma
  • Neurocutaneous Disorders
  • Neuroectodermal Tumor
  • Neuroendocrine Tumors
  • Neuroendoscopy
  • Neurofibromatosis
  • Neurofibromatosis Type 1 (NF1)
  • Neurofibromatosis Type 2
  • Neurofibrosarcoma
  • Neurogenic Claudication
  • Neurointerventional Biplane Angiography System
  • Neuromuscular Scoliosis
  • Neuronal Glial Tumors
  • Nonruptured Cerebral Aneurysm
  • Normal Pressure Hydrocephalus
  • Occipito-Cervical Fusion
  • Olfactory Neuroblastoma
  • Oligoastrocytoma
  • Oligodendroglioma
  • Open Biopsy of the Brain
  • Optic Nerve Decompression
  • Optic Nerve Glioma
  • Optic Nerve Sheath Meningioma
  • Optic Nerve Surgery
  • Orbital Nerve Decompression
  • Orbital Tumors
  • Osteoarthritis of the Spine
  • Paraganglioma
  • Parkinson's Disease
  • Parkinson's Surgery
  • Percutaneous Trigeminal Rhizotomy
  • Peripheral Nerve Disorders
  • Peripheral Nerve Surgery
  • Peripheral Nerve Tumors
  • Peripheral Schwannoma
  • Periventricular Lesion
  • Periventricular Mass
  • Personal History of Malignant Neoplasm of Brain
  • Petrous Apex Tumor
  • Pilocytic Astrocytoma
  • Pineal Gland Parenchymal Tumor
  • Pineal Tumor
  • Pineoblastoma
  • Pituitary Adenoma
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Cervical Laminectomy and Fusion
  • Posterior Lumbar Laminectomy
  • Post-Laminectomy Kyphosis
  • Post-Laminectomy Syndrome
  • Primary Brain Tumor
  • Prolactinoma
  • Radiculopathy
  • Rathke's Cleft Cysts
  • Repair of Brain
  • Resection of Cerebral Arteriovenous Malformation
  • Retinoblastoma
  • Revision of Spinal Surgery
  • Rhizotomy
  • Robotic Spine Surgery
  • Ruptured Brain Aneurysm
  • Ruptured Intervertebral Disc
  • Sacral Nerve Stimulation
  • Sacroiliac Joint Block
  • Sacroiliac Joint Fusion
  • Sacroiliac Joint Surgery
  • Scheuermann Disease
  • Scheuermann's Kyphosis
  • Schwannomatosis
  • Sciatica
  • Scoliosis Surgery
  • Selective Dorsal Rhizotomy
  • Sinonasal Undifferentiated Carcinoma
  • Skull Base Approach
  • Skull Base Tumors
  • Skull Fracture
  • Spina Bifida
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Stimulator
  • Spinal Cord Surgery
  • Spinal Cord Tumors
  • Spinal Cyst Removal
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Embolization
  • Spinal Fracture
  • Spinal Fusion
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Reconstruction
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tethering for Scoliosis
  • Spinal Tumor
  • Spine Decompression
  • Spine Deformity
  • Spine Deformity Correction Surgery
  • Spine Injuries
  • Spine Stapling
  • Spondylectomy
  • Spondyloarthropathy
  • Spondylolisthesis
  • Spondylosis
  • Spondylosis Surgery
  • Spondylosis With Myelopathy
  • Spondylosyndesis
  • Spongioblastoma
  • Standard Transsphenoidal Approach
  • Stereotactic Brain Biopsy
  • Stereotactic EEG
  • Stereotactic Radiosurgery
  • Stereotactic Radiotherapy
  • Subarachnoid Hemorrhage
  • Subcaudate Tractotomy
  • Subdural Hematoma
  • Subdural Hemorrhage
  • Subependymal Giant Cell Astrocytoma
  • Subpial Transection
  • Superior Canal Dehiscence
  • Surgery for Sciatica
  • Surgery for Spasticity
  • Surgical Treatment of Myelopathy
  • Sympathectomy
  • Syringobulbia
  • Syringomyelia
  • Tarlov Cysts
  • Temporal Tumor
  • Tethered Spinal Cord
  • Thoracic Disc Herniation
  • Thoracic Laminectomy
  • Thoracic Spinal Fracture
  • Thoracic Spinal Fusion
  • Thoracic Spinal Injury
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Topectomy
  • Transnasal Repair CSF Leak
  • Transpetrosal Approaches
  • Trigeminal Nerve Disorders
  • Ulnar Nerve Decompression
  • Ulnar Nerve Surgery
  • Vagal Nerve Stimulator
  • Vagal Stimulation
  • Vascular Brain Tumors
  • Vascular Malformations of the Brain
  • Vascular Malformations of the Spine
  • Vein of Galen Malformation
  • Venous Malformation Brain
  • Ventricular Shunt
  • Ventriculo Peritoneal Shunt
  • Ventriculocisternostomy
  • Ventriculostomy
  • Vertebrae Surgery
  • Vertebral Epiphysitis
  • Vertebral Fracture
  • Vertebral Stapling
  • Visualase MRI-Guided Laser Ablation
  • X-Stop Surgery
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurological Surgery, National American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons (AANS), National California Institute for Regenerative Medicine (CIRM), National College of Physicians of Philadelphia, Local Congress of Neurological Surgeons, National Empirica Rx, International Isoma Therapeutics, National National Institutes of Health, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Society for Neuro-Oncology, National Society for Neuroscience, National

