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Devraj Basu, MD, PhD, FACS

Devraj Basu, MD, PhD, FACS Physician

Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania

Dr. Basu is employed by Penn Medicine.

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About Dr. Devraj Basu

As part of a multidisciplinary team, I am dedicated to optimizing survival for patients with aggressive head and neck cancer cases while managing readily curable ones with the goal of minimizing negative effects of treatment. I have over a decade of experience in managing the most complex head and neck cancer cases as an oncologic and reconstructive surgeon. My NIH-funded research enterprise brings a cutting edge molecular perspective to surgical cancer care while optimizing use of resected tumors to advance the science of cancer therapy. I use open, endoscopic, robotic, and laser procedures to treat both benign and malignant disorders of the mouth, throat, larynx, nose, sinuses, salivary glands, parapharyngeal space, and skin. I am also highly experienced in surgical management of thyroid and parathyroid diseases.

Clinical Specialties

Clinical Expertise:

  • Acinic Cell Cancer
  • Adenocarcinoma of the Head and Neck
  • Adenoid Cystic Carcinoma
  • Adenoidectomy
  • Airway Disorders
  • Alaryngeal Communication
  • All Cancer Types
  • Allergic Fungal Sinusitis
  • Anaplastic Cancer of Thyroid
  • Angiosarcoma
  • Arytenoid Dislocation
  • Atypical Lipomatous Tumor
  • Atypical Melanocytic Neoplasm
  • Balloon Sinuplasty
  • Basal Cell Carcinoma
  • Basalosquamous Cell Carcinoma
  • Base of Skull Surgery
  • Base of Skull Tumors
  • Basosquamous Carcinoma
  • Biological Targeted Therapy
  • Branchial Cleft Cyst
  • Broken Nose (Nose Fracture)
  • Brow Lift
  • Buccal Space Mass
  • Calvarial Reconstruction
  • Cancer Genomics
  • Cancer of the Hard/Soft Palate
  • Cancer of the Nasal Cavity
  • Cancer of the Parotid
  • Cancer of the Supraglottis
  • Cancer of the Vocal Cords
  • Cancer Surgery
  • Carcinoma of Unknown Primary
  • Carcinosarcoma
  • Central Compartment Neck Dissection
  • Cerebrospinal Fluid (CSF) Leak
  • Cerebrospinal Fluid Leak from Nose
  • Cervical Lymphadenopathy
  • Cheek Bone Fractures
  • Cheek Problems
  • Chemoradiation
  • Chondrosarcoma
  • Chronic Rhinosinusitis
  • Chronic Sinus Infection
  • Chronic Tonsillitis
  • Clinical Trials
  • Clonic Hemifacial Spasm
  • Coblation for Tonsillectomy
  • Combined Modality Therapy
  • Craniopharyngioma
  • Cricopharyngeal Achalasia
  • Cricopharyngeal Constricture
  • Cross Face Nerve Graft
  • CSF Leak Repair
  • Cyst of Sinuses
  • Da Vinci Head & Neck Surgery
  • Dacryocystorhinostomy
  • Dedifferentiated Liposarcoma
  • Deviated Septum
  • Difficulty Swallowing (Dysphagia)
  • Digastric Muscle Transfer
  • Distortion of the Face
  • Dysphonia
  • Ear and Temporal Bone Cancer
  • Ear and Temporal Bone Tumors
  • Ear Cancer
  • Ear Mass
  • Ear Melanoma
  • Ear, Nose and Throat Surgery
  • Eccrine Carcinoma
  • Encephalocele Repair
  • Endocrine Surgery
