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David B. Roth, MD, PhD

David B. Roth, MD, PhD Physician

Chair, Department of Pathology and Laboratory Medicine Director, Penn Center for Precision Medicine Simon Flexner Professor of Pathology and Laboratory Medicine

Dr. Roth is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic Pathology, 1992

Practice Locations and Appointments

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Medical School: Baylor College of Medicine
Residency: National Cancer Institute


Alpha Omega Alpha Medical Honor Society, National Alpha Omega Alpha Medical Honor Society, National American Association for the Advancement of Sciences, National American Association of Immunologists, National American Association of University Pathologists (The Pluto Society), National American Board of Pathology, Diplomate, National American Society for Microbiology, National Association of Pathology Chairs, International Association of Pathology Chairs, National Boston Children's Hospital Scientific Advisory Board, Local College of American Pathologists, National NIH Allergy and Immunology Study Section, Ad Hoc Member, National Northeast Association of Pathology Chairs, National Pathology Society of Philadelphia, Local Pennsylvania Association of Pathologists, Local Society of '67 (Association of Pathology Chairs), National The Harvey Society, National The New York Academy of Sciences, Local

Hospital Affiliation

Dr. Roth is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Luskin MR, Carroll M, Lieberman D, Morrissette JJD, Zhao J, Crisalli L, Roth DB, Luger SM, Porter DL, Reshef D: Clinical utility of next-generation sequencing for oncogenic mutations in patients with acute myeloid leukemia undergoing allogenic stem cell transplantation Biology of Blood and Marrow Transplantation 22 : 1961-67,2016.

Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing PLoS One 11 (4): e0152851,2016.

Roth D: Young but Powerful: Penn Medicine’s Center for Personalized Diagnostics is on a mission to improve patient care using the power of genomics The Pathologist (0316): 402,2016.

Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Nat Commun 7 (10529): 2016.

Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C: Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience Cancer Cytopathol : 2015.

Martina Mijušković, Yi-Fan Chou Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth: Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus Cell Reports 12 : 1842-1852,2015.

Corrigan-Curay Jacqueline, O'Reilly Marina, Kohn Donald B, Cannon Paula M, Bao Gang, Bushman Frederic D, Carroll Dana, Cathomen Toni, Joung J Keith, Roth David, Sadelain Michel, Scharenberg Andrew M, von Kalle Christof, Zhang Feng, Jambou Robert, Rosenthal Eugene, Hassani Morad, Singh Aparna, Porteus Matthew H: Genome Editing Technologies: Defining a Path to Clinic. Molecular therapy: the journal of the American Society of Gene Therapy 23 (5): 796-806,2015.

Wilson Melissa A, Morrissette Jennifer J D, McGettigan Suzanne, Roth David, Elder David, Schuchter Lynn M, Daber Robert D: What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer genetics : 2014.

Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ' Nucleic Acids Research 42 (10): 6352-64,2014.

Academic Contact Info

6.036 Gates Building
3400 Spruce Street

Philadelphia, PA 19104-4283
Phone: (215) 615-6510
Patient appointments: 800-789-7366 (PENN)

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