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David M. Raizen, MD, PhD, DABSM

David M. Raizen, MD, PhD, DABSM Physician

Associate Professor of Neurology in Medicine Associate Professor of Neurology in Genetics Associate Professor of Neurology

Languages spoken:

  • Hebrew

Dr. Raizen is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Neurology, 2003
  • Sleep Medicine, 2013

Clinical Expertise:

  • Actigraphy
  • Bilevel Positive Airway Pressure
  • Bruxism
  • Cataplexy
  • Central Sleep Apnea
  • Circadian Rhythm Sleep-Wake Disorders
  • Cognitive Behavioral Therapy
  • Confusional Arousals
  • Continuous Positive Airway Pressure (CPAP)
  • Daytime Sleepiness
  • Enuresis
  • Home Sleep Study
  • Hypersomnia
  • Hypoglossal Nerve Stimulator
  • Inspire Therapy
  • Kline-Levin Syndrome
  • Maintenance of Wakefulness Test
  • Maxillomandibular Advancement
  • Mouth Guard
  • Multiple Sleep Latency Testing
  • Narcolepsy
  • Nightmares
  • Non-Invasive Ventilation
  • Obesity Hypoventilation Syndrome
  • Obstructive Sleep Apnea
  • Parasomnias
  • Periodic Limb Movement Disorder
  • Periodic Paralysis
  • Polysomnography
  • Restless Leg Syndrome (RLS)
  • Shift Work Sleep Disorder
  • Sleep Abnormalities
  • Sleep Apnea
  • Sleep Apnea Study
  • Sleep Apnea-Related Seizure Disorders
  • Sleep Deprivation
  • Sleep Disorders
  • Sleep Endoscopy
  • Sleep Paralysis
  • Sleep Phase Disorder
  • Sleep Related Hallucinations
  • Sleep Related Hypoxemia
  • Sleep Talking
  • Sleep-Related Eating Disorder
  • Sleep-Related Hypoventilation
  • Sleepwalking
  • Snoring
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Texas Southwestern Medical Center
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Academy of Neurology, National Genetics Society of America, National Sleep Research Society, National Society for Neuroscience, International

Hospital Affiliation

Dr. Raizen is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests
The regulation and function of sleep

Key Words: sleep, ecdysis, molting, behavior, amyloid, neuropeptides

Description of Research
Quiescent behavioral states are universal to the animal world with the most famous and mysterious of these being sleep. Despite the fact that we spend one third of our life sleeping, and despite the fact that all animals sleep, the core function of sleep remains a mystery. In addition, the molecular basis underlying sleep/wake regulation is poorly understood.

We use the nematode C. elegans as a model system to address these questions. C. elegans offers many experimental advantages including powerful genetic tools as well as a simple neuroanatomy.

Growth of C. elegans from an embryo to an adult is punctuated by four molts, during which the animal secretes a new cuticle and sheds its old one. Prior to each molt the worm has a quiescent behavioral state called lethargus. Lethargus has several similarities to sleep including rapid reversibility to strong stimulation, increased sensory arousal threshold, and homeostatic regulation. Remarkably, genetic regulation of lethargus quiescence is similar to genetic regulation of sleep in other animals. In particular, lethargus is regulated by a gene that is very similar to a gene regulating circadian sleep in other animals.

In addition to developmentally-timed sleep sleep, C. elegans also sleeps during the adult stage, after exposure to an environment that induces cellular stress. This stress-induced sleep requires just a single neuron, called the ALA neuron, which secretes neuropeptides including those encoded by the gene flp-13.

We have identified additional new sleep regulators in C. elegans and are currently studying how and in which cells these regulators function.

By studying the purpose and regulation of nematode sleep, we will identify additional novel sleep regulators, and gain insight into why sleep had evolved, a central biological mystery.

Rotation projects
Please see David about possible projects.

Selected Publications:

Raizen David M, Zimmerman John E, Maycock Matthew H, Ta Uyen D, You Young-jai, Sundaram Meera V, Pack Allan I: Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451 (7178): 569-72,2008.

Nelson Mathew D, Trojanowski Nicholas F, George-Raizen Julia B, Smith Colin J, Yu C-C, Fang-Yen Christopher, Raizen David M: The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans. Nature communications 4 : 2846,2013.

Nelson Matthew D, Lee Kun He, Churgin Matthew A, Hill Andrew J, Van Buskirk Cheryl, Fang-Yen Christopher, Raizen David M: FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans. Current biology 24 (20): 2406-10,2014.

Trojanowski Nicholas F, Nelson Matthew D, Flavell Steven W, Fang-Yen Christopher, Raizen David M: Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States. The Journal of neuroscience 35 (43): 14571-84,2015.

Yuan Jinzhou, Raizen David M, Bau Haim H: Propensity of undulatory swimmers, such as worms, to go against the flow. Proc Natl Acad Sci U S A. 112 (12): 3606-11,2015.

George-Raizen Julia B, Shockley Keith R, Trojanowski Nicholas F, Lamb Annesia L, and Raizen David M: Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans. Biology Open 3 (11): 1139-1149,2014.

View all publications

Academic Contact Info

Dept Neurology
347B CRB Building
415 Curie Blvd

Philadelphia, PA 19104-4283
Patient appointments: 800-789-7366 (PENN)

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