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David M. Raizen, MD, PhD, DABSM

David M. Raizen, MD, PhD, DABSM Physician

Associate Professor of Neurology
Associate Professor of Neurology in Genetics
Associate Professor of Neurology in Medicine

Languages spoken:

  • Hebrew

Dr. Raizen is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Sleep Medicine

Programs & Centers:

Board Certification:

  • Neurology, 2003
  • Sleep Medicine (ABSM), 2005

Clinical Expertise:

  • Circadian Rhythm Disorders
  • Delayed Sleep Phase Syndrome (DSPD)
  • Geriatric Sleep Disorders
  • Idiopathic Hypersomnolence
  • Insomnia
  • Narcolepsy
  • Restless Leg Syndrome
  • Sleep Apnea
  • Sleep Disorders with Comorbid Neurological Disorders
  • Sleep Study
  • Sleepiness
  • Sleep-related Epilepsy
  • Sleep-related Headache
  • Sleep-related Movement Disorders

Description of Clinical Expertise

Sleep disorders: In particular disorders of sleep regulation and restless leg syndrome.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Texas - Southwest
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurology, National Genetics Society of America, National Sleep Research Society, National Society for Neuroscience, International

Hospital Affiliation

Dr. Raizen is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests
The regulation and function of sleep

Key Words: sleep, ecdysis, molting, behavior, amyloid, neuropeptides

Description of Research
Quiescent behavioral states are universal to the animal world with the most famous and mysterious of these being sleep. Despite the fact that we spend one third of our life sleeping, and despite the fact that all animals sleep, the core function of sleep remains a mystery. In addition, the molecular basis underlying sleep/wake regulation is poorly understood.

We use the nematode C. elegans as a model system to address these questions. C. elegans offers many experimental advantages including powerful genetic tools as well as a simple neuroanatomy.

Growth of C. elegans from an embryo to an adult is punctuated by four molts, during which the animal secretes a new cuticle and sheds its old one. Prior to each molt the worm has a quiescent behavioral state called lethargus. Lethargus has several similarities to sleep including rapid reversibility to strong stimulation, increased sensory arousal threshold, and homeostatic regulation. Remarkably, genetic regulation of lethargus quiescence is similar to genetic regulation of sleep in other animals. In particular, lethargus is regulated by a gene that is very similar to a gene regulating circadian sleep in other animals.

In addition to developmentally-timed sleep sleep, C. elegans also sleeps during the adult stage, after exposure to an environment that induces cellular stress. This stress-induced sleep requires just a single neuron, called the ALA neuron, which secretes neuropeptides including those encoded by the gene flp-13.

We have identified additional new sleep regulators in C. elegans and are currently studying how and in which cells these regulators function.

By studying the purpose and regulation of nematode sleep, we will identify additional novel sleep regulators, and gain insight into why sleep had evolved, a central biological mystery.

Rotation projects
Please see David about possible projects.

Selected Publications:

Raizen David M, Zimmerman John E, Maycock Matthew H, Ta Uyen D, You Young-jai, Sundaram Meera V, Pack Allan I: Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451 (7178): 569-72,2008.

Nelson Mathew D, Trojanowski Nicholas F, George-Raizen Julia B, Smith Colin J, Yu C-C, Fang-Yen Christopher, Raizen David M: The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans. Nature communications 4 : 2846,2013.

Nelson Matthew D, Lee Kun He, Churgin Matthew A, Hill Andrew J, Van Buskirk Cheryl, Fang-Yen Christopher, Raizen David M: FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans. Current biology 24 (20): 2406-10,2014.

Trojanowski Nicholas F, Nelson Matthew D, Flavell Steven W, Fang-Yen Christopher, Raizen David M: Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States. The Journal of neuroscience 35 (43): 14571-84,2015.

Yuan Jinzhou, Raizen David M, Bau Haim H: Propensity of undulatory swimmers, such as worms, to go against the flow. Proc Natl Acad Sci U S A. 112 (12): 3606-11,2015.

George-Raizen Julia B, Shockley Keith R, Trojanowski Nicholas F, Lamb Annesia L, and Raizen David M: Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans. Biology Open 3 (11): 1139-1149,2014.

View all publications

Academic Contact Info

Dept Neurology
462 Stemmler Hall
415 Curie Blvd

Philadelphia, PA 19104-4283
Patient appointments: 800-789-PENN (7366)

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