  • Endoscopic Sinus Surgery
  • Esophageal Cancer
  • Esophageal Dilation
  • Esophageal Lesion
  • Ethmoidectomy
  • Eye Socket Fractures
  • Eye Socket Reconstruction
  • Face Cancer
  • Face Infection
  • Face Swelling
  • Facial Abscess
  • Facial Asymmetry Surgery
  • Facial Cyst
  • Facial Deformities
  • Facial Fracture
  • Facial Laceration
  • Facial Lesion
  • Facial Nerve Disorders
  • Facial Nerve Graft
  • Facial Nerve Injury
  • Facial Nerve Palsy
  • Facial Nerve Schwannoma
  • Facial Paralysis Reconstruction
  • Facial Paresis
  • Facial Reanimation Surgery
  • Facial Reconstruction
  • Facial Rehabilitation
  • Facial Trauma
  • Facial Tumor
  • Facial Tumors
  • Fat Grafting
  • Fibrosarcoma
  • Fibrosarcoma of the Head & Neck
  • Fine Needle Aspiration
  • Fissured Tongue
  • Flaps Surgery
  • Follicular Cancer of Thyroid
  • forehead lift
  • Forehead Nodule
  • Foreign Body in Throat
  • Free Flap Neck
  • Free Tissue Transfer Flap
  • Frenectomy
  • Frontal Sinusotomy
  • Frontalis Muscle Transfer
  • Glomus Tumor
  • Glossodynia
  • Glottic Cancer
  • Glottic Stenosis
  • Goiter
  • Gold Eyelid Weight
  • Granular Cell Tumor
  • Growth On Neck
  • Hairy Tongue
  • Head Abscess
  • Head and Neck Cancer
  • Head and Neck Cancer Genomics
  • Head and Neck Melanoma
  • Head and Neck Sarcoma
  • Head and Neck Tumor
  • Head and Neck Tumor Reconstruction
  • Head Cyst
  • Head Lump
  • Head Mass
  • History of Pituitary Mass
  • Hoarseness
  • Human Papilloma Virus
  • Hurthle Cell Cancer
  • Hypercalcemia
  • Hyperparathyroidism
  • Hypoglossal Nerve Disease
  • Hypoglossal Nerve Injury
  • Hypoglossal Nerve Transfers
  • Hypopharyngeal Cancer
  • Injection Medialization Laryngoplasty
  • In-Office Vocal Cord Injection
  • Interposition Nerve Grafts
  • Inverted Papilloma
  • Jaw Bone Graft
  • Jaw Cancer
  • Jaw Deformities
  • Jaw Disorders
  • Jaw Fracture
  • Jaw Injuries
  • Jaw Lesion
  • Jaw Reconstruction
  • Jaw Surgery
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Laryngeal Cancer
  • Laryngeal Dysphagia
  • Laryngeal Dysplasia
  • Laryngeal Dystonia
  • Laryngeal Edema
  • Laryngeal Lesion
  • Laryngeal Leukoplakia
  • Laryngeal Papillomatosis
  • Laryngeal Polyps
  • Laryngeal Stenosis
  • Laryngectomy
  • Laryngitis
  • Laryngocele
  • Laryngomalacia
  • Laryngoscopy
  • Laryngotracheoplasty
  • Laser-Assisted Uvulopalatoplasty
  • Lefort Fracture
  • Leiomyosarcoma
  • Lip Asymmetry
  • Lip Droop
  • Lip Mass
  • Lip Surgery
  • Lipoma
  • Liposarcoma
  • Local Muscle Transfers
  • Lump in Throat
  • Lymph Node Dissection
  • Malignant Fibrous Histiocytoma
  • Malignant Neoplasm of Lip
  • Malignant Neoplasm of Soft Tissue
  • Malignant Primitive Neuroectodermal Tumor (PNET)
  • Mandibular Reconstruction
  • Mandibular Resection Prosthesis
  • Mandibulectomy
  • Masseter-to-Facial Nerve Transfer
  • Maxillary Reconstruction
  • Maxillectomy
  • Maxillofacial Pathology
  • Maxillofacial Trauma
  • Medullary Cancer of Thyroid
  • Melanoma of the Lip
  • Melanoma on Face
  • Melanoma Surgery
