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Donald M. O'Rourke, MD

Donald M. O'Rourke, MD Physician

Director, Human Brain Tumor Tissue Bank John Templeton, Jr., M.D. Professor in Neurosurgery

Dr. O'Rourke is employed by Penn Medicine.

About Dr. Donald M. O'Rourke

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia magazine's Top Docs issue from 2005 to 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Abnormal Vertebrae
  • Absent Vertebrae
  • Acoustic Neuroma (Vestibular Schwannoma)
  • Aneurysms
  • Ankylosing Spondylitis
  • Anterior Vertebral Body Tethering
  • Arteriovenous Malformations (AVM)
  • Artificial Disc Replacement Surgery in the Cervical Spine
  • Artificial Disc Replacement Surgery in the Lumbar Spine
  • Auditory Brainstem Implant
  • Back Injuries
  • Back Surgery
  • Biological Enhancement of Spinal Fusion
  • Bone Cyst
  • Bone Growth Stimulator
  • Bone Tumors
  • Brachial Plexus Injury
  • Brain Metastasis
  • Brain Surgery
  • Brain Tumors
  • Broken Coccyx
  • Bulging Disc
  • Cauda Equina Syndrome
  • Cerebrospinal Fluid (CSF) Leak
  • Cervical Arthritis
  • Cervical Bone Spur
  • Cervical Compression Fracture
  • Cervical Decompression
  • Cervical Deformity
  • Cervical Disc Degeneration
  • Cervical Disc Disease
  • Cervical Disc Displacement
  • Cervical Disc Herniation
  • Cervical Laminoplasty
  • Cervical Laminotomy
  • Cervical Radiculopathy
  • Cervical Revision Surgery
  • Cervical Spinal Fracture
  • Cervical Spinal Fusion Surgery
  • Cervical Spinal Stenosis
  • Cervical Spine Surgery
  • Cervical Steroid Injection
  • Cholesteatoma
  • Chordoma
  • Coccyx Injury
  • Complex Spinal Deformities
  • Complex Spinal Surgery
  • Compression Fractures
  • Congenital Malformation of the Spine
  • Congenital Scoliosis
  • Cordotomy
  • Corpus Callosotomy Surgery
  • Craniocervical Junction Surgery
  • Craniopharyngioma
  • Craniotomy
  • Decompression Laminectomy
  • Decompression Median Nerve At Elbow
  • Deep Brain Stimulation
  • Degenerative Spine Conditions
  • Disc Arthroplasty
  • Disc Replacement
  • Disc Surgery
  • Diskectomy
  • Dorsal Column Stimulator
  • Dystonia
  • Endoscopic Fusion
  • Epidural Injection
  • Epilepsy
  • Epilepsy Surgery
  • Essential Tremor
  • Extreme Lateral Interbody Fusion
  • Facet Injection
  • Facet Surgery
  • Failed Back Surgery Syndrome (FBSS)
  • Flatback Syndrome Post Harrington Rods
  • Foot Drag
  • Gamma Knife
  • Germ Cell Tumors
  • Glioblastoma
  • Growing Rods
  • Head and Neck Osteoma
  • Herniated Disc
  • Intraspinal Abscess
  • Junctional Kyphosis
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Kyphosis
  • Laminectomy
  • Laminoplasty
  • Lateral Access Spine Surgery
  • Lesion of Popliteal Nerve
  • Lesion of Posterior Tibial Nerve
  • Lesion of Sciatic Nerve
  • Low Back Surgery
  • Lower Back Injuries
  • Lower Back Pain
  • Lumbar Scoliosis
  • Lumbar Spinal Fracture
  • Lumbar Spinal Fusion
  • Lumbar Spinal Injury
  • Lumbar Spinal Mass
  • Lumbar Spinal Stenosis
  • Lumbar Spinal Tumor
  • Lumbar Stress Fracture
  • Lumbosacral Plexus Lesion
  • Lumbosacral Radiculopathy
  • Microdiscectomy
  • Microsurgery
  • Microvascular Decompression
  • Minimally Invasive Partial Lumbar Discectomy
  • Minimally Invasive Spinal Fusion
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Myelopathy
  • Myelopathy Surgery
  • Neck Masses and Lumps
  • Neck Tumors
  • Neurocutaneous Disorders
  • Neuroendocrine Tumors
  • Neurofibromatosis Type 1 (NF1)
  • Neurogenic Claudication
  • Neuromuscular Scoliosis
  • Occipito-Cervical Fusion
  • Orbital Tumors
  • Osteoarthritis of the Spine
  • Parkinson's Disease
  • Peripheral Nerve Disorders
  • Peripheral Nerve Tumors
  • Pituitary Surgery
  • Pituitary Tumors
  • Posterior Cervical Laminectomy and Fusion
  • Posterior Lumbar Laminectomy
  • Post-Laminectomy Kyphosis
  • Post-Laminectomy Syndrome
  • Prolactinoma
  • Radiculopathy
  • Revision of Spinal Surgery
  • Rhizotomy
  • Robotic Spine Surgery
  • Ruptured Intervertebral Disc
  • Sacral Nerve Stimulation
  • Sacroiliac Joint Block
  • Sacroiliac Joint Fusion
  • Sacroiliac Joint Surgery
  • Scheuermann Disease
  • Scheuermann's Kyphosis
  • Sciatica
  • Scoliosis Surgery
  • Selective Dorsal Rhizotomy
  • Skull Base Tumors
  • Spina Bifida
  • Spinal Abscess
  • Spinal Abscess Surgery
  • Spinal Cord Cancer
  • Spinal Cord Compression
  • Spinal Cord Disorder
  • Spinal Cord Stimulator
  • Spinal Cord Surgery
  • Spinal Cyst Removal
  • Spinal Deformity
  • Spinal Dural Graft
  • Spinal Fracture
  • Spinal Fusion
  • Spinal Mass
  • Spinal Meningioma
  • Spinal Microsurgery
  • Spinal Reconstruction
  • Spinal Schwannoma
  • Spinal Stenosis
  • Spinal Tethering for Scoliosis
  • Spinal Tumor
  • Spine Decompression
  • Spine Deformity
  • Spine Deformity Correction Surgery
  • Spine Injuries
  • Spine Stapling
  • Spondylectomy
  • Spondyloarthropathy
  • Spondylolisthesis
  • Spondylosis
  • Spondylosis Surgery
  • Spondylosis With Myelopathy
  • Spondylosyndesis
  • Stereotactic Radiosurgery
  • Surgery for Sciatica
  • Surgical Treatment of Myelopathy
  • Tarlov Cysts
  • Tethered Spinal Cord
  • Thoracic Disc Herniation
  • Thoracic Laminectomy
  • Thoracic Spinal Fracture
  • Thoracic Spinal Fusion
  • Thoracic Spinal Injury
  • Thoracic Spinal Mass
  • Thoracic Spinal Stenosis
  • Thoracic Spinal Tumor
  • Trigeminal Nerve Disorders
  • Ulnar Nerve Decompression
  • Ulnar Nerve Surgery
  • Vascular Malformations of the Spine
  • Vertebrae Surgery
  • Vertebral Epiphysitis
  • Vertebral Fracture
  • Vertebral Stapling
  • Visualase MRI-Guided Laser Ablation
  • X-Stop Surgery
View More

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurological Surgery, National American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons (AANS), National California Institute for Regenerative Medicine (CIRM), National College of Physicians of Philadelphia, Local Congress of Neurological Surgeons, National Empirica Rx, International Isoma Therapeutics, National National Institutes of Health, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Society for Neuro-Oncology, National Society for Neuroscience, National

Hospital Affiliation

Dr. O'Rourke is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Selected Publications:

S Mohan, S Wang, G Coban, F Kural, S Chawla, D O’Rourke, H Poptani: Detection of Occult Neoplastic Infiltration in the Corpus Callosum and Prediction of Overall Survival in Patients with Glioblastoma using Diffusion Tensor Imaging European Journal of Radiology : 2019 .

Wen PY, Reardon DA, Armstrong TS, Phuphanich S, Aiken RD, Landolfi JC, Curry WT, Zhu JJ, Glantz M, Peereboom DM, Markert J, LaRocca R, O'Rourke DM, Fink K, Kim L, Gruber M, Lesser GJ, Pan E, Kesari S, Muzikansky A, Pinilla C, Santos RG, Yu JS: A Randomized Double-Blind Placebo-Controlled Phase 2 Trial Of Dendritic Cell Vaccine ICT-107 In Newly Diagnosed Patients With Glioblastoma. Clin Cancer Res : pii: clincanres.0261.2019,2019.

Nabavizadeh SA, Akbari H, Ware JB, Nasrallah M, Guiry S, Bagley SJ, Desai A, Levy S, Sarchiapone W, Prior T, Detre J, Wolf RL, O'Rourke DM, Brem S, Davatzikos C: Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma. Sci Reports 9 (1): 8747,2019.

Nasrallah MP, Binder ZA, Oldridge DA, Zhao J, Lieberman DB, Roth JJ, Watt CD, Sukhadia S, Klinman E, Daber RD, Desai A, Brem S, *Morrissette JJD, *O'Rourke DM: Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma. Academic Pathology 6 : 2374289519848353,2019.

Viaene AN, Zhang B, Martinez-Lage M, Xiang C, Tosi U, Thawani JP, Gungor B, Zhu Y, Roccograndi L, Zhang L, Bailey RL, Storm PB, O'Rourke DM, Resnick AC, Grady MS, Dahmane N: Transcriptome signatures associated with meningioma progression. Acta Neuropathol Commun 7 (1): 67,2019.

Ahmed FI, Abdullah KG, Durgin J, Salinas RD, O'Rourke DM, Brem S: Evaluating the Association Between the Extent of Resection and Survival in Gliosarcoma. Cureus 11 (4): e4374,2019.

Caplan IF, Sullivan PZ, Kung D, O'Rourke DM, Choudhri O, Glauser G, Osiemo B, Goodrich S, McClintock SD, Malhotra NR: The LACE+ index as a predictor of 30-day readmission in a brain tumor population. World Neurosurg. 19 : pii: S1878-8750(19)30849-6,2019.

Liu T, Xu H, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y.: Circulating Glioma Cells Exhibit Stem Cell-like Properties. Clin Cancer Res 78 (23): 6632-6642,2018.

Verma G, Chawla S, Mohan S, Wang S, Nasrallah M, Sheriff S, Desai A, Brem S, O'Rourke DM, Wolf RL, Maudsley AA, Poptani H.: Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma. NMR Biomed : 2018.

Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP.: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. J Neurooncol : 2018.

View all publications

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Patient appointments: 800-789-7366 (PENN)

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