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Donald M. O'Rourke, MD Surgeon

Director, Human Brain Tumor Tissue Bank
Associate Professor of Neurosurgery

Dr. O'Rourke is a Penn Medicine employed physician.

About Dr. Donald M. O'Rourke

Recognized annually in Philadelphia Magazine's Top Docs issue from 2005 through 2016

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Acoustic Neuromas
  • Arnold-Chiari Malformation
  • Astrocytoma
  • Brain Cancer
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Cancer – Neuro Oncology
  • Cancer Surgery
  • Cervical Degenerative Disc Disease
  • Cervical Myelopathy
  • Cervical Spine Surgery
  • Gamma Knife®
  • Glioma
  • Lumbar Degenerative Disease
  • Meningioma
  • Metastatic Cancer
  • Radiosurgery
  • Skull Base Cancer
  • Spinal Cord Cancer
  • Spinal Stenosis
  • Spinal Tumor
  • Spine Disorders
  • Spine Microsurgery
  • Spondylosis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Neurological Surgery, National American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons Research Foundation, National American Association of Neurological Surgeons, National Congress of Neurological Surgeons, National Department of Veterans Affairs, Merit Review Program, Department of Medical Research, National Fellow, College of Physicians of Philadelphia, Local National Institutes of Health, Cancer Diagnostics and Treatments SBIR/STTR Panel, National Pediatric Brain Tumor Consortium, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Section on Tumors, American Association of Neurological Surgeons and Congress of Neurological Surgeons, National Society for Neuro-Oncology, National Society for Neuroscience, National The Wellcome Trust, United Kingdom, Scientific Review Committee, International

Hospital Affiliation

Dr. O'Rourke is a Penn Medicine employed physician.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Huang Menggui, Liu Tianrun, Ma Peihong, Mitteer R Alan, Zhang Zhenting, Kim Hyun Jun, Yeo Eujin, Zhang Duo, Cai Peiqiang, Li Chunsheng, Zhang Lin, Zhao Botao, Roccograndi Laura, O'Rourke Donald M, Dahmane Nadia, Gong Yanqing, Koumenis Constantinos, Fan Yi: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of clinical investigation : 2016.

Akbari Hamed, Macyszyn Luke, Da Xiao, Bilello Michel, Wolf Ronald L, Martinez-Lage Maria, Biros George, Alonso-Basanta Michelle, O'Rourke Donald M, Davatzikos Christos: Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery 78 (4): 572-80,2016.

Macyszyn Luke, Akbari Hamed, Pisapia Jared M, Da Xiao, Attiah Mark, Pigrish Vadim, Bi Yingtao, Pal Sharmistha, Davuluri Ramana V, Roccograndi Laura, Dahmane Nadia, Martinez-Lage Maria, Biros George, Wolf Ronald L, Bilello Michel, O'Rourke Donald M, Davatzikos Christos: Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro-oncology 18 (3): 417-25,2016.

Coban G, Mohan S, Kural F, Wang S, O'Rourke D M, Poptani H: Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas. AJNR. American journal of neuroradiology 36 (7): 1247-52,2015.

Walsh Alice M, Kapoor Gurpreet S, Buonato Janine M, Mathew Lijoy K, Bi Yingtao, Davuluri Ramana V, Martinez-Lage Maria, Simon M Celeste, O'Rourke Donald M, Lazzara Matthew J: Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Molecular cancer research : MCR 13 (8): 1227-37,2015.

Jabehdar Maralani Pejman, Melhem Elias R, Wang Sumei, Herskovits Edward H, Voluck Matthew R, Kim Sang Joon, Learned Kim O, O'Rourke Donald M, Mohan Suyash: Association of dynamic susceptibility contrast enhanced MR Perfusion parameters with prognosis in elderly patients with glioblastomas. European radiology 25 (9): 2738-44,2015.

Chowdhury Imran H, Ojerholm Eric, McMillan Matthew T, Miller Denise, Kolker James D, Kurtz Goldie, Dorsey Jay F, Nagda Suneel N, Geiger Geoffrey A, Brem Steven, O'Rourke Donald M, Zager Eric L, Gangadhar Tara, Schuchter Lynn, Lee John Y K, Alonso-Basanta Michelle: Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases. Radiation oncology (London, England) 10 : 248,2015.

Abdullah Kalil G, Ramayya Ashwin, Thawani Jayesh P, Macyszyn Lukasz, Martinez-Lage Maria, O'Rourke Donald M, Brem Steven: Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PloS one 10 (5): e0127202,2015.

Vogel Jennifer, Ojerholm Eric, Hollander Andrew, Briola Cynthia, Mooij Rob, Bieda Michael, Kolker James, Nagda Suneel, Geiger Geoffrey, Dorsey Jay, Lustig Robert, O'Rourke Donald M, Brem Steven, Lee John, Alonso-Basanta Michelle: Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases. Radiation oncology (London, England) 10 : 221,2015.

Ojerholm Eric, Lee John Y K, Thawani Jayesh P, Miller Denise, O'Rourke Donald M, Dorsey Jay F, Geiger Geoffrey A, Nagda Suneel, Kolker James D, Lustig Robert A, Alonso-Basanta Michelle: Stereotactic radiosurgery to the resection bed for intracranial metastases and risk of leptomeningeal carcinomatosis. Journal of neurosurgery 121 Suppl : 75-83,2014.

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Fax: (215) 349-5534
Patient appointments: 800-789-PENN (7366)

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