  • Meningocele
  • Merkel Cell Carcinoma
  • Metastatic Squamous Neck Cancer with Occult Primary
  • Metastatic Thyroid Cancer
  • Microlaryngeal Laser Surgery
  • Microsurgery
  • Microvascular Flap Reconstruction
  • Microvascular Surgery
  • Minimally Invasive Lymph Node Dissection
  • Minimally Invasive Parathyroid Surgery
  • Minimally Invasive Video-Assisted Thyroidectomy
  • Mouth Abscess
  • Mouth Bleeding
  • Mouth Cancer (Oral Cancer)
  • Mouth Cyst
  • Mouth Infections
  • Mucosal Melanoma
  • Multiple Endocrine Neoplasia
  • Multiple Endocrine Neoplasia Type 1
  • Multiple Endocrine Neoplasia Type 2
  • Multiple Endocrine Neoplasia Type 2A
  • Multiple Endocrine Neoplasia Type 2B
  • Nasal Cancer
  • Nasal Cavity and Paranasal Sinus Cancer
  • Nasal Crusting
  • Nasal Endoscopy
  • Nasal Obstruction
  • Nasal Polyps
  • Nasal Surgery
  • Nasal Trauma
  • Nasopharyngeal Cancer
  • Nasoseptal Reconstruction
  • Neck Abscess
  • Neck Biopsy
  • Neck Cancer
  • Neck Cyst
  • Neck Lymph Nodes
  • Neck Mass Excision
  • Neck Masses and Lumps
  • Neck Plastic Surgery
  • Neck Reconstruction
  • Neuroectodermal Tumor
  • Neurofibrosarcoma
  • Neurologic Disorders of the Larynx
  • Nodular Goiter
  • Novottf Therapy
  • Occipital Mass
  • Odynophagia
  • Oncologic Reconstruction
  • Oncoplastic Surgery
  • Oral Complications of Cancer
  • Oral Inflammation
  • Oral Lesions
  • Oral Pain
  • Oral Pathology
  • Oral Tumor
  • Orofacial Pain
  • Oropharyngeal Cancer
  • Oropharyngeal Disorders
  • Osteoma
  • Osteonecrosis of the Jaw
  • Otalgia
  • Palate Surgery
  • Papillary Cancer of Thyroid
  • Paraganglioma
  • Paranasal Surgery
  • Parapharyngeal Abscess
  • Parapharyngeal Mass
  • Parathyroid Adenoma
  • Parathyroid Cancer
  • Parathyroid Disease
  • Parathyroid Hyperplasia
  • Parathyroid Mass
  • Parathyroidectomy
  • Parotidectomy
  • Peritonsillar Abscess
  • Peroral Endoscopic Myotomy
  • Personalized Cancer Therapy
  • Pharyngeal Flap Surgery
  • Pharyngeal Mass
  • Pituitary Cancer
  • Pleomorphic Sarcoma
  • Polyp of Cheek
  • Preauricular Fistula
  • Precancerous Vocal Cord Dysplasia
  • Primary Hyperparathyroidism
  • Radiation Toxicity
  • Radical Neck Dissection
  • Radioactive Iodine (Radioiodine) Therapy
  • Reconstruction of Nose
  • Reconstruction Orbit
  • Reconstructive Microsurgery
  • Reconstructive Plastic Surgery
  • Rectus Flap Reconstruction
  • Recurrent Thyroid Cancer
  • Reinke's Edema
  • Reirradiation for Recurrent Head and Neck Cancers
  • Remove Sinus Packing
  • Retropharyngeal Abscess
  • Rhabdomyosarcoma
  • Robotic Oral Surgery
  • Salivary Duct
  • Salivary Gland Cancer
  • Salivary Gland Disorders
  • Salivary Gland Swelling
  • Salivary Gland Transfer
  • Sarcoma
  • Scalp Laceration
  • Scalp Reconstruction
  • Scar on Neck
  • Scar Revision
  • Scratchy Voice
  • Sebaceous Carcinoma
  • Sebaceous Gland Tumor
  • Secondary Hyperparathyroidism
  • Sentinel Lymph Node Biopsy
  • Septal Perforation
  • Septoplasty
  • Septum Problem
  • Sialadenitis
  • Sialendoscopy
