Selected Publications:
Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, Desai AS: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma. J Neurooncol : 2018.
Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma Nature Communications 9 (1): 2018.
Yin Y, Boesteanu, AC, Binder, ZA, Xu C, Reid RA, Rodriguez J L, Cook DR; Thokala, R, Blouch, K McGettigan-Croce B, Zhang L, Konradt Christoph, Cogdill, AP, Panjwani, MK; Jiang S, Migliorini, D, Dahmane N, Posey Jr, AD; June CH, Mason NJ, Lin, Z, Johnson, LA, O’Rourke, DM: Checkpoint blockade reverses anergy in IL13Rα2 humanized scFv based CAR T cells to treat murine and canine gliomas.
Molecular Therapy-Oncolytics : 2018.
Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson C, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Orellana L, Scott AM, Davatzikos C, Furnari FB, O'Rourke DM.: Epidermal Growth Factor Receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development. Cancer Cell 34 (1): 163-177.e7,2018.
Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA.: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI J Magn Reson Imaging : 2018.
Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics offering prognostic value beyond IDH1 Sci Reports 8 (1): 5087,2018.
Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol : 2018.
Wang Q, He Z, Huang M, Liu Y, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2a Nature Communications 9 (1): 559,2018.
Morris J, NA YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J.: Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing. Cell Reports 21 (10): 2706-2713,2017.
Roccograndi L, Binder ZA, Zhang L, Aceta N, Zhang Z, Bentores-Alj M, Nakano, I, Dahmane N, O’Rourke DM.: Shp2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol 135 (3): 487-496,2017.