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Donald M. O'Rourke, MD

Donald M. O'Rourke, MD Surgeon

Director, Human Brain Tumor Tissue Bank John Templeton, Jr., M.D. Associate Professor in Neurosurgery

Dr. O'Rourke is employed by Penn Medicine.

About Dr. Donald M. O'Rourke

Recognized annually in Philadelphia magazine's Top Docs issue from 2005 through 2017

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties

Specialty:

  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1998

Clinical Expertise:

  • Acoustic Neuromas
  • Arnold-Chiari Malformation
  • Astrocytoma
  • Brain Cancer
  • Brain Cancer Gene Therapy
  • Brain Metastasis
  • Brain Tumors
  • Cancer Surgery
  • Cervical Degenerative Disc Disease
  • Cervical Myelopathy
  • Cervical Spine Surgery
  • Gamma Knife
  • Glioma
  • Meningioma
  • Metastatic Cancer
  • Radiosurgery
  • Skull Base Cancer
  • Spinal Cord Cancer
  • Spinal Degenerative Disease
  • Spinal Stenosis
  • Spinal Tumor
  • Spine Disorders
  • Spine Microsurgery
  • Spondylosis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurological Surgery, National American Association for Cancer Research, National American Association for the Advancement of Science, National American Association of Neurological Surgeons Research Foundation, National American Association of Neurological Surgeons, National College of Physicians of Philadelphia, Local Congress of Neurological Surgeons, National Department of Veterans Affairs, Merit Review Program, Department of Medical Research, National National Institutes of Health, Cancer Diagnostics and Treatments SBIR/STTR Panel, National Pediatric Brain Tumor Consortium, National Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Section on Tumors, American Association of Neurological Surgeons and Congress of Neurological Surgeons, National Society for Neuro-Oncology, National Society for Neuroscience, National The Wellcome Trust, United Kingdom, Scientific Review Committee, International

Hospital Affiliation

Dr. O'Rourke is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Selected Publications:

Weller M, Butowski N, Tran DD, Recht L, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust S, Iwamoto F, Drappatz J, O’Rourke DM, et al.: Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): results of a randomized, double-blind, international phase 3 trial. Lancet Oncol. : 2017.

Roccograndi L, Binder ZA, Zhang L, Aceta N, Zhang Z, Bentores-Alj M, Nakano, I, Dahmane N, O’Rourke DM.: Shp2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol : 2017.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma Science Translational Medicine 9 (399): 2017.

Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C.: In vivo detection of EGFRvIII in glioblastoma via perfusion magnetic resonance imaging signature consistent with deep peritumoral infiltration: the φ index. Clin Cancer Res. : 2017.

Bloch O, Lim M, Sughrue ME, Komotar RJ, Abrahams JM, O’Rourke DM, D’Ambrosio A, Bruce JN, Parsa AT.: Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L-1 Expression on Response to Therapy. Clin Cancer Res. : 2017.

Spaethling JM, Na Y-J, Lee J, Ulyanova AV, Baltuch GH, Bell TJ, Brem S, Chen HI, Dueck H, Fisher SA, Garcia MP, Khaladkar M, Kung DK, Lucas TH, O’Rourke DM, Stefanik D, Wang J, Wolf JA, Bartfai T, Grady MS, Sul J-Y, Kim J, Eberwine JH.: Primary cell culture of live neurosurgically resected aged adult human brajn cells and single cell transcriptomics. Cell Reports 18 (3): 791-803,2017.

Sahin N, Mohan S, Maralani PJ, Duddukuri S, O'Rourke DM, Melhem ER, Wolf RL.: Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI. AJR Am J Roentgenol. 207 (6): 1263-1270,2016.

Huang Menggui, Liu Tianrun, Ma Peihong, Mitteer R Alan, Zhang Zhenting, Kim Hyun Jun, Yeo Eujin, Zhang Duo, Cai Peiqiang, Li Chunsheng, Zhang Lin, Zhao Botao, Roccograndi Laura, O'Rourke Donald M, Dahmane Nadia, Gong Yanqing, Koumenis Constantinos, Fan Yi: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of Clinical Investigation 126 (5): 1804-14,2016.

Akbari Hamed, Macyszyn Luke, Da Xiao, Bilello Michel, Wolf Ronald L, Martinez-Lage Maria, Biros George, Alonso-Basanta Michelle, OʼRourke Donald M, Davatzikos Christos: Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery 78 (4): 572-80,2016.

Macyszyn Luke, Akbari Hamed, Pisapia Jared M, Da Xiao, Attiah Mark, Pigrish Vadim, Bi Yingtao, Pal Sharmistha, Davuluri Ramana V, Roccograndi Laura, Dahmane Nadia, Martinez-Lage Maria, Biros George, Wolf Ronald L, Bilello Michel, O'Rourke Donald M, Davatzikos Christos: Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro-oncology 18 (3): 417-25,2016.

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-3490
Patient appointments: 800-789-7366 (PENN)

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