  • Sialolithiasis
  • Sinonasal Carcinoma
  • Sinonasal Mucocele
  • Sinonasal Papilloma
  • Sinus and Nasal Mucoceles
  • Sinus Cancer
  • Sinus Disorders
  • Sinus Fracture
  • Sinus Infections (Sinusitis)
  • Sinus Mass
  • Sinus Polyp
  • Sinus Surgery
  • Skin Cancer
  • Skin Cancer Reconstructive Surgery
  • Skin Cancer Surgery
  • Skin Grafts
  • Soft Tissue Sarcoma
  • Soft Tissue Sarcoma Radical Tumor Resection
  • Solitary Fibrous Tumor
  • Sore Throat
  • Sphenoidectomy
  • Sphenoidotomy
  • Spindle Cell Sarcoma
  • Spots on Mouth
  • Squamous Cell Carcinoma of the Ear
  • Squamous Cell Carcinoma of the Esophagus
  • Squamous Cell Carcinoma of the Head and Neck
  • Squamous Cell Carcinoma of the Jaw
  • Squamous Cell Carcinoma of the Nose
  • Squamous Cell Carcinoma of the Skin
  • Squamous Cell Carcinoma of the Skin of Lip
  • Squamous Cell Carcinoma of the Temporal Bone
  • Squamous Cell Carcinoma of the Throat
  • Squamous Cell Carcinoma of the Tongue
  • Squamous Cell Carcinoma of the Tonsils
  • Stomatitis
  • Stridor
  • Stylohyoid Syndrome
  • Styloidectomy
  • Subglottic Stenosis
  • Submandibular Gland Excision
  • Submandibular Nodule
  • Submandibular Swelling
  • Submucosal Tumors
  • Suppurative Tonsillitis
  • Swallowing Disorders
  • Swollen Lymph Nodes
  • Swollen Parotid
  • Swollen Throat
  • Synovial Sarcoma
  • Temporal Bone Cancer
  • Temporalis Muscle Transfers
  • Temporomandibular Joint Replacement
  • Temporomandibular Joint Surgery
  • Throat Abscess
  • Throat Cancer
  • Throat Disorders
  • Throat Drainage
  • Throat Mass
  • Thyroglossal Duct Disorders
  • Thyroid Cancer
  • Thyroid Cancer Genomics
  • Thyroid Nodule Biopsy
  • Thyroid Nodules
  • Thyroidectomy
  • Tongue Cancer
  • Tongue Clip
  • Tongue Cyst
  • Tongue Mass
  • Tongue Numbness
  • Tongue Pain
  • Tongue Plaque
  • Tongue Sores
  • Tongue Swelling
  • Tonsil Cancer
  • Tonsil Removal Surgery (Tonsillectomy)
  • Tonsillar Abscess
  • Tonsillar Hypertrophy
  • Tonsillitis (Tonsil Inflammation)
  • Toxic Nodular Goiter
  • Toxic Thyroid Nodule
  • Tracheal Cancer
  • Tracheal Dilatation
  • Tracheal Mass
  • Tracheal Reconstruction
  • Tracheal Stent
  • Tracheal Stomal Stenosis
  • Tracheocutaneous Fistula
  • Tracheostomy Management
  • Transnasal Esophagoscopy
  • Transnasal Repair CSF Leak
  • Transoral Laser Microsurgery
  • TransOral Robotic Surgery (TORS)
  • Transoral Thyroidectomy
  • Tumor of Nose
  • Turbinate Surgery
  • Uprastomal and Tracheal Granulomas
  • Uvulitis
  • Uvuloplasty
  • Vascular Resection and Reconstruction
  • Vermilionectomy
  • Vocal Cord Abnormalities
  • Vocal Cord Dysfunction
  • Vocal Cord Issues
  • Vocal Cord Lesion
  • Vocal Cord Paralysis
  • Vocal Cord Strain
  • Vocal Cord Surgery
  • Vocal Tremor
  • Voice Disorders
  • Voice Prosthesis
  • Well Differentiated Liposarcoma
  • Zenker's Diverticulum
  • Zenker's Diverticulum Surgery
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Washington University
Residency: Barnes-Jewish Hospital - Washington University, St. Louis


