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David Alexander Pegues, MD

David Alexander Pegues, MD Physician

Co-Director, Antimicrobial Management Program, Hospital of the University of Pennsylvania Medical Director, Healthcare Epidemiology and Infection Control, Hospital of the University of Pennsylvania Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Pegues is employed by Penn Medicine.

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  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
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Clinical Specialties


  • Infectious Diseases

Programs & Centers:

Board Certification:

  • Infectious Disease, 1996
  • Internal Medicine, 1989

Clinical Expertise:

  • AIDS
  • Anal Pap Smear
  • Antiretroviral Salvage Therapy
  • Aspergillosis
  • Bone Infection (Osteomyelitis)
  • C. Difficile (Clostridium Difficile Diarrhea)
  • Cellulitis
  • Encephalitis
  • Fever of Unknown Origin
  • Flu (Influenza)
  • Flu Shot Vaccination
  • Fungal Meningitis
  • Fungemia
  • Genital Warts (Condyloma Acuminatum)
  • Gonorrhea
  • Hepatitis
  • Hepatitis A Vaccination
  • Hepatitis B
  • Hepatitis B Vaccination
  • Hepatitis C
  • Herpes Simplex Virus (HSV)
  • Histoplasmosis
  • HIV and AIDS
  • HPV Vaccination
  • Human Papilloma Virus
  • Japanese Encephalitis Vaccination
  • Joint Infection
  • Lyme Disease
  • Lymphogranuloma Venereum
  • Malaria
  • Measles Vaccination
  • Meningitis
  • Meningitis Vaccination
  • Menningococcal Vaccine
  • MMR Vaccine
  • Mycobacterium
  • Mycobacterium Avium Complex
  • Mycoplasma
  • Mycosis
  • Parasitic Diseases
  • Pneumonia
  • Pneumonia Vaccination
  • Polio Vaccination
  • Pre-Exposure Prophylaxis
  • Prosthetic Joint Infection
  • Pyelonephritis
  • Rabies Vaccination
  • Sexually Transmitted Diseases (STD)
  • Shingles
  • Shingles Vaccination
  • Staph Infection
  • Swollen Lymph Nodes
  • Syphilis
  • Transplant Related Infection
  • Travel Medicine
  • Travel Vaccination
  • Travelers' Diarrhea
  • Tropical Medicine
  • Tuberculosis (TB)
  • Tuberculosis Testing
  • Typhoid Fever Vaccination
  • Viral Encephalitis
  • Viral Meningitis
  • Wound Infection
  • Yellow Fever Vaccination
Show All Expertise

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Chicago
Residency: Temple University Hospital
Residency: Centers for Disease Control and Prevention
Residency: Massachusetts General Hospital


AHRQ, National American Society of Microbiology (ASM), National DaVita/Total Renal Care, Denver, CO, National Infectious Disease Society of American (IDSA), National SERES Pharmaceuticals, National Society of Health Care Epidemiologist of American (SHEA), National

Hospital Affiliation

Dr. Pegues is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Pegues’ current research interests include evaluating clinical decision support tools to improve the use of medical devices, microbiology testing and antimicrobial therapy for infection diagnosis and management; evaluating novel technologies and implementation strategies to reduce environmental microbial contamination and infection risk; and the epidemiology and prevention of infections in solid organ transplant recipients.

Selected Publications:

Zeigler M, Landsburg D, Pegues D, Bilker W, Gilmar C, Kucharczuk C, Gorman T, Bink K, Moore, A, Stadtmauer E, Fitzpatrick R, Mangan P, Kraus K, Han J: Fluoroquinolone prophylaxis is highly effective for the prevention of central line-associated bloodstream infections in autologous stem cell transplant patients Biol Blood Marrow Transplant 25 : 1004-10,2019.

Ziegler M, Han JH, Landsburg D, Pegues D, Reesey E, Gilmar C, Gorman T, Bink K, Moore A, Kelly BJ: Impact of levofloxacin for the prophylaxis of bloodstream infection on the gut microbiome in patients with hematologic malignancy Open Forum Infect Dis 6 : ofz252,2019.

Zeigler M, Freyer C, Landsburg D, Pegues D, Hirsch R, Kucharczuk C, Gilmar C, Gorman T, Palmer M, Harker C, Lightheart E, Han J: Reducing C. difficile risk: guiding appropriate acid suppression in Hematology-Oncology SHEA Spring 2019 Conference, Boston, MA : 2019.

Muñoz-Price LS, Bowdle A, Johnston BL, Bearman GM, Camins B, Dellinger EP, Geisz-Everson MA, Holzmann-Pazgal G, Murthy R, Pegues D, Prielipp R, Rubin ZA, Schaffzin J Yokoe D, Birnbach D.: SHEA Expert Guidance: Infection Prevention in the Operating Room Anesthesia Work Area Infect Control Hosp Epidemiol 11 : 1-17,2018.

Scheiber M, Pegues D, van Hout B, Rodriquez J, Cassin M, Huwe A, Njord L, Aronoff G: Analysis of after-hours oral antibiotic protocol for the treatment of suspected peritonitis in peritoneal dialysis patients. ASN Kidney Week 2018, San Diego, CA : 2018.

Ziegler M, Kelly B, Landsburg D, Pegues D, Reesey E, Gilmar C, Gorman T, Bink K, Moore A, Han J: Impact of levofloxacin for the prophylaxis of bloodstream infection on the gut microbiome in patients with hematologic malignancy ID Week 2018 Annual Meeting, San Francisco, CA : 2018.

Lautenbach E, Pegues D, Fuchs B, Martin N, Nachamkin IN, Bilker W, Tolomeo P, Cressman L, Omorogbe K, Han JH: Randomized Controlled Trial of the Effect of Copper Textiles on Healthcare-Associated Infections and Multidrug-Resistant Organisms: The “Investigating Microbial Pathogen Activity of Copper Textiles” (IMPACT) Study ID Week 2018 Annual Meeting, San Francisco, CA : 2018.

Weingart MF, Vecker R, Fitzpatrick R, Lautenbach E, Pegues DA, Kelly BJ: Electronic records of daily subglottic suctioning predict infectious and non-infectious adverse ventilator-associated events during critical care ID Week 2018 Annual Meeting, San Francisco, CA : 2018.

Wigneswaran J, Van Wyck D, Pegues D, Gholam P, Nissenson AR: Hepatitis C virus infection in patients with end stage renal disease Hemodial Int 22 : 297-307,2018.

Ziegler M, Landsburg D, Pegues D, Alby K, Gilmar C, Bink K, Gorman T, Moor A, Han J: Clinical characteristics and outcomes of hematologic malignancy patients with Clostridium difficile toxin EIA versus PCR positive test results Infect Control Hosp Epidemiol 38 : 863-866,2018.

Academic Contact Info

Ground Founders, Hospital of the University of Pennsylvania

Philadelphia, PA 19104-4283
Phone: (215) 614-1614