Hospital Affiliation

Dr. O'Rourke is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Selected Publications:

S Mohan, S Wang, G Coban, F Kural, S Chawla, D O’Rourke, H Poptani: Detection of Occult Neoplastic Infiltration in the Corpus Callosum and Prediction of Overall Survival in Patients with Glioblastoma using Diffusion Tensor Imaging European Journal of Radiology : 2019 .

Hoffman DI, Abdullah KG, McCoskey M, Binder ZA, O'Rourke DM, Desai AS, Nasrallah MP, Bigdeli A, Morrissette JJD, Brem S, Bagley SJ: Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma. J Neurooncol : 2019.

Wen PY, Reardon DA, Armstrong TS, Phuphanich S, Aiken RD, Landolfi JC, Curry WT, Zhu JJ, Glantz M, Peereboom DM, Markert J, LaRocca R, O'Rourke DM, Fink K, Kim L, Gruber M, Lesser GJ, Pan E, Kesari S, Muzikansky A, Pinilla C, Santos RG, Yu JS: A Randomized Double-Blind Placebo-Controlled Phase 2 Trial Of Dendritic Cell Vaccine ICT-107 In Newly Diagnosed Patients With Glioblastoma. Clin Cancer Res : pii: clincanres.0261.2019,2019.

Nabavizadeh SA, Akbari H, Ware JB, Nasrallah M, Guiry S, Bagley SJ, Desai A, Levy S, Sarchiapone W, Prior T, Detre J, Wolf RL, O'Rourke DM, Brem S, Davatzikos C: Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma. Sci Reports 9 (1): 8747,2019.

Nasrallah MP, Binder ZA, Oldridge DA, Zhao J, Lieberman DB, Roth JJ, Watt CD, Sukhadia S, Klinman E, Daber RD, Desai A, Brem S, *Morrissette JJD, *O'Rourke DM: Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma. Academic Pathology 6 : 2374289519848353,2019.

Viaene AN, Zhang B, Martinez-Lage M, Xiang C, Tosi U, Thawani JP, Gungor B, Zhu Y, Roccograndi L, Zhang L, Bailey RL, Storm PB, O'Rourke DM, Resnick AC, Grady MS, Dahmane N: Transcriptome signatures associated with meningioma progression. Acta Neuropathol Commun 7 (1): 67,2019.

Ahmed FI, Abdullah KG, Durgin J, Salinas RD, O'Rourke DM, Brem S: Evaluating the Association Between the Extent of Resection and Survival in Gliosarcoma. Cureus 11 (4): e4374,2019.

Caplan IF, Sullivan PZ, Kung D, O'Rourke DM, Choudhri O, Glauser G, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population. World Neurosurg. 19 : pii: S1878-8750(19)30849-6,2019.

Liu T, Xu H, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y.: Circulating Glioma Cells Exhibit Stem Cell-like Properties. Clin Cancer Res 78 (23): 6632-6642,2018.

Verma G, Chawla S, Mohan S, Wang S, Nasrallah M, Sheriff S, Desai A, Brem S, O'Rourke DM, Wolf RL, Maudsley AA, Poptani H.: Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma. NMR Biomed : 2018.

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Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Patient appointments: 800-789-7366 (PENN)

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