American Association for the Advancement of Cancer Research, National American College of Surgeons, National American Head and Neck Society, National American Society of Clinical Oncology, National California Tobacco-Related Disease Research Program, National The Triological Society, National

Hospital Affiliation

Dr. Basu is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

As a surgeon-scientist, my overall goal is to improve our ability cure the most aggressive head and neck cancers while also abating treatment toxicity for ones readily curable by existing therapies. My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. In the process, we have developed the ability to analyze heterogeneity and phenotypic plasticity within cancer cell lines, patient-derived xenografts, and primary human cancer samples based on molecular and functional criteria. My group seeks precise molecular definition of the epigenetic plasticity that promotes homeostasis of tumor cells that retain malignant potential in the face of standard therapy. Our studies integrate known drug resistance mechanisms into a conceptual framework where oncogenic signal dependence is regulated by flux between distinct cell states. Our work demonstrates that activation of oncogenic signaling pathways is remarkably heterogeneous and plastic within any single tumor. As a result, rapid compensation to targeting these pathways occurs not only at the level of signaling networks in individual cells but also through dynamics among diverse cell states cooperatively sustaining cancer progression. We are presently exploiting such intra-tumor diversity as a basis to improve the marginal efficacy of current targeted agents in head and neck cancer therapy with new drug combinations.

Selected Publications:

Harmeyer KM, Facompre ND, Herlyn M, Basu D: JARID1 Histone Demethylases: Emerging Targets in Cancer Trends Cancer 3 (10): 713-725,2017.

Facompre ND, Harmeyer KH, Basu D: Regulation of oncogenic PI3-kinase signaling by JARID1B Oncotarget 8 (5): 7218-7219,2017.

Facompre ND, Harmeyer KM, Sole X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ramaswamy S, Basu D: JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers Cancer Res 76 (18): 5538-49,2016.

Facompre ND, Harmeyer KM, Sahu V, Gimotty PA, Rustgi AK, Nakagawa H, Basu D: Targeting JARID1B's Demethylase Activity Blocks a Subset of Its Functions in Oral Cancer Oncotarget 9 (10): 8985-8998,2017.

Facompre ND, Sahu V, Montone KT, Harmeyer KM, Nakagawa H, Rustgi AD, Weinstein GS, Gimotty PA, Basu D: Barriers to Generating PDX Models of HPV-Related Head and Neck Cancer Laryngoscope 127 (12): 2777-2783,2017.

Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, Long A, Sahu V, Darling D, Que J, Yang Y, Katz J, Wileyto E, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto A, Diehl JA, Bass A, Wong K, Rustgi A, Nakagawa H: Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma Nature Communications 8 (1): 1758,2017.

Basu D, Bewley AF, Sperry SM, Montone KT, Gimotty PA, Rasanen K, Facompre ND, Weinstein GS, Nakagawa H, Diehl JA, Rustgi AK, Herlyn M: EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas Mol Cancer Ther 12 (10): 2176-86,2013.

Facompre N, Nakagawa H, Herlyn M, Basu D: Stem-like cells and therapy resistance in squamous cell carcinomas Adv Pharmacol 65 : 235-65,2012.

Basu D, Montone KT, Wang LP, Gimotty PA, Hammond R, Diehl JA, Rustgi AK, Lee JT, Rasanen K, Weinstein GS, Herlyn M: Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas Cell Cycle 10 (12): 2008-16,2011.

Basu D, Ngyen TK, Montone KT, Zhang BS, Wang L, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M: Evidence for mesenchymal-like subpopulations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity Oncogene 29 (29): 4170-82,2010.

Academic Contact Info


Perelman Center for Advanced Medicine
South Pavilion, 3rd Floor
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3534
Patient appointments: 800-789-7366 